Compromised Health-Related Quality of Life in Patients With Low-Grade Glioma

2011 ◽  
Vol 29 (33) ◽  
pp. 4430-4435 ◽  
Author(s):  
Neil K. Aaronson ◽  
Martin J.B. Taphoorn ◽  
Jan J. Heimans ◽  
Tjeerd J. Postma ◽  
Chad M. Gundy ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Healthy Controls ◽  
Health Related Quality ◽  
Neurocognitive Deficits ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related

Purpose To investigate the generic and condition-specific health-related quality of life (HRQL) of patients with low-grade glioma (LGG). Patients and Methods A total of 195 patients with LGG, which was diagnosed, on average, 5.6 years before the study, were compared with 100 patients with hematologic (non-Hodgkin's) lymphoma and chronic lymphatic leukemia cancer (NHL/CLL) and 205 general population controls who were comparable with patients with LGG at the group level for age, sex, and education (healthy controls). Generic HRQL was assessed with the Short Form-36 (SF-36) Health Survey, and condition-specific HRQL was assessed with the Medical Outcomes Study cognitive function questionnaire and the European Organisation for Research and Treatment of Cancer brain cancer module. Objective neurocognitive functioning was assessed with a standardized battery of neuropsychological tests. Results No statistically significant differences were observed between patients with LGG and patients with NHL/CLL in SF-36 scores. Patients with LGG scored significantly lower than healthy controls on six of eight scales and on the mental health component score of the SF-36. Approximately one quarter of patients with LGG reported serious neurocognitive symptoms. Female sex, epilepsy burden, and number of objectively assessed neurocognitive deficits were associated significantly with both generic and condition-specific HRQL. Clinical variables, including the time since diagnosis, tumor lateralization, extent of surgery, and radiotherapy, did not show a consistent relationship with HRQL. Conclusion Patients with LGG experienced significant problems across a broad range of HRQL domains, many of which were not condition-specific. However, the neurocognitive deficits and epilepsy that were relatively prevalent among patients with LGG were associated with negative HRQL outcomes and, thus, contributed additionally to the vulnerability of this population of patients with cancer.

scholarly journals Impact of neurocognitive deficits on patient–proxy agreement regarding health-related quality of life in low-grade glioma patients

2016 ◽  
Vol 26 (4) ◽  
pp. 869-880 ◽  
Author(s):  
Divine E. Ediebah ◽  
◽  
Jaap C. Reijneveld ◽  
Martin J. B. Taphoorn ◽  
Corneel Coens ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Health Related Quality ◽  
Neurocognitive Deficits ◽  
Related Quality ◽  
Health Related

scholarly journals Reporting of patient-reported health-related quality of life in adults with diffuse low-grade glioma: a systematic review

2016 ◽  
pp. now107 ◽  
Author(s):  
Daniel M. Fountain ◽  
Dominic Allen ◽  
Alexis J. Joannides ◽  
Dipankar Nandi ◽  
Thomas Santarius ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Health Related Quality ◽  
Patient Reported ◽  
Related Quality ◽  
Health Related ◽  
Reported Health

scholarly journals P230 Health-related quality of life in adolescents and young adults (AYA) with inflammatory bowel disease and its correlations with demographic, clinical, laboratory and therapeutic evaluations

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S257-S258
Author(s):  
J Oba ◽  
M Deboni ◽  
R Toma ◽  
C Sobrado ◽  
M Azevedo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ulcerative Colitis ◽  
Young Adults ◽  
Healthy Controls ◽  
Health Related Quality ◽  
Overlap Syndromes ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related

