Experience with Praziquantel Treatment

2020 ◽  
pp. 29-34
Author(s):  
Dietrich H. G. Wegner
Keyword(s):  
Praziquantel Treatment

Observation of mucosal pathology after praziquantel treatment in experimental Fibricola seoulensis infection in rats

1989 ◽  
Vol 27 (1) ◽  
pp. 35 ◽  
Author(s):  
S H Lee ◽  
B I Kim ◽  
S T Hong ◽  
W M Sohn ◽  
J Y Chai
Keyword(s):  
Praziquantel Treatment

scholarly journals Evaluation of microscopy, serology, circulating anodic antigen (CAA), and eosinophil counts for the follow-up of migrants with chronic schistosomiasis: a prospective cohort study

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Francesca Tamarozzi ◽  
Tamara Ursini ◽  
Pytsje T. Hoekstra ◽  
Ronaldo Silva ◽  
Cecilia Costa ◽  
...  
Keyword(s):  
Post Treatment ◽  
Endemic Country ◽  
Active Infection ◽  
Positive Serology ◽  
Praziquantel Treatment ◽  
Positive Urine ◽  
Antibody Titers ◽  
Eosinophil Counts ◽  
Sera Samples

Abstract Background An accurate test for the diagnosis and post-treatment follow-up of patients with schistosomiasis is needed. We assessed the performance of different laboratory parameters, including the up-converting reporter particle technology lateral flow assay to detect circulating anodic antigen (UCP-LF CAA), for the post-treatment follow-up of schistosomiasis in migrants attending a dedicated outpatient clinic in a non-endemic country. Methods Routine anti-Schistosoma serology results and eosinophil counts were obtained of patients with positive urine/stool microscopy and/or PCR (confirmed cases) or only positive serology (possible cases), and at least one follow-up visit at 6 (T6) or 12 (T12) months after praziquantel treatment. All sera samples were tested with the UCP-LF CAA assay. Results Forty-eight patients were included, 23 confirmed and 25 possible cases. The percentage seropositivity and median antibody titers did not change significantly during follow-up. UCP-LF CAA was positive in 86.9% of confirmed and 20% of possible cases. The percentage positivity and median CAA levels decreased significantly post-treatment, with only two patients having positive CAA levels at T12. Conclusions The UCP-LF CAA assay proved useful for the diagnosis of active infection with Schistosoma spp. and highly valuable for post-treatment monitoring in migrants, encouraging the development of a commercial test.

scholarly journals The impact of Opisthorchis felineus infection and praziquantel treatment on the intestinal microbiota in children

Acta Tropica ◽  
2021 ◽  
Vol 217 ◽  
pp. 105835
Author(s):  
Tatiana S. Sokolova ◽  
Vyacheslav A. Petrov ◽  
Irina V. Saltykova ◽  
Yulia B. Dorofeeva ◽  
Alexander V. Tyakht ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Opisthorchis Felineus ◽  
Praziquantel Treatment ◽  
The Impact

Reversal of biliary tract abnormalities associated with Opisthorchis viverrini infection following praziquantel treatment

1993 ◽  
Vol 87 (2) ◽  
pp. 194-197 ◽  
Author(s):  
Eimorn Mairiang ◽  
Melissa R. Haswell-Elkins ◽  
Pisaln Mairiang ◽  
Paiboon Sithithaworn ◽  
David B. Elkins
Keyword(s):  
Biliary Tract ◽  
Opisthorchis Viverrini ◽  
Praziquantel Treatment ◽  
Viverrini Infection

scholarly journals Albendazole and praziquantel treatment in neurocysticercosis of the fourth ventricle

1997 ◽  
Vol 2 (2) ◽  
pp. E13
Author(s):  
Jefferson V. Proaño ◽  
Ignacio Madrazo ◽  
Luis García ◽  
Elia García-Torres ◽  
Dolores Correa
Keyword(s):  
Therapeutic Efficacy ◽  
Fourth Ventricle ◽  
Complete Disappearance ◽  
Praziquantel Treatment

