Tamoxifen's agonist effect on breast cancer growth is mediated by activation of EGFR/HER-2 with preservation of its antagonist effect on ER-dependent gene expression

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 541-541
Author(s):  
S. Massarweh ◽  
C. K. Osborne ◽  
M. Dipietro ◽  
A. E. Wakeling ◽  
R. Schiff
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Growth ◽  
Her 2 ◽  
Breast Cancer Growth ◽  
Antagonist Effect

scholarly journals Periostin Short Fragment with Exon 17 via Aberrant Alternative Splicing Is Required for Breast Cancer Growth and Metastasis

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 892
Author(s):  
Yuka Ikeda-Iwabu ◽  
Yoshiaki Taniyama ◽  
Naruto Katsuragi ◽  
Fumihiro Sanada ◽  
Nobutaka Koibuchi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Cells ◽  
Matrix Protein ◽  
Interaction Analysis ◽  
Terminal Region ◽  
Cancer Growth ◽  
Collagen Gene ◽  
Short Fragment ◽  
Breast Cancer Growth

Background: Periostin (POSTN) is a 93 kDa matrix protein that helps to regulate collagen gene expression in the extracellular matrix. POSTN overexpression is a prognostic factor in malignant cancers; however, some researchers have observed it in the stroma, whereas others have reported it on tumors. Objective: This study aimed to investigate the function of POSTN on tumors. Methods and Results: We found that POSTN in cancer cells can be detected by using an antibody against the POSTN C-terminal region exon 17 (Ex17 antibody), but not with an antibody against the POSTN N-terminal region exon 12 (Ex12 antibody) in patients with breast cancer. In a fraction secreted from fibroblasts, LC–MS/MS analysis revealed a short fragment of POSTN of approximately 40 kDa with exon 17. In addition, molecular interaction analysis showed that POSTN with exon 17, but not POSTN without exon 17, bound specifically to wnt3a, and the Ex17 antibody inhibited the binding. Conclusion: A short fragment of POSTN with exon 17, which originates in the fibroblasts, is transported to cancer cells, whereas POSTN fragments without exon 17 are retained in the stroma. The Ex17 antibody inhibits the binding between POSTN exon 17 and wnt3a.

scholarly journals The SOX11 transcription factor is a critical regulator of basal-like breast cancer growth, invasion, and basal-like gene expression

Oncotarget ◽  
2016 ◽  
Vol 7 (11) ◽  
pp. 13106-13121 ◽  
Author(s):  
Jonathan H. Shepherd ◽  
Ivan P. Uray ◽  
Abhijit Mazumdar ◽  
Anna Tsimelzon ◽  
Michelle Savage ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Transcription Factor ◽  
Cancer Growth ◽  
Basal Like Breast Cancer ◽  
Breast Cancer Growth

Combined Treatment with Exendin-4 and Metformin Attenuates Breast Cancer Growth

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1227-P
Author(s):  
CHIKAYO IWAYA ◽  
TAKASHI NOMIYAMA ◽  
TAKAKO KAWANAMI ◽  
YURIKO HAMAGUCHI ◽  
TOMOKO TANAKA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Combined Treatment ◽  
Cancer Growth ◽  
Breast Cancer Growth

Amyloid Precursor Protein Underwent Proteolytic Cleavage by ADAM10 and Mediated Breast Cancer Growth and Migration

2018 ◽  
Author(s):  
Julia Y. S. Tsang ◽  
Michelle A. Lee ◽  
Tsz-Hei Chan ◽  
Joshua Li ◽  
Yun-Bi Ni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Amyloid Precursor Protein ◽  
Proteolytic Cleavage ◽  
Precursor Protein ◽  
Cancer Growth ◽  
And Migration ◽  
Breast Cancer Growth
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