Abstract Background IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), are chronic recurrent inflammatory diseases of the gastrointestinal tract, most often diagnosed in adolescence and young adulthood. Extra-intestinal manifestation (EIM) may be present initially in up 50% or before IBD is diagnosed. IBD and its complications are associated with morbidity and has considerable impact upon patients’ health-related quality of life (HRQoL). HRQoL is an essential complement to the examination of clinical symptoms and functional limitations and has emerged as an important outcome measure to evaluate an individual’s adaptation to a chronic medical condition like IBD. It is known the neurocognitive maturation that support integration of executive and emotion systems are not fully mature until 25 years, making this period a time of socio-emotional vulnerability and adjustment. So, our objective was to evaluate the HRQoL in adolescents and young adults (AYA) patients with IBD and compare with a peer’s health control and investigate the variables which can be attributed to HRQoL in these patients. Methods 59 AYA IBD patients (13–25 years) and 60 AYA healthy controls (13–25 years) completed the Pediatric Quality of Life Inventory 4.0 (PedsQL4.0), Short Form Health Survey (SF-36) questionnaires and pain visual scale, according to age. After we compared HRQoL between Crohn’s disease (CD) vs. UC (ulcerative colitis) in AYA population. The demographic data, extra-intestinal manifestation, overlap syndromes, disease active status, treatment and outcomes were also evaluated. Results PedsQL4.0 domain ‘school/ work’ and SF-36 domain ‘general health perception’ was reduced in IBD AYA patients compared with healthy controls (p < 0.05). However, no difference in all domains and pain scale was observed between CD and UC AYA patients. Disease activity, as well as extra-intestinal manifestations, overlap syndromes, treatments and outcomes, did not influence the HRQoL of the AYA patients. Autoimmune sclerosing cholangitis and the use of prednisone were significantly higher among UC patients, whereas previous gut surgery was higher between CD patients. However, these disease factors did not significantly influence the HRQoL between CD vs. UC. Conclusion HRQoL was significantly lower among IBD AYA patients when compared with healthy controls. Disease factors did not influence HRQoL between CD and UC AYA patients. These results highlight areas to focus clinical attention for assessment and future interventions among AYA with IBD.

scholarly journals The association between cognitive functioning and health-related quality of life in low-grade glioma patients

2014 ◽  
Vol 1 (2) ◽  
pp. 40-46 ◽  
Author(s):  
Florien W. Boele ◽  
Maaike Zant ◽  
Emma C.E. Heine ◽  
Neil K. Aaronson ◽  
Martin J.B. Taphoorn ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cognitive Functioning ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Health Related Quality ◽  
Cognitive Domains ◽  
Related Quality ◽  
Health Related ◽  
Disease Specific

Abstract Background Glioma patients are not only confronted with the diagnosis and treatment of a brain tumor, but also with changes in cognitive and neurological functioning that can profoundly affect their daily lives. At present, little is known about the relationship between cognitive functioning and health-related quality of life (HRQOL) during the disease trajectory. We studied this association in low-grade glioma (LGG) patients with stable disease at an average of 6 years after diagnosis. Methods Patients and healthy controls underwent neuropsychological testing and completed self-report measures of generic (MOS SF36) and disease-specific (EORTC BN20) HRQOL. Associations were determined with Pearson correlations, and corrections for multiple testing were made. Results We analyzed data gathered from 190 LGG patients. Performance in all cognitive domains was positively associated with physical health (SF36 Physical Component Summary). Executive functioning, processing speed, working memory, and information processing were positively associated with mental health (SF36 Mental Component Summary). We found negative associations between a wide range of cognitive domains and disease-specific HRQOL scales. Conclusions In stable LGG patients, poorer cognitive functioning is related to lower generic and disease-specific HRQOL. This confirms that cognitive assessment of LGG patients should not be done in isolation from assessment of its impact on HRQOL, both in clinical and in research settings.

Prospective assessment of health-related quality of life in patients with low-grade glioma

2011 ◽  
Vol 20 (8) ◽  
pp. 1859-1868 ◽  
Author(s):  
Cagdas Yavas ◽  
Faruk Zorlu ◽  
Gokhan Ozyigit ◽  
Murat Gurkaynak ◽  
Guler Yavas ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Health Related Quality ◽  
Related Quality ◽  
Prospective Assessment ◽  
Health Related

scholarly journals P15.02 * HEALTH-RELATED QUALITY OF LIFE IN STABLE, LONG-TERM LOW-GRADE GLIOMA SURVIVORS

2014 ◽  
Vol 16 (suppl 2) ◽  
pp. ii73-ii74
Author(s):  
F. W. Boele ◽  
L. Douw ◽  
J. C. Reijneveld ◽  
R. Robben ◽  
M. J. B. Taphoorn ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related
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