The purpose of this study was to determine the therapeutic efficacy of albendazole and praziquantel administration in the treatment of neurocysticercosis of the fourth ventricle. The authors report the results obtained in 10 patients with cystic neurocysticercosis of the fourth ventricle who were treated with albendazole at a dosage of 15 mg/kg/day for 2 weeks. Because of the failure of albendazole treatment, two of the patients received an additional course of praziquantel at a dosage of 100 mg/kg/day for 2 weeks. A total of 16 courses of albendazole and two courses of praziquantel were administered to the 10 patients. In seven patients (70%), there was complete disappearance of the cyst, in two others (20%) there was an important decrease in the size of the cyst, and in one (10%), no change was seen. None of the patients had complications during the follow-up period of between 6 and 26 months (average 15.7 months). The authors postulate that a regimen of albendazole is the treatment of choice for this type of neurocysticercosis, although praziquantel may also be useful.

scholarly journals Schisto and Ladders version 2: a health educational board game to support compliance with school-based mass drug administration with praziquantel – a pilot study

2020 ◽  
Author(s):  
Cynthia Uchechukwu Ejike ◽  
Akinola Stephen Oluwole ◽  
Olaitan Olamide Omitola ◽  
Adedotun Ayodeji Bayegun ◽  
Islamiat Yetunde Shoneye ◽  
...  
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
Intervention Group ◽  
Control Group ◽  
Board Game ◽  
Control Groups ◽  
Group Discussions ◽  
School Based ◽  
Praziquantel Treatment ◽  
And Control

Abstract Background We redesigned the Schisto and Ladders health educational board game and evaluated its potential to encourage compliance to school-based mass drug administration with praziquantel. Methods Two hundred and seventy-five children from six schools who rejected praziquantel treatment were divided into intervention and control groups. Before the intervention, preassessment interviews were conducted on their knowledge about praziquantel treatment and schistosomiasis. The Schisto and Ladders version 2 game as an intervention, and the Snakes and Ladders game as a control, were played for 6 mo. Postassessment interviews, including focus group discussions, were conducted. Results At preassessment, 0/98 (0.0%) children in the intervention group had heard of praziquantel compared with 2/177 (1.1%) in the control group. Similarly, 0/98 (0.0%) children in the intervention group did not know that praziquantel does not kill compared with 4/177 (2.3%) in the control group. The postassessment showed that 53/78 (67.9%) in the intervention group were aware of praziquantel compared with 2/177 (1.1%) in the control group (p=0.000). Similarly, 53 (69.7%) in the intervention group knew about the safety of praziquantel compared with 0/177 (0.0%) in the control group (p=0.000). Sixty-four children (65.3%) from the intervention group sought praziquantel treatment after the trial. Conclusions Schisto and Ladders version 2 is a useful sensitisation tool with which to encourage compliance to praziquantel treatment in schools.

scholarly journals Quality assessment of praziquantel tablets sold in medicine stores in Kano Metropolis

2018 ◽  
Vol 11 (1) ◽  
pp. 208-210
Author(s):  
M.A. Gadanya ◽  
K.A. Ahmad
Keyword(s):  
Standard Dose ◽  
Poor Quality ◽  
Regulatory Agencies ◽  
Cure Rate ◽  
Quality Cost ◽  
Expiry Date ◽  
Drug Of Choice ◽  
Praziquantel Treatment ◽  
Control Programmes

The efficacy, availability, tolerable side effects and relative affordability of praziquantel makes it the drug of choice in the treatment and various control programmes of schistosomiasis in the endemic areas with excellent outcomes. However, there are reports of low cure rate with praziquantel observed by clinicians with various speculations on the likely causes. This study explored poor drug quality as a possible cause of praziquantel treatment failure in schistosomiasis. On the spot sampling of twelve different samples of praziquantel tablets from various patent medicine shops in Kano metropolis were assayed for active ingredient using British Pharmacopeia methods. Only 6 out of 12 (50%) of the praziquantel tablets studied were found to be acceptable of quality. Cost and number of months before expiry date were not found to be significantly associated with the quality of the drug. Poor quality praziquantel currently in the market may possibly explain failure of standard dose of the drug in the treatment of schistosomiasis. Therefore, it is recommended that additional vigilance by regulatory agencies is required to ensure quality drugs in the market.Keywords: Efficacy, Kano, praziquantel, quality, schistosomiasis

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