Cognitive rehabilitation for brain tumor survivors: A pilot study.

2016 ◽  
Vol 34 (3_suppl) ◽  
pp. 140-140
Author(s):  
Nadine M. Richard ◽  
Lori J. Bernstein ◽  
Warren P. Mason ◽  
Normand Laperriere ◽  
Caroline Chung ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Pilot Study ◽  
Cognitive Dysfunction ◽  
Cognitive Rehabilitation ◽  
Statistical Significance ◽  
Executive Dysfunction ◽  
Management Training ◽  
Strategy Training ◽  
Individual Treatment ◽  
Behavioral Regulation

140 Background: Brain tumor survivors often face unique challenges from chronic cognitive deficits such as memory problems or executive dysfunction. Cognitive rehabilitation is a relatively new field. With few well-controlled studies in cancer patients, oncology and supportive care teams lack accessible, reliable tools to address cognitive dysfunction. This pilot study evaluated the feasibility and potential efficacy of two behavioral interventions for brain tumor survivors. Methods: We compared two programs, each with 8 individual treatment sessions and daily homework. Goal Management Training (GMT) is a neuroscience-based integration of mindfulness and strategy training. The Brain Health Workshop (BHW) offers supportive psychoeducation about living with a brain tumor. Using a prospective randomized design, 6 brain tumor patients (with chronic cognitive dysfunction, ≥ 3 months post-radiation or surgery) were enrolled in GMT or BHW and completed a battery of measures at baseline and post-training. Composite scores were calculated by domain, with objective tests of attention, processing speed, memory, and executive functioning, and subjective measures of coping, mood, behavioral regulation and cognitive symptoms. Patient feedback was obtained in post-training qualitative interviews. Results: All patients (Table 1) completed all study activities. Analyses of group differences in composite change scores showed greater improvement in executive functions and greater attainment of pre-training functional goals in the GMT group (p's < .05). The BHW group showed a trend toward greater improvement in mood and behavioral regulation that did not reach statistical significance. Patients in both groups reported satisfaction with their program and continued, frequent (daily to every other day) use of their new knowledge following training. Conclusions: This pilot study demonstrated the feasibility of cognitive rehabilitation for brain tumor survivors between 1 and 8 years post-diagnosis. Results suggest unique benefits of each intervention that will be further explored in a larger clinical trial. [Table: see text]

scholarly journals 45 Cognitive rehabilitation in neuro-oncology: Program development and evaluation

2018 ◽  
Vol 45 (S3) ◽  
pp. S9-S9
Author(s):  
NM Richard ◽  
WP Mason ◽  
D Shultz ◽  
N Laperriere ◽  
BA Millar ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Executive Functions ◽  
Cognitive Rehabilitation ◽  
Controlled Trial ◽  
Pilot Trial ◽  
Management Training ◽  
Strategy Training ◽  
Family Quality Of Life ◽  
Tumor Patients

Background: Brain tumors present unique challenges to patient and family quality of life (QOL). Cognitive dysfunction is common and functionally limiting, with no established treatments. These studies evaluate feasibility and preliminary efficacy of behavioral interventions developed for neuro-oncology patients. Study 1: A randomized controlled trial (N=25 primary brain tumor patients) compared an adapted version of Goal Management Training (GMT, a neuroscience-based integration of mindfulness and strategy training) and a newly-designed supportive psychoeducational intervention (Brain Health Program, BHP) to standard of care. Each intervention comprised 8 individual sessions and at-home practice between sessions. GMT patients’ executive functions improved immediately (p=.077, d=1.13), with maintenance at 4-month follow-up (p=.046, d=1.09). Both intervention groups reported improvements in everyday cognitive functioning immediately (p=.049; d’s GMT=0.43, BHP=0.79) and at follow-up (p=.001; d’s GMT=0.22, BHP=1.01). BHP patients also reported improved mood (p’s=.026 & .012, d’s=0.61 & 0.62). Study 2: Following a needs assessment about cognitive concerns and QOL in brain metastases patients (N=109) and caregivers (N=31), we developed a novel, brief (3 sessions + homework) Cognitive Support Program to provide education and strategy-training in key areas of concern: executive functions, memory, and communication. Options include caregiver co-training, and in-person or web-based delivery. Preliminary data from a pilot trial in progress demonstrate objective and subjective improvements. Conclusions: Cognitive rehabilitation may be a feasible and effective option for primary or metastatic brain tumor patients, addressing a need that is largely unmet in standard cancer care. Further development and larger trials appear warranted, with capacity for remote delivery recommended.

