Urokinase secretion by gastrointestinal adenocarcinoma.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15529-e15529
Author(s):  
Larisa S. Kozlova ◽  
Oleg I. Kit ◽  
Elena M. Frantsiyants ◽  
Yuriy A. Gevorkyan ◽  
Andrey A. Maslov ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Statistical Analysis ◽  
Plasminogen Activator ◽  
Sigmoid Colon ◽  
Malignant Tumors ◽  
Pancreatic Head ◽  
Head Cancer ◽  
Pancreatic Head Cancer ◽  
Resection Line ◽  
Colon And Rectum

e15529 Background: The serine protease urokinase plasminogen activator (uPA) plays an important role in growth and invasion of malignant tumors. The purpose of the study was a comparative analysis of uPA activity (uPA-act) and its antigen (uPA-Ag) content in adenocarcinoma (A) of the esophagus (EA), stomach (SA), pancreatic head (PHA), sigmoid colon (SCA) and rectum (RA). Methods: Tissues of A, perifocal tissues (PT) and resection line tissues were studied by ELISA in 144 patients (39-73 years) with EA (n = 12, G2, T2-3N0-1M0), SA (n = 28, G2, T2-3N0-1M0), PHA (n = 46, G2, Т2-4N0M0), SCA (n = 31, G2, T2-3N0-1M0) and RA (n = 26, G2,T2-3N0-1M0). Statistical analysis was performed using the Statistica 10 program. Results: The levels of uPA-Ag in gastrointestinal A decreased from SA to PHA: SA˃RA˃SCA˃EA˃PHA (p < 0.01). The uPA-Ag levels in A were higher than in the resection line in all cases (p < 0.01). PT levels of uPA-Ag decreased from SA to PHA: SA˃SCA˃RA˃EA˃PHA (p < 0.01). In EA and PHA, PT levels of uPA-Ag were lower than in resection line tissues (p < 0.01), while in SA, SCA and RA they were higher (p < 0.01). Levels of uPA-act were similar in SA and SCA, while in EA and RA they were 1.2 (p = 0.4324) and 1.3 (p = 0.4012) times lower, and in PHA – 40.0-52.5 times lower (p < 0.01) compared to all A samples. The uPA-act in PT was the highest in SCA; 1.4 times lower in SA and RA; 1.7 times lower in EA; 30.9 times lower in PHA. The levels in PT were higher than in the resection line in all cases (p < 0.01). The resection line tissues in EA showed the maximal uPA-Ag content, while their uPA-act was similar to that in other tumors. Levels of uPA-Ag and uPA-act in resection line tissues in other tumors varied but were comparable. Estimated uPA-Ag/uPA-act coefficients in the resection line in SCA and RA were 20.4 and 29.5, respectively; in EA and PHA – 102.0 and 34.8, respectively. Conclusions: Adenocarcinomas of the esophagus, stomach, pancreatic head, sigmoid colon and rectum secrete uPA-Ag and uPA-act into surrounding tissues. The rate of uPA-Ag secretion by the tumor and its activation into uPA-act in pancreatic head cancer differ from that in other tumors.

scholarly journals Inappropriate Secretion of Antidiuretic Hormone after Pancreatoduodenectomy for Pancreatic Head Cancer: A Case Report and Literature Review

2021 ◽  
pp. 134-140
Author(s):  
Nozomi Karakuchi ◽  
Ichiro Ohmori ◽  
Masashi Inoue ◽  
Kazuhiro Toyota ◽  
Tadateru Takahashi
Keyword(s):  
Pancreatic Cancer ◽  
Antidiuretic Hormone ◽  
Malignant Tumors ◽  
Early Stage ◽  
Gastrointestinal Surgery ◽  
Gastrointestinal Symptoms ◽  
Pancreatic Head ◽  
Head Cancer ◽  
Pancreatic Head Cancer ◽  
Inappropriate Secretion

Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a disease that leads to dilute hyponatremia through excessive secretion of antidiuretic hormone. SIADH has various causes, including ectopic ADH-producing tumors, drug properties, and can be idiopathic. But there have been very few reports of cases in which SIADH has developed after surgery for malignant tumors. In addition, few cases have been reported where this disease has developed after surgery for pancreatic cancer, because the symptoms of hyponatremia are non-specific. These symptoms are particularly gastrointestinal symptoms; therefore, it is difficult to differentiate them, even if SIADH has developed after gastrointestinal surgery. The patient in our case was an 80-year-old woman. She had persistent epigastralgia and left back pain. Imaging studies revealed a tumor in the head of the pancreas, which was diagnosed as pancreatic head cancer. We performed subtotal stomach-preserving pancreatoduodenectomy. After the operation, she complained of appetite loss and general fatigue. Her serum sodium levels decreased to 109 mEq/L on postoperative day 11. She was diagnosed with SIADH using the SIADH diagnostic criteria listed by the Japanese Ministry of Health, Labor and Welfare. We treated the patient with sodium supplementation for hyponatremia, and her symptoms ameliorated. After the event, she did not relapse with hyponatremia. This case is significant in that we performed differential diagnosis after major gastrointestinal surgery for pancreatic cancer and diagnosed SIADH at an early stage.

scholarly journals Current approaches to surgical treatment of pancreatic head cancer

