Bowel perforation and fistula formation in colorectal cancer patients treated on Eastern Cooperative Oncology Group (ECOG) studies E2200 and E3200

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 3017-3017 ◽  
Author(s):  
B. J. Giantonio ◽  
H. X. Chen ◽  
P. J. Catalano ◽  
N. J. Meropol ◽  
P. J. O'Dwyer ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Bowel Perforation ◽  
Eastern Cooperative Oncology Group ◽  
Fistula Formation ◽  
Oncology Group ◽  
Colorectal Cancer Patients

scholarly journals Relationship between adverse events of adjuvant chemotherapy and survival outcomes: mediation analysis of Chinese colorectal cancer patients

2020 ◽  
Author(s):  
Chang Geng ◽  
Yuanren Tong ◽  
Na Zhou ◽  
Yingyi Wang
Keyword(s):  
Colorectal Cancer ◽  
Adjuvant Chemotherapy ◽  
Adverse Events ◽  
Cancer Patients ◽  
Eastern Cooperative Oncology Group ◽  
Advanced Age ◽  
Survival Outcomes ◽  
Oncology Group ◽  
Mediation Effects ◽  
Colorectal Cancer Patients

Abstract Purpose：We focus on adverse events in colorectal cancer patients with advanced age, high Eastern Cooperative Oncology Group scores and comorbidities. Methods：408 Chinese colorectal cancer patients undergoing adjuvant chemotherapy at Peking Union Medical College Hospital were included. The cumulative incidences of different adverse events and mediation analyses were analyzed with respect to age, Eastern Cooperative Oncology Group status and comorbidities. Results：Young patients and patients with Eastern Cooperative Oncology Group score 1 had a significantly higher incidence of digestive adverse events related to adjuvant therapy. There were no significant mediation effects of adverse events on survival. Conclusion：Advanced age did not directly lead to poor survival outcomes and adverse events. Although higher Eastern Cooperative Oncology Group scores and comorbidity led to impaired survival and higher incidence of adverse events, the latter had no mediation effects on survival outcomes.

Neutrophil/lymphocyte Ratio after Flow Citometry Periferic Blood Cell Detection - Predictive Marker of Anastomotic Fistula in Colorectal Cancer Surgery

2020 ◽  
Vol 71 (6) ◽  
pp. 295-306
Author(s):  
Dumitru Radulescu ◽  
Vlad Dumitru Baleanu ◽  
Andrei Nicolaescu ◽  
Marius Lazar ◽  
Marius Bica ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Rectal Surgery ◽  
Predictive Marker ◽  
Fistula Formation ◽  
Cell Detection ◽  
Colon And Rectal Surgery ◽  
Optimal Value ◽  
Anastomotic Fistula ◽  
Colorectal Cancer Patients

Anastomotic fistula is a dreadful complication of colon and rectal surgery that can put life into danger, being common after colorectal surgery. The preoperative lymphocyte neutrophil ratio (NLR) is known as a prognostic marker for colorectal cancer patients. The existence of a predictive marker of anastomotic fistula in colorectal cancer patients is not fully undestood, so we proposed to investigate the utility of preoperative NLR as a predictor of anastomotic fistula formation. This study the Neutrophils and lymphocytes were detected from periferic blood using flow citometry. We retrospectively evaluated 161 patients with colorectal cancer, who were treated curatively, in which at least one anastomosis was performed, comparing NLR values between patients who had fistula and those with normal healing, then comparing the group with low NLR, with the group with increased NLR, after finding the optimal value of NLR using the ROC curve.The optimal value of the NLR after establishing the cutoff value was 3.07. Between the low NLR group (n=134) and the high NLR group (n=27), were observed statistically significant differences in fistula (p [0.001) and death (p=0.001). The odds ratio for failure in the group with increased NLR was 10.37, which means that patients with NLR]3.54 have a chance of developing anastomotic fistula greater than 10.37 comparable to patients with lower NLR. We suggest the preoperative use of NLR can be used as a predictive marker of anastomotic fistula than can increase the quality of preoperative preparation and therefore the establishment of the optimal surgical technique that can lead to anastomotic fistula risk decrease.

scholarly journals Gastrointestinal perforation and fistula formation in colorectal cancer patients during regorafenib treatment

2015 ◽  
Vol 26 ◽  
pp. vii100
Author(s):  
Ayako Doi ◽  
Kohei Shitara ◽  
Shota Fukuoka ◽  
Yasutoshi Kuboki ◽  
Hideaki Bando ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Gastrointestinal Perforation ◽  
Fistula Formation ◽  
Colorectal Cancer Patients
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