Passive Drug Delivery, Mechanisms of Uptake, and Intracellular Trafficking

2021 ◽  
pp. 129-152
Author(s):  
Parisa Foroozandeh ◽  
Siti Asmaa Mat Jusoh ◽  
Shaharum Shamsuddin
Keyword(s):  
Drug Delivery ◽  
Intracellular Trafficking

scholarly journals Intracellular Trafficking Network and Autophagy of PHBHHx Nanoparticles and their Implications for Drug Delivery

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Xiangyu Sun ◽  
Cheng Cheng ◽  
Jinxie Zhang ◽  
Xing Jin ◽  
Shuqing Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Intracellular Trafficking

scholarly journals Brain-Targeting Mechanisms of Lactoferrin-Modified DNA-Loaded Nanoparticles

2009 ◽  
Vol 29 (12) ◽  
pp. 1914-1923 ◽  
Author(s):  
Rongqin Huang ◽  
Weilun Ke ◽  
Liang Han ◽  
Yang Liu ◽  
Kun Shao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Intracellular Trafficking ◽  
Drug Delivery Systems ◽  
Brain Targeting ◽  
Brain Capillary ◽  
Modified Dna ◽  
Targeting Delivery ◽  
Capillary Endothelial Cells ◽  
First Time ◽  
The Brain

Ligand-mediated brain-targeting drug delivery is one of the focuses at present. Elucidation of exact targeting mechanisms serves to efficiently design these drug delivery systems. In our previous studies, lactoferrin (Lf) was successfully exploited as a brain-targeting ligand to modify cationic dendrimer-based nanoparticles (NPs). The mechanisms of Lf-modified NPs to the brain were systematically investigated in this study for the first time. The uptake of Lf-modified vectors and NPs by brain capillary endothelial cells (BCECs) was related to clathrin-dependent endocytosis, caveolae-mediated endocytosis, and macropinocytosis. The intracellular trafficking results showed that Lf-modified NPs could rapidly enter the acidic endolysosomal compartments within 5 mins and then partly escape within 30 mins. Both Lf-modified vectors and NPs showed higher blood–brain barrier-crossing efficiency than unmodified counