Colorectal Cancer in the Adolescent and Young Adult Population

Colorectal cancer in the young adult population is of increasing incidence and concern. Genetic predisposition and heritable syndromes contribute to this trend, but perhaps more concerning is the majority of new diagnoses that involve no traceable genetic risk factors. Prevention and early recognition, with a high suspicion in the symptomatic young adult, are critical in attenuating recent trends. Clinical management requires coordinated multidisciplinary care from diagnosis to surveillance in order to ensure appropriate management. This review provides a summary of key aspects related to colorectal cancer in adolescents and young adults, including epidemiology, biology, genetics, clinical management, and prevention.

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Comparative Study of Colorectal Cancer Based on Tumor Location in Adolescent and Young Adult Population in Nepal

Nepalese Medical Journal ◽

10.3126/nmj.v3i2.33087 ◽

2020 ◽

Vol 3 (2) ◽

pp. 370-374

Author(s):

Rajeeb Kumar Deo ◽

Prakash G Chitalkar ◽

Srijan Malla ◽

Bikash Shrestha ◽

Kunda B Shah ◽

...

Keyword(s):

Colorectal Cancer ◽

Young Adult ◽

Adult Population ◽

Tumor Location ◽

Adolescent And Young Adult ◽

Colorectal Cancers ◽

Cancer Data ◽

Pain Abdomen ◽

Number Of Patients ◽

Young Adult Population

Introduction: Colorectal cancer in the Adolescent and Young Adult population are increasing and are characterized by a more advanced stage at diagnosis, poorer cell differentiation, higher signet ring histology, and left-sided colon location of the primary tumor. This study aims to compare colorectal cancer data in the Adolescent and Young Adult population-based on tumor location.Materials and Methods: This is a retrospective cross-sectional study of colorectal cancer in the Adolescent and Young Adult population from April 2017 to September 2020 in Shree Birendra Hospital. Data were collected for age, sex, clinical features, histology, TNM stage, colonoscopy finding, radiologic features, treatment, and follow-up status based on tumor location. Data were analyzed using Excel 2010 and SPSS v 17.Results: The total number of patients was 61 with the mean age of 32.36 ± 6.24 years. There was a male preponderance of 63.93%. Right-sided colorectal cancer was 24.59% while left-sided colorectal cancer was 75.41%. For right-sided colorectal cancers, the most common symptoms were pain abdomen (73.3%) and diarrhea (53.3%) while for left-sided colorectal cancers, it was pain abdomen (80.4%) and bleeding per rectum (45.7%). The most common histology was adenocarcinoma (95.08%) with moderately differentiated being most common in both locations. Surgery, radiation and chemotherapy for right-sided and left-sided colorectal cancer were 86.66%, 0.0%, 86.66% and 58.67%, 28.26%, 89.13% respectively.Conclusions: Left-sided colorectal cancer was more common in the Adolescent and Young Adult population in our study. There were signifi cant differences in the clinical presentation of colorectal cancer as per the tumor location.

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