Clinical Implications of the Phenomenon of Drug Resistance

2019 ◽  
pp. 111-127
Author(s):  
J. H. Goldie
Keyword(s):  
Drug Resistance ◽  
Clinical Implications

Molecular mechanisms and clinical implications of miRNAs in drug resistance of esophageal cancer

2017 ◽  
Vol 11 (12) ◽  
pp. 1151-1163 ◽  
Author(s):  
Wanli Yang ◽  
Jiaojiao Ma ◽  
Wei Zhou ◽  
Xin Zhou ◽  
Bo Cao ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Esophageal Cancer ◽  
Molecular Mechanisms ◽  
Clinical Implications

Clinical implications of HIV-1 drug resistance in the neurological compartment

2003 ◽  
Vol 35 (sup106) ◽  
pp. 41-44 ◽  
Author(s):  
Andrea Antinori ◽  
Antonella Cingolani ◽  
Maria Letizia Giancola ◽  
Federica Forbici ◽  
Andrea De Luca ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Clinical Implications ◽  
Hiv 1

Clinical implications of stopping nevirapine-based antiretroviral therapy: relative pharmacokinetics and avoidance of drug resistance

HIV Medicine ◽  
2004 ◽  
Vol 5 (3) ◽  
pp. 180-184 ◽  
Author(s):  
NE Mackie ◽  
S Fidler ◽  
N Tamm ◽  
JR Clarke ◽  
D Back ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Clinical Implications

Monitoring HIV drug resistance in treatment-naive individuals: molecular indicators, epidemiology and clinical implications

HIV Therapy ◽  
2009 ◽  
Vol 3 (4) ◽  
pp. 369-390 ◽  
Author(s):  
Emmanouil Magiorkinis ◽  
Maria Detsika ◽  
Angelos Hatzakis ◽  
Dimitrios Paraskevis
Keyword(s):  
Drug Resistance ◽  
Clinical Implications ◽  
Hiv Drug Resistance ◽  
Treatment Naïve ◽  
Molecular Indicators

scholarly journals Levels of phenotypic resistance and the pattern of gene mutations of M. tuberculosis

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Nelly Ciobanu ◽  
◽  
Alexandru Codreanu ◽  
Nadejda Turcan ◽  
Ecaterina Noroc ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Gene Mutations ◽  
Resistance Testing ◽  
Clinical Implications ◽  
Accurate Data ◽  
Genotypic Resistance ◽  
Phenotypic Resistance ◽  
Treatment Regimens ◽  
Results Of Treatment ◽  
Different Types

The adjustment of the minimum inhibitory concentrations for anti-tuberculosis drugs used in classical cultivation methods and the obtaining of more accurate data on the level of drug resistance, makes it possible to evaluate cases with different results to phenotypic and genotypic methods of anti-tuberculosis resistance testing. The evaluation of different types of genotypic resistance, with the description of mutations that confer low or high resistance, is consistent with the level of phenotypic resistance, and also makes it possible to adjust treatment regimens, which ultimately will positively influence the duration and results of treatment. Whenever testing of M. tuberculosis resistance by molecular methods allows, the results should be reported with the specific mutations detected and the description of the clinical implications of this mutation.

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