Cognitive rehabilitation for executive dysfunction in brain tumor patients: a pilot randomized controlled trial

2019 ◽  
Vol 142 (3) ◽  
pp. 565-575 ◽  
Author(s):  
Nadine M. Richard ◽  
Lori J. Bernstein ◽  
Warren P. Mason ◽  
Normand Laperriere ◽  
Catherine Maurice ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Brain Tumor ◽  
Cognitive Rehabilitation ◽  
Controlled Trial ◽  
Executive Dysfunction ◽  
Tumor Patients ◽  
Randomized Controlled ◽  
Pilot Randomized Controlled Trial

Cognitive rehabilitation training in patients with brain tumor-related epilepsy and cognitive deficits: a pilot study

2015 ◽  
Vol 125 (2) ◽  
pp. 419-426 ◽  
Author(s):  
Marta Maschio ◽  
Loredana Dinapoli ◽  
Alessandra Fabi ◽  
Diana Giannarelli ◽  
Tonino Cantelmi
Keyword(s):  
Brain Tumor ◽  
Pilot Study ◽  
Cognitive Deficits ◽  
Cognitive Rehabilitation ◽  
Rehabilitation Training

scholarly journals eHealth cognitive rehabilitation for brain tumor patients: results of a randomized controlled trial

2021 ◽  
Author(s):  
Sophie D. van der Linden ◽  
Geert-Jan M. Rutten ◽  
Linda Dirven ◽  
Martin J. B. Taphoorn ◽  
Djaina D. Satoer ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Cognitive Rehabilitation ◽  
Patient Reported Outcomes ◽  
Intervention Group ◽  
Cognitive Outcomes ◽  
Strategy Training ◽  
Control Group ◽  
Low Grade ◽  
Tumor Patients ◽  
Patient Reported

Abstract Background Evidence-based cognitive rehabilitation programs for brain tumor patients are not widely available, despite the high need. We aimed to evaluate the effects of a tablet-based cognitive rehabilitation program on cognitive performance, cognitive complaints, fatigue, and psychological distress in primary brain tumor patients following neurosurgery. Also, attrition, adherence and patient satisfaction with the program were evaluated. Methods Adults with presumed low-grade glioma and meningioma were recruited before surgery. Three months thereafter, participants were allocated to the intervention group or waiting-list control group using minimization. The 10-week eHealth app ReMind, based on the effective face-to-face intervention, consisted of psychoeducation, strategy-training and attention retraining. Performance-based cognitive outcomes and patient-reported outcomes were assessed before surgery and 3, 6 and 12 months thereafter. Mean scores, percentages of cognitively impaired individuals and reliable change indices (RCIs) were compared between groups. Results Sixty-two out of 183 eligible patients were randomized. Of the people who declined, 56% reported that participation would to be too burdensome. All participants found a tablet-app suitable for delivery of cognitive rehabilitation and 90% rated the program as “good” or “excellent”. Performance-based cognitive outcomes and patient-reported outcomes did not significantly differ in group means over time nor RCIs between the intervention (final n = 20) and control group (final n = 25). Conclusions Recruitment at this early stage was difficult, resulting in limited statistical power. No significant effects were demonstrated, while adherence and satisfaction with the eHealth program were good. In clinical practice, ReMind may be helpful, if timing would be adapted to patients’ needs.

scholarly journals Gamma entrainment frequency affects mood, memory and cognition: an exploratory pilot study

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Ryan L. S. Sharpe ◽  
Mufti Mahmud ◽  
M. Shamim Kaiser ◽  
Jianhui Chen
Keyword(s):  
Pilot Study ◽  
Correlation Analysis ◽  
Negative Correlation ◽  
Cognitive Abilities ◽  
Statistical Significance ◽  
Assessment Scores ◽  
Frequency Group ◽  
Before And After ◽  
Mood Score ◽  
40 Hz

AbstractHere we provide evidence with an exploratory pilot study that through the use of a Gamma 40 Hz entrainment frequency, mood, memory and cognition can be improved with respect to a 9-participant cohort. Participants constituted towards three binaural entrainment frequency groups: the 40 Hz, 25 Hz and 100 Hz. Participants attended a total of eight entrainment frequency sessions twice over the duration of a 4-week period. Additionally, participants were assessed based on their cognitive abilities, mood as well as memory, where the cognitive and memory assessments occurred before and after a 5-min binaural beat stimulation. The mood assessment scores were collected from sessions 1, 4 and 8, respectively. With respect to the Gamma 40 Hz entrainment frequency population, we observed a mean improvement in cognitive scores, elevating from 75% average to 85% average upon conclusion of the experimentation at weak statistical significance ($$\alpha$$ α = 0.10, p = 0.076). Similarly, memory score improvements at a greater significance ($$\alpha$$ α = 0.05, p = 0.0027) were noted, elevating from an average of 87% to 95%. In pertinence to the mood scores, a negative correlation across all populations were noted, inferring an overall increase in mood due to lower scores correlating with elevated mood. Finally, correlation analysis revealed a stronger R$$^2$$ 2 value (0.9838) within the 40 Hz group between sessions as well as mood score when compared across the entire frequency group cohort.

Evaluation of 99mTc‐L‐methionine brain SPECT for detection of recurrent brain tumor: a pilot study with radiological and pathological correlation

2004 ◽  
Vol 45 (6) ◽  
pp. 649-657 ◽  
Author(s):  
S. Barai ◽  
G. P. Bandopadhayaya ◽  
P. K. Julka ◽  
S. S. Kale ◽  
A. Malhotra ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Pilot Study ◽  
Brain Spect ◽  
Pathological Correlation ◽  
Recurrent Brain Tumor
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