Clinicopathologic feature and outcome of appendiceal goblet cell carcinoid and neuroendocrine tumor.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14170-e14170
Author(s):  
Wungki Park ◽  
Geetha D. Vallabhaneni ◽  
Ludmila Katherine Martin ◽  
Volkan Adsay ◽  
Charles A. Staley ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Goblet Cell ◽  
Stage Iv ◽  
Disease Recurrence ◽  
Stage I ◽  
State University ◽  
Goblet Cell Carcinoid ◽  
Clinicopathologic Feature ◽  
Emory University ◽  
The Ohio State University

e14170 Background: Goblet cell carcinoid (GCC) of the appendix is a rare tumor comprising 5% of primary appendiceal tumors. GCC shares histological features of both neuroendocrine tumor (NET) and adenocarcinoma. Clinically, GCC also has an intermediate behavior between them. The management of GCC is mostly based on small retrospective series. We report the clinicopathological features, treatments, and outcomes of patients with appendiceal GCCs and NETs from a merged database between Emory University and the Ohio State University. Methods: We identified patients with appendiceal GCCs and NETs treated at these institutions over the period of 12 years from 1999 to 2011. Chart reviews for age, gender, date of diagnosis, TNM stage, chemotherapy, intraperitoneal hyperthermic perfusion (IPHP), surgery, and survival were performed. Results: See table. In the GCC patients with stage I, II, and III, 30 received surgery alone and 1 received surgery plus IPHP. 29 out of 31 (94%) patients are alive without disease recurrence. Out of 6 GCC patients with stage IV, 5 received chemotherapy, 1 received chemotherapy plus IPHP, and 2 (33%) are alive. In the NET patients with stage I,II, and III, all 29 were treated with surgery alone. 29 out of 31 patients are alive and there was no disease-related mortality. Out of 2 NET patients with stage IV, one received chemotherapy and both are alive. Conclusions: Our data confirms the excellent prognosis of appendiceal NET regardless of stage. The outcomes of surgery for patients with stage I, II, and III in both GCCs and NETs were excellent. Patients with stage IV GCCs have higher possibility of aggressive clinical courses. Chemotherapy or IPHP should be considered in the management of stage IV GCCs. [Table: see text]

A comparative analysis of locoregional therapy (hyperthermic intraperitoneal chemotherapy [HIPEC]) and systemic chemotherapy (CT) following cytoreductive surgery in patients (pts) with disseminated mucinous appendiceal cancers (MACA).

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14169-e14169
Author(s):  
Tanios S. Bekaii-Saab ◽  
Ludmila Katherine Martin ◽  
Geetha D. Vallabhaneni ◽  
Wungki Park ◽  
Charles A. Staley ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Cytoreductive Surgery ◽  
Stage Iv ◽  
Locoregional Therapy ◽  
State University ◽  
Significant Survival ◽  
Pertinent Data ◽  
Stage Iv Disease ◽  
Added Benefit ◽  
The Ohio State University

e14169 Background: MACA are rare neoplasms with variable prognosis depending on tumor histology. Peritoneal dissemination is frequent and cytoreductive surgery is the mainstay of treatment (tx). HIPEC and CT may provide additional benefit, but their role is not well understood. We evaluated the role of HIPEC and CT in pts with MACA following cytoreduction. Methods: Pertinent data including demographics, tx and clinical outcome were retrospectively obtained from pts treated at The Ohio State University and Emory University. Tumors were histologically classified as disseminated peritoneal adenomucinosis (DPAM) or peritoneal mucinous carcinomatosis (PMCA) and by TNM stage. Clinical outcome was evaluated according to tx, stage, and histology. Results: 124 pts (41M, 83F) with a median age of 58 years (range 21-82) were included. All pts had stage IV disease, 43 had DPAM and 71 had PMCA (10 unavailable). Following debulking surgery, 27% of pts had HIPEC, 21% had CT, 30% had both and 22% had no additional therapy. For stage IV pts, there was a significant benefit for additional tx after surgery (Table). Pts with DPAM had significantly improved mOS versus PMCA. For pts with PMCA but not DPAM a significant survival advantage was seen for any tx (CT, HIPEC, or both) versus no therapy following surgery. Conclusions: For pts with MACA, additional tx may improve survival following cytoreductive surgery. HIPEC appears to improve outcomes, while systemic CT may not provide added benefit. Prognosis for DPAM histology appears to be superior to PMCA. Pts with PMCA may benefit most from additional tx following cytoreduction. These interesting findings are limited by their retrospective nature and prospective validation is needed. [Table: see text]

scholarly journals Health Sciences Libraries Forecasting Information Service Trends for Researchers: Models Applicable to All Academic Libraries

2016 ◽  
Vol 77 (5) ◽  
pp. 595-613 ◽  
Author(s):  
Timothy J. Cain ◽  
Fern M. Cheek ◽  
Jeremy Kupsco ◽  
Lynda J. Hartel ◽  
Anna Getselman
Keyword(s):  
Information Service ◽  
Information Services ◽  
Lessons Learned ◽  
Health Science ◽  
State University ◽  
Library Community ◽  
New Information ◽  
Planning Framework ◽  
Emory University ◽  
The Ohio State University

To better understand the value of current information services and to forecast the evolving information and data management needs of researchers, a study was conducted at two research-intensive universities. The methodology and planning framework applied by health science librarians at Emory University and The Ohio State University focused on identifying the need for new or retooled information services supporting health and biomedical researchers and their increasing use of digital resources. The lessons learned and outcomes described herein are informing the development and implementation of new information service models and can help forecast changing user needs across the broader library community.

Genomic profile of appendiceal goblet cell carcinoid is distinct compared to appendiceal neuroendocrine tumor and conventional adenocarcinoma

2018 ◽  
Vol 77 ◽  
pp. 166-174 ◽  
Author(s):  
Kwun Wah Wen ◽  
James P. Grenert ◽  
Nancy M. Joseph ◽  
Nafis Shafizadeh ◽  
Anne Huang ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Goblet Cell ◽  
Genomic Profile ◽  
Goblet Cell Carcinoid

Five Decades of Research Experience in Speech Anatomy and Physiology

2016 ◽  
Vol 1 (5) ◽  
pp. 4-12
Author(s):  
David P. Kuehn
Keyword(s):  
Ohio State University ◽  
State University ◽  
Research Experience ◽  
University Of Iowa ◽  
University Of Illinois ◽  
Anatomy And Physiology ◽  
The Ohio State University ◽  
Speech Science ◽  
The University ◽  
East Carolina University

This report highlights some of the major developments in the area of speech anatomy and physiology drawing from the author's own research experience during his years at the University of Iowa and the University of Illinois. He has benefited greatly from mentors including Professors James Curtis, Kenneth Moll, and Hughlett Morris at the University of Iowa and Professor Paul Lauterbur at the University of Illinois. Many colleagues have contributed to the author's work, especially Professors Jerald Moon at the University of Iowa, Bradley Sutton at the University of Illinois, Jamie Perry at East Carolina University, and Youkyung Bae at the Ohio State University. The strength of these researchers and their students bodes well for future advances in knowledge in this important area of speech science.

Cardiology Fellowship Education in the Era of High-density Training, Data Tracking, and Quality Measures

2011 ◽  
Vol 9 (2) ◽  
pp. 99
Author(s):  
Alex J Auseon ◽  
Albert J Kolibash ◽  
◽  
Keyword(s):  
Ohio State University ◽  
Training Data ◽  
State University ◽  
Training Requirements ◽  
Healthcare Environment ◽  
Medical Centers ◽  
Work Hour ◽  
The Ohio State University ◽  
Data Tracking

Background:Educating trainees during cardiology fellowship is a process in constant evolution, with program directors regularly adapting to increasing demands and regulations as they strive to prepare graduates for practice in today’s healthcare environment.Methods and Results:In a 10-year follow-up to a previous manuscript regarding fellowship education, we reviewed the literature regarding the most topical issues facing training programs in 2010, describing our approach at The Ohio State University.Conclusion:In the midst of challenges posed by the increasing complexity of training requirements and documentation, work hour restrictions, and the new definitions of quality and safety, we propose methods of curricula revision and collaboration that may serve as an example to other medical centers.

Evaluation of a New Clinical Test of Fusion Status: A Pilot Study

2019 ◽  
pp. 113-118
Keyword(s):  
Pilot Study ◽  
Ohio State University ◽  
Background Suppression ◽  
Clinical Test ◽  
State University ◽  
Chi Square ◽  
Central Fusion ◽  
Eye Examination ◽  
The Ohio State University ◽  
Chi Square Analysis

Background Suppression is associated with binocular vision conditions such as amblyopia and strabismus. Commercial methods of testing fusion often only measure central fusion or suppression at near. The purpose of this pilot study was to assess a new iPad picture fusion test that assesses foveal and central fusion at near. Methods Participants aged 5 years and older presenting for eye examination at The Ohio State University College of Optometry were enrolled. Results from visual acuity, dry and wet refraction/retinoscopy, stereopsis and cover testing were recorded from the patient chart. The iPad picture fusion test, Worth four-dot, Worth type test with foveal letter targets, and Polarized four-dot were performed by one examiner in a randomized order at 40 cm. Testing was repeated with the anaglyphic filters reversed. Crosstabulation and McNemar chi-square analysis were used to compare the results between fusion testing devices. Results Of the fifty participants (mean age = 17.5), twelve reported suppression and one reported diplopia. Testability was excellent for all tests (98% to 100%). There were no significant differences between tests in reported results (P ≥ 0.22 for all comparisons). No difference in reported fusion or suppression status was observed with change in orientation of the anaglyphic filters. Six participants reported foveal suppression alone at near which was not identified with Worth four-dot at near. Conclusion The iPad picture fusion test provided excellent testability and agreement with commonly used tests of fusion and allowed testing of both central and foveal fusion at near. Nearly half (46%) of participants with suppression reported foveal suppression, supporting the importance of testing for foveal suppression.

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