Structure-activity relationships (SAR) and mechanistic analysis of clinical-stage anti-cancer small molecule ONC201 analogues.

Structure Activity ◽

Mechanistic Analysis ◽

Abstract 349: Structure-activity relationships and mechanistic analysis of analogues of the clinical-stage anti-cancer small molecule ONC201

10.1158/1538-7445.am2016-349 ◽

2016 ◽

Author(s):

Jessica Wagner ◽

Gary Olson ◽

Nallaganchu Rao Bhaskara ◽

Richard S. Pottorf ◽

Garnett J. Mathew ◽

...

Keyword(s):

Small Molecule ◽

Clinical Stage ◽

Structure Activity ◽

Mechanistic Analysis ◽

Discovery of small-molecule nonpeptide antagonists of nociceptin/orphanin FQ receptor: The studies of design, synthesis, and structure–activity relationships for (4-arylpiperidine substituted-methyl)-[bicyclic (hetero)cycloalkanobenzene] derivatives

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.02.014 ◽

2016 ◽

Vol 114 ◽

pp. 345-364 ◽

Cited By ~ 4

Author(s):

Shigeo Hayashi ◽

Katsuyo Ohashi ◽

Sachiko Mihara ◽

Eriko Nakata ◽

Chie Emoto ◽

...

Keyword(s):

Small Molecule ◽

Orphanin Fq ◽

Design Synthesis ◽

Synthesis and structure–activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1)

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2007.01.104 ◽

2007 ◽

Vol 17 (8) ◽

pp. 2171-2178 ◽

Cited By ~ 8

Author(s):

Martin W. Rowbottom ◽

Troy D. Vickers ◽

Junko Tamiya ◽

Mingzhu Zhang ◽

Brian Dyck ◽

...

Keyword(s):

Small Molecule ◽

Hormone Receptor ◽

Structure Activity ◽

Melanin Concentrating Hormone

Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.06.049 ◽

2006 ◽

Vol 16 (18) ◽

pp. 4922-4930 ◽

Cited By ~ 10

Author(s):

Sarah Hudson ◽

Mehrak Kiankarimi ◽

Martin W. Rowbottom ◽

Troy D. Vickers ◽

Dongpei Wu ◽

...

Keyword(s):

Small Molecule ◽

Hormone Receptor ◽

Structure Activity ◽

Melanin Concentrating Hormone

A Comprehensive Overview of Structure‐Activity Relationships of Small‐Molecule Splicing Modulators Targeting SF3B1 as Anticancer Agents

ChemMedChem ◽

10.1002/cmdc.202000642 ◽

2020 ◽

Vol 15 (22) ◽

pp. 2098-2120

Author(s):

Datong Zhang ◽

Fancui Meng

Keyword(s):

Small Molecule ◽

Anticancer Agents ◽

Comprehensive Overview ◽

Abstract 3245: Preclinical evaluation of the imipridone family of small molecules, including analogues of clinical-stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212

10.1158/1538-7445.am2017-3245 ◽

2017 ◽

Author(s):

Jessica Wagner ◽

C. Leah Kline ◽

Gary Olson ◽

Bhaskara Nallaganchu ◽

Richard Pottorf ◽

...

Keyword(s):

Small Molecules ◽

Small Molecule ◽

Clinical Stage ◽

Preclinical Evaluation ◽

Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor: Structure–activity relationships of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.02.043 ◽

2009 ◽

Vol 19 (7) ◽

pp. 1986-1990 ◽

Cited By ~ 9

Author(s):

Diane B. Hauze ◽

Murty V. Chengalvala ◽

Joshua E. Cottom ◽

Irene B. Feingold ◽

Lloyd Garrick ◽

...

Keyword(s):

Small Molecule ◽

Gnrh Receptor ◽

Gonadotropin Releasing Hormone ◽

Releasing Hormone ◽

Receptor Structure ◽

Small Molecule Inhibitors of KDR (VEGFR-2) Kinase: An Overview of Structure Activity Relationships

Current Topics in Medicinal Chemistry ◽

10.2174/1568026023393273 ◽

2002 ◽

Vol 2 (9) ◽

pp. 973-1000 ◽

Cited By ~ 63

Author(s):

Stephen Boyer

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Small-molecule glucosylation by sucrose phosphorylase: structure–activity relationships for acceptor substrates revisited

Carbohydrate Research ◽

10.1016/j.carres.2010.03.035 ◽

2010 ◽

Vol 345 (10) ◽

pp. 1492-1496 ◽

Cited By ~ 14

Author(s):

Christiane Luley-Goedl ◽

Bernd Nidetzky

Keyword(s):

Small Molecule ◽

Sucrose Phosphorylase ◽

Structure-activity relationships of four anti-cancer alkylphosphocholine derivativesIn Vitro andIn Vivo

International Journal of Cancer ◽

10.1002/ijc.2910530312 ◽

1993 ◽

Vol 53 (3) ◽

pp. 418-425 ◽

Cited By ~ 15

Author(s):

Stephan B. Sobottka ◽

Martin R. Berger ◽

Hansjörg Eibl

Keyword(s):

Structure Activity ◽