2021 ◽  
Vol 12 (4) ◽  
pp. 5-13
Author(s):  
Maxim Yu. Kabanov ◽  
Nikolay I. Glushkov ◽  
Konstantin V. Sementsov ◽  
Anatoliy V. Skorodumov ◽  
Valentin V. Alekseev ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Surgical Intervention ◽  
Malignant Tumors ◽  
Pancreatic Head ◽  
Malignant Neoplasms ◽  
Extensive Experience ◽  
Head Cancer ◽  
Main Method ◽  
Pancreatic Head Cancer ◽  
The Past

Pancreatic cancer accounts for 810% of all cases of malignant tumors of the digestive organs and 5060% of pancreaticoduodenal malignant neoplasms. Over the past 30 years the incidence of pancreatic cancer in Russia has increased by 30%. The main method of treatment this category of patients requires surgical intervention. Extensive experience has been gained in using various types of surgical therapy. The review analyzes the results of modern studies on the efficacy and safety of the most common of them.

Clinical impact of preoperative tumour contact with superior mesenteric-portal vein in patients with resectable pancreatic head cancer

2021 ◽  
Author(s):  
Fabio Ausania ◽  
Santiago Sanchez-Cabus ◽  
Paula Senra del Rio ◽  
Alex Borin ◽  
Juan Ramon Ayuso ◽  
...  
Keyword(s):  
Portal Vein ◽  
Pancreatic Head ◽  
Clinical Impact ◽  
Head Cancer ◽  
Pancreatic Head Cancer

Percutaneous Palliation of Pancreatic Head Cancer: Randomized Comparison of ePTFE/FEP–Covered Versus Uncovered Nitinol Biliary Stents

2010 ◽  
Vol 34 (2) ◽  
pp. 352-361 ◽  
Author(s):  
Miltiadis Krokidis ◽  
Fabrizio Fanelli ◽  
Gianluigi Orgera ◽  
Dimitrios Tsetis ◽  
Ioannis Mouzas ◽  
...  
Keyword(s):  
Pancreatic Head ◽  
Biliary Stents ◽  
Head Cancer ◽  
Pancreatic Head Cancer

Embolization of the Replaced Common Hepatic Artery Before Surgery for Pancreatic Head Cancer: Report of a Case

Surgery Today ◽  
2004 ◽  
Vol 34 (7) ◽  
Author(s):  
Noriyuki Miyamoto ◽  
Yoshihisa Kodama ◽  
Hideho Endo ◽  
Tadashi Shimizu ◽  
Kazuo Miyasaka ◽  
...  
Keyword(s):  
Hepatic Artery ◽  
Pancreatic Head ◽  
Common Hepatic Artery ◽  
Head Cancer ◽  
Pancreatic Head Cancer ◽  
Replaced Common Hepatic Artery

scholarly journals Total mesopancreas excision for the treatment of pancreatic head cancer

2017 ◽  
Vol 8 (17) ◽  
pp. 3575-3584 ◽  
Author(s):  
Jingyong Xu ◽  
Xiaodong Tian ◽  
Yiran Chen ◽  
Yongsu Ma ◽  
Chang Liu ◽  
...  
Keyword(s):  
Pancreatic Head ◽  
Head Cancer ◽  
Pancreatic Head Cancer

scholarly journals Comparative Bioinformatical Analysis of Pancreatic Head Cancer and Pancreatic Body/Tail Cancer

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S54
Author(s):  
L. Yin ◽  
L. Xiao ◽  
Y. Gao ◽  
G. Wang ◽  
H. Gao ◽  
...  
Keyword(s):  
Pancreatic Head ◽  
Head Cancer ◽  
Pancreatic Head Cancer ◽  
Pancreatic Body ◽  
Bioinformatical Analysis

scholarly journals Management and Reconstruction of a Gastroesophageal Junction Adenocarcinoma Patient Three Years after Pancreaticoduodenectomy: A Surgical Puzzle

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Dionysios Dellaportas ◽  
James A. Gossage ◽  
Andrew R. Davies
Keyword(s):  
Gastroesophageal Junction ◽  
Pancreatic Head ◽  
Second Primary ◽  
Primary Cancer ◽  
Head Cancer ◽  
Gastrointestinal Malignancies ◽  
Pancreatic Head Cancer ◽  
Gastroesophageal Junction Adenocarcinoma ◽  
Gastrointestinal Reconstruction ◽  
Gastroesophageal Adenocarcinoma

Introduction. With the improving survival of cancer patients, the development of a secondary primary cancer is an increasingly common phenomenon. Extensive surgery during initial treatment may pose significant challenges to surgeons managing the second primary cancer.Case Presentation. A 69-year-old male, who had a pancreaticoduodenectomy three years ago for pancreatic head adenocarcinoma, underwent an uneventful extended total gastrectomy for gastroesophageal junctional adenocarcinoma. The reconstruction controversies and considerations are highlighted.Discussion. Genetic, environmental, and lifestyle factors are common for several gastrointestinal malignancies. However, the occurrence of a second unfavorable cancer such as gastroesophageal adenocarcinoma after pancreatic head cancer treatment is extremely uncommon. This clinical scenario possesses numerous difficulties for the surgeon, since surgical resection is the mainstay of treatment for both malignancies. Gastrointestinal reconstruction becomes challenging and requires careful planning and meticulous surgical technique along with sound intraoperative judgement.

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