Hodgkin’s disease and HIV infection (HD-HIV): Prognostic factors in 596 patients (pts) within the group of European Cooperation on AIDS and Tumors (GECAT).

8058 Background: Hodgkin’s disease (HD) is the most common non-AIDS defining tumour diagnosed in HIV setting. The introduction of highly active antiretroviral therapy (HAART) has opened a new prospective in the treatment of pts with HD-HIV as the better control of the underlying HIV infection allows the use of more aggressive chemotherapy regimens, including high dose chemotherapy. However, up to now prognostic factors on overall survival (OS) or time to treatment failure (TTF) have not yet been identified. Methods: In order to identify prognostic factors, we analyzed data on 596 pts with HD-HIV diagnosed and treated in 90 different Institution of 6 European countries from October 1983 to March 2010. All factors were analyzed for OS and TTF. Results: 86% of pts were male and the median CD4 cell count was 224/dl (range 3-1274); 52% of pts had mixed cellularity subtype, stages III-IV were diagnosed in 72% of cases and 55% of pts had extranodal involvement (bone marrow 35%, spleen 21%, liver 14%). The table summarizes the results of multivariate analysis. Conclusions: We identified a new “European Score” for HD-HIV able to predict different outcomes in these patients. This score should be considered for future prospective studies. [Table: see text]

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Hodgkin's Disease and HIV Infection (HD-HIV): Prognostic Factors In 596 Patients (pts) within the European Group for the Study of HIV and Tumours (GECAT)

Blood ◽

10.1182/blood.v116.21.3883.3883 ◽

2010 ◽

Vol 116 (21) ◽

pp. 3883-3883 ◽

Cited By ~ 3

Author(s):

Michele Spina ◽

Josep-Maria Ribera ◽

Jean Gabarre ◽

Christoph Wyen ◽

Silvia Montoto ◽

...

Keyword(s):

Prognostic Factors ◽

Hiv Infection ◽

Cell Count ◽

Highly Active Antiretroviral Therapy ◽

Hodgkin's Disease ◽

Conflicts Of Interest ◽

Hodgkin’S Disease ◽

High Dose ◽

Cd4 Cell Count ◽

Cd4 Cell

Abstract Abstract 3883 Background: Hodgkin's disease (HD) is the most common non-AIDS defining tumour diagnosed in HIV setting. The introduction of highly active antiretroviral therapy (HAART) has opened a new prospective in the treatment of pts with HD-HIV as the better control of the underlying HIV infection allows the use of more aggressive chemotherapy regimens, including high dose chemotherapy. However, up to now prognostic factors on overall survival (OS) or time to treatment failure (TTF) have not been identified yet. Methods: in order to identify prognostic factors, we analyze data on 596 pts with HD-HIV diagnosed and treated in 90 different Institution from 6 European countries from October 1983 to March 2010. All factors were analyzed for OS and TTF. Results: 86% of pts were male and the median CD4 cell count was 224/mL (range 3–1274); 52% of pts had mixed cellularity subtype, stages III-IV were diagnosed in 72% of cases and 55% of pts had extranodal involvement (bone marrow 35%, spleen 21%, liver 14%). Table 1 summarizes the results of multivariate analysis. Conclusion: We identified a new “European Score” (IPS>2 and CD4 cell count <200/mL) for HD-HIV able to predict different outcomes in these patients. This score should be considered for future prospective studies. Disclosures: No relevant conflicts of interest to declare.

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Hodgkin's Disease in Patients with HIV Infection

Advances in Hematology ◽

10.1155/2011/402682 ◽

2011 ◽

Vol 2011 ◽

pp. 1-7 ◽

Cited By ~ 10

Author(s):

Michele Spina ◽

Antonino Carbone ◽

Annunziata Gloghini ◽

Diego Serraino ◽

Massimiliano Berretta ◽

...

Keyword(s):

Hiv Infection ◽

Highly Active Antiretroviral Therapy ◽

High Dose Chemotherapy ◽

New Drugs ◽

Diagnostic Tools ◽

High Dose ◽

Stem Cell Rescue ◽

Highly Active ◽

Phase Ii Studies ◽

Advanced Stages

Hodgkin lymphoma (HL) represents one of the most common non-AIDS-defining cancers with an increasing incidence overtime. Clinically, patients present advanced stages of disease with extranodal involvement in the majority of cases. In the last years, significant improvements in the treatment of patients with HL and HIV infection have been achieved. In the lack of randomized trials, several phase II studies have showed that in the era of highly active antiretroviral therapy (HAART) the same regimens employed in HIV-negative patients with HL can be used in HIV setting with similar results. Moreover, in the last years the feasibility of high dose chemotherapy and peripheral stem cell rescue has allowed to save those patients who failed the upfront treatment. Finally, in the near future, a better integration of diagnostic tools (including PET scan), chemotherapy (including new drugs), radiotherapy, HAART, and supportive care will significantly improve the outcome of these patients.

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Stanford V regimen and concomitant highly active antiretroviral therapy is feasible and active in patients with Hodgkin's disease and HIV infection

AIDS ◽

10.1097/00002030-200007070-00023 ◽

2000 ◽

Vol 14 (10) ◽

pp. 1457-1458 ◽

Cited By ~ 7

Author(s):

Michele Spina ◽

Jean Gabarre ◽

Marco Fasan ◽

Emanuela Vaccher ◽

Umberto Tirelli

Keyword(s):

Antiretroviral Therapy ◽

Hiv Infection ◽

Highly Active Antiretroviral Therapy ◽

Hodgkin's Disease ◽

Hodgkin’S Disease ◽

Highly Active

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Nocardia FarcinicaLung Abscess Presenting in the Context of Advanced HIV Infection: Spontaneous Resolution in Response to Highly Active Antiretroviral Therapy Alone

Canadian Journal of Infectious Diseases and Medical Microbiology ◽

10.1155/2009/181750 ◽

2009 ◽

Vol 20 (3) ◽

pp. e103-e106 ◽

Cited By ~ 4

Author(s):

Arienne S King ◽

Jose G Castro ◽

Gordon CK Dow

Keyword(s):

Antiretroviral Therapy ◽

Hiv Infection ◽

Highly Active Antiretroviral Therapy ◽

Opportunistic Pathogen ◽

Cd4 Cell Count ◽

Highly Active ◽

Metastatic Infection ◽

History Of ◽

Cd4 Cell ◽

The Impact

A 43-year-old man, known to be HIV-positive, presented with a six-week history of symptoms including cough, hemoptysis, anterior chest pain, fever and wasting. His CD4 cell count was 46 cells/μL, and his chest x-ray showed a cavitating lesion in the left upper lobe. Sputum culture was positive forNocardia farcinica. His infection resolved following initiation of antiretroviral therapy.Nocardiais an uncommon opportunistic pathogen in patients with HIV infection and is usually associated with advanced CD4 depletion, cavitary pneumonia, metastatic infection and high mortality. The impact of antiretroviral therapy onNocardiainfection in the setting of HIV has not been clearly elucidated. The current report is the first to present a case in which a complete clinical cure ofNocardiapneumonia has been documented, primarily in response to highly active antiretroviral therapy alone.

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