Penetration of VP 16-213 into cerebrospinal fluid after high-dose intravenous administration.
1984 ◽
Vol 2
(3)
◽
pp. 215-220
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Keyword(s):
VP 16-213 in standard doses is active against a number of solid tumors. Its penetration into the cerebrospinal fluid (CSF) is very limited at these dose levels. In 10 patients treated with high-dose VP 16-213 (0.9-2.5 g/m2), CSF levels of up to 0.54 microgram/mL were detected. In two patients with central nervous system (CNS) metastases of small cell lung cancer (SCLC) a response was seen after 1.0 and 1.5 g/m2 intravenously. High-dose VP 16-213 can possibly play a role in the treatment of CNS metastases of SCLC. Its application in late intensification regimens as a form of prophylaxis of CNS metastases should be investigated.
Keyword(s):
2016 ◽
Vol 5
(6)
◽
pp. 588-598
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Keyword(s):
2018 ◽
Vol 36
(15_suppl)
◽
pp. e14019-e14019
Keyword(s):
Keyword(s):
2019 ◽
Vol 144
(1)
◽
pp. 235-237
◽
Keyword(s):
2019 ◽
Keyword(s):
2010 ◽
Vol 5
(7)
◽
pp. 950-955
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