Blast damage study in blasthole open stope mining

2020 ◽  
pp. 451-451 ◽  
Author(s):  
Qian Liu ◽  
Glen Ludwig
Keyword(s):  
Blast Damage ◽  
Damage Study

New 2-Oxopyridine/2-Thiopyridine Derivatives Tethered to a Benzotriazole with Cytotoxicity on MCF7 Cell Lines and with Antiviral Activities

2020 ◽  
Vol 17 (2) ◽  
pp. 124-137 ◽  
Author(s):  
Adel Mahmoud Attia ◽  
Ahmed Ibrahin Khodair ◽  
Eman Abdelnasser Gendy ◽  
Mohammed Abu El-Magd ◽  
Yaseen Ali Mosa Mohamed Elshaier
Keyword(s):  
Dna Damage ◽  
Anticancer Agents ◽  
Active Compound ◽  
Docking Study ◽  
Base Pairs ◽  
Dna Base ◽  
Dna Base Pairs ◽  
Antiviral Activities ◽  
Active Methylene ◽  
Damage Study

Background:Perturbation of nucleic acids structures and confirmation by small molecules through intercalation binding is an intriguing application in anticancer therapy. The planar aromatic moiety of anticancer agents was inserted between DNA base pairs leading to change in the DNA structure and subsequent functional arrest.Objective:The final scaffold of the target compounds was annulated and linked to a benzotriazole ring. These new pharmacophoric features were examined as antiviral and anticancer agents against MCF7 and their effect on DNA damage was also assessed.Methods:A new series of fully substituted 2-oxopyridine/2-thioxopyridine derivatives tethered to a benzotriazole moiety (4a-h) was synthesized through Michael cyclization of synthesized α,β- unsaturated compounds (3a-e) with appropriate active methylene derivatives. The DNA damage study was assessed by comet assay. In silico DNA molecular docking was performed using Open Eye software to corroborate the experimental results and to understand molecule interaction at the atomic level.Results:The highest DNA damage was observed in Doxorubicin, followed by 4h, then, 4b, 4g, 4f, 4e, and 4d. The docking study showed that compound 4h formed Hydrogen Bonds (HBs) as a standard ligand with GSK-3. Compound 4h was the most active compound against rotavirus Wa, HAVHM175, and HSV strains with a reduction of 30%, 40%, and 70%, respectively.Conclusion:Compound 4h was the most active compound and could act as a prospective lead molecule for anticancer agent.

scholarly journals Radiation damage study of organic molecules via laser-free ultrafast transmission electron microscopy

2021 ◽  
Vol 27 (S1) ◽  
pp. 3358-3359
Author(s):  
Hyeokmin Choe ◽  
Eric Montgomery ◽  
Ilya Ponomarev ◽  
June Lau ◽  
Yimei Zhu ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Radiation Damage ◽  
Organic Molecules ◽  
Transmission Electron ◽  
Damage Study

Correlations of blast damage to ground surface targets with explosion seismic effect

2004 ◽  
Vol 24 (7) ◽  
pp. 519-525 ◽  
Author(s):  
Qi Zhang ◽  
Da-chao Lin ◽  
Chun-hua Bai ◽  
Yan-yi Guo
Keyword(s):  
Ground Surface ◽  
Seismic Effect ◽  
Blast Damage

Laser-induced damage study of vacuum deposited perylene thin films

1988 ◽  
Vol 108 (1) ◽  
pp. K31-K34 ◽  
Author(s):  
A. Subbarayan ◽  
C. Balas Ubramanian ◽  
Sa. K. Narayandass
Keyword(s):  
Thin Films ◽  
Laser Induced Damage ◽  
Damage Study

Damage Study of Irradiated Tungsten using fast focus mode of a 2.2 kJ plasma focus

Vacuum ◽  
2017 ◽  
Vol 144 ◽  
pp. 14-20 ◽  
Author(s):  
S.H. Saw ◽  
V. Damideh ◽  
Jalil Ali ◽  
R.S. Rawat ◽  
P. Lee ◽  
...  
Keyword(s):  
Plasma Focus ◽  
Damage Study

LASER DAMAGE STUDY OF THIN FILMS

1967 ◽  
Author(s):  
Arthur F. Turner ◽  
Stanley J. Refermat
Keyword(s):  
Thin Films ◽  
Laser Damage ◽  
Damage Study
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