Outcomes of patients diagnosed with DCIS with isolated tumor cells or micrometastases on sentinel lymph node biopsy.

2011 ◽  
Vol 29 (27_suppl) ◽  
pp. 133-133
Author(s):  
G. Moscol ◽  
M. S. Morginstin
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Tumor Cells ◽  
Lymph Node Biopsy ◽  
Isolated Tumor Cells ◽  
Time To Recurrence ◽  
Node Biopsy ◽  
Pertinent Data

133 Background: Ductal carcinoma in situ of the breast (DCIS) is considered a precancerous condition. Nevertheless, 6 to 13% of cases will present cancerous cells in the sentinel lymph node biopsy (SNB) when analyzed using immunohistochemistry (IHC). Current guidelines do not specify if patients with isolated tumor cells (ITC, staged as N0[i+] for clusters <0.2mm) or with micrometastases (micromets, staged as N1mic for clusters between 0.2mm and 2 mm) would benefit from radiation or systemic therapy. We compared the clinical outcomes of patients diagnosed with DCIS and found to have ITC or micromets on SNB to those of patients diagnosed with DCIS without SNB analysis. Methods: Retrospective study. Medical records from patients diagnosed with DCIS at the Cancer Center of AEMC between 01/01/97 and 12/31/08 were reviewed and the SNB status assessed. Other pertinent data (receptor status, type of recurrence and time to recurrence) was collected. The primary outcomes were recurrence/distant metastasis rate (RR) confirmed by biopsy and the time to recurrence (TTR). Descriptive statistics, chi-square and Mann-Whitney U tests were used to analyze the data. Results: Of the patients diagnosed with DCIS between 1997 and 2008 (N=743), 145 were lost to follow up; 598 charts were analyzed. Only 22% of patients had a SNB. Those that underwent the SNB showed a higher RR as compared to those w/o a SNB (9.2% vs 3.6%, p=0.018). The average TTR between groups showed a wide distribution and no statistically significant difference (SNB mean= 2163 days, S.D=1664; w/o SNB mean= 1300 days, S.D. =819, p=0.180). Subgroup analysis in the SNB group showed that patients w/o IHC exam showed the highest rate of recurrence (6 cases, 13.6%), as compared to those with negative findings (5 cases, 7.6%), those with isolated tumor cells (1 case, 5.9%) and those with micromets (0 cases) (p=0.597). Conclusions: Patients with SNB had a higher RR when compared to those w/o SNB. Among patients with SNB, those w/o IHC had a higher RR as compared to those with SNB and IHC (although p > 0.05), possibly due to unidentified ITC/micromets. These results are limited due to the small number of cases with SNB and short follow up interval for patients with SNB and performed IHC.

Sentinel Lymph Node Biopsy and Isolated Tumor Cells in Invasive Lobular Versus Ductal Breast Cancer

2016 ◽  
Vol 16 (4) ◽  
pp. e75-e82 ◽  
Author(s):  
Wilfred Truin ◽  
Rudi M. Roumen ◽  
Sabine Siesling ◽  
Margriet van der Heiden-van der Loo ◽  
Dorien J. Lobbezoo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Tumor Cells ◽  
Lymph Node Biopsy ◽  
Isolated Tumor Cells ◽  
Node Biopsy ◽  
Ductal Breast Cancer

Long-term follow-up of vulvar cancer patients evaluated with sentinel lymph node biopsy alone

2014 ◽  
Vol 133 (3) ◽  
pp. 416-420 ◽  
Author(s):  
Katina Robison ◽  
Dario Roque ◽  
Carolyn McCourt ◽  
Ashley Stuckey ◽  
Paul A. DiSilvestro ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Cancer Patients ◽  
Vulvar Cancer ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Long Term Follow Up

Polypoid Spitz nevus: two cases evaluated with genetic technique, prolonged follow up, and sentinel lymph node biopsy

2011 ◽  
Vol 38 (9) ◽  
pp. 747-752 ◽  
Author(s):  
Ilaria Pennacchia ◽  
Rita Gasbarra ◽  
Liborio Manente ◽  
Roberto Pisa ◽  
Simone Garcovich ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Lymph Node Biopsy ◽  
Spitz Nevus ◽  
Node Biopsy ◽  
Genetic Technique

scholarly journals Sentinel Lymph Node Biopsy Pathology and 2-Year Postsurgical Recurrence of Breast Cancer in Kenyan Women

2018 ◽  
pp. 1-7
Author(s):  
Nathan R. Brand ◽  
Ronald Wasike ◽  
Khalid Makhdomi ◽  
Rajendra Chauhan ◽  
Zahir Moloo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Lymph Node Biopsy ◽  
Stage I ◽  
Stage Ii ◽  
Node Biopsy

Purpose The goal of this study was to describe the pathologic findings and early follow-up experience of patients who underwent a sentinel lymph node biopsy (SLNB) at Aga Khan University Hospital (AKUH) between 2008 and 2017. Patients and Methods We performed a retrospective analysis of women with breast cancer who underwent an SLNB at AKUH between 2008 and 2017. The SLNB was performed on patients with stage I and stage II breast cancer, and identification of the sentinel lymph node was made by radioactive tracer, blue dye, or both, per availability and surgeon preference. Demographic, surgical, and pathologic data, including immunohistochemistry of the surgical sample for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, were abstracted from the patient records. Follow-up data were available for a subset of patients. Results Between 2008 and 2017, six surgeons performed SLNBs on 138 women, 129 of whom had complete records and were included in the study. Thirty-one of 129 (24%) had a positive SLNB, including 10 of 73 (14%) with stage I and 21 of 56 (38%) with stage II disease. Seventy-eight patients (60%) received systemic adjuvant chemotherapy and 79 (62%) received radiation therapy, and of the 102 patients who were estrogen receptor positive, 86 (85%) received endocrine therapy. Seventy-nine patients were observed for > 2 years, and, of these, four (5.1%) had a regional recurrence. Conclusion The SLNB positivity rates were similar to those of high-income country (HIC) cohorts. However, preliminary data suggest that recurrence rates are elevated at AKUH as compared with those of HIC cohorts, perhaps because of a lower use of radiotherapy and chemotherapy at AKUH compared with HIC cohorts or because of differences in the characteristics of the primary tumor in patients at AKUH as compared with those in HICs.

Sentinel Lymph Node Biopsy versus Nodal Observation in Melanoma

2017 ◽  
Author(s):  
Rachel J. Kwon
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Clinical Case ◽  
Surgical Oncology ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Study Intervention ◽  
Landmark Study

This chapter provides a summary of a landmark study in surgical oncology. In patients with melanoma who undergo wide excision, does sentinel lymph node biopsy improve survival versus nodal observation (a “wait-and-watch” approach)? Starting with that question, it describes the basics of the study, including funding, year study began, year study was published, study location, who was studied, who was excluded, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case on sentinel lymph node biopsy versus nodal observation in melanoma.

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