Biological and Clinical Significance of MYCN Amplification in Human Neuroblastomas

2020 ◽  
pp. 383-396
Author(s):  
Garrett M. Brodeur
Keyword(s):  
Clinical Significance ◽  
Mycn Amplification

Clinical Significance of MYCN Amplification and Ploidy in Favorable-Stage Neuroblastoma: A Report From the Children's Oncology Group

2008 ◽  
Vol 26 (6) ◽  
pp. 913-918 ◽  
Author(s):  
Jennifer Schneiderman ◽  
Wendy B. London ◽  
Garrett M. Brodeur ◽  
Robert P. Castleberry ◽  
A. Thomas Look ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Clinical Significance ◽  
Survival Rates ◽  
Mycn Amplification ◽  
Oncology Group ◽  
Free Survival ◽  
Kaplan Meier ◽  
Stage Disease ◽  
Pediatric Oncology Group

Purpose MYCN amplification is rarely detected in patients with favorable-stage neuroblastoma (NB). To determine the clinical significance of MYCN amplification in children with favorable-stage NB, we performed a retrospective review of data from the Pediatric Oncology Group (POG) biology study 9047. Patients and Methods MYCN status, tumor cell ploidy, treatment, and outcome of patients with stage A, B, or Ds NB, enrolled on POG 9047 between 1990 and 1999 were analyzed. Event-free survival (EFS) and overall (OS) survival rates were analyzed using the Kaplan-Meier method. Results Of the 1,667 patients enrolled on POG 9047, 643 had favorable-stage disease. Of these, follow-up data were available on 568 (34%) with stage A, B, or Ds disease and normal MYCN copy number, and 32 (1.9%) patients with MYCN-amplified, stage A, B, or Ds tumors. Within the cohort lacking MYCN amplification, the 7-year EFS and OS rates (± SE) were 91% ± 1% and 96% ± 1%, respectively. Patients with MYCN amplification had significantly worse EFS and OS (50% ± 9% and 59% ± 9%, respectively, P < .0001). Within the cohort of children with MYCN amplification, the 7-year EFS and OS rates were 80% ± 10% and 87% ± 9%, respectively for patients with hyperdiploid tumors and 25% ± 11% and 38% ± 12% for patients with diploid/hypodiploid NBs (P = .0063 and P = .0074, respectively). Conclusion Tumor cell ploidy may be a clinically useful factor for prognostication and treatment stratification in children with MYCN-amplified, favorable-stage NB tumors.

Clinical significance of MYCN amplification in patients with high-risk neuroblastoma

2018 ◽  
Vol 65 (10) ◽  
pp. e27257 ◽  
Author(s):  
Ji Won Lee ◽  
Meong Hi Son ◽  
Hee Won Cho ◽  
Young Eun Ma ◽  
Keon Hee Yoo ◽  
...  
Keyword(s):  
High Risk ◽  
Clinical Significance ◽  
Mycn Amplification

scholarly journals Differential Clinical Significance of Neurotrophin-3 Expression according to MYCN Amplification and TrkC Expression in Neuroblastoma

2019 ◽  
Vol 34 (39) ◽  
Author(s):  
Eunseop Seo ◽  
Jung-Sun Kim ◽  
Young Eun Ma ◽  
Hee Won Cho ◽  
Hee Young Ju ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Mycn Amplification ◽  
Neurotrophin 3

Clinical significance of cathepsin E in pancreatic juice in the diagnosis of pancreatic ductal adenocarcinoma

2000 ◽  
Vol 15 (11) ◽  
pp. 1333-1338 ◽  
Author(s):  
Koji Uno ◽  
Takeshi Azuma ◽  
Masatsugu Nakajima ◽  
Kenjiro Yasuda ◽  
Takanobu Hayakumo ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Clinical Significance ◽  
Pancreatic Juice ◽  
Ductal Adenocarcinoma ◽  
Cathepsin E

Diversity of Helicobacter pylori CagA gene and its clinical significance

2001 ◽  
Vol 120 (5) ◽  
pp. A56-A56
Author(s):  
T AZUMA ◽  
Y ITO ◽  
M DOJO
Keyword(s):  
Helicobacter Pylori ◽  
Clinical Significance ◽  
Caga Gene
Sign in / Sign up

Export Citation Format

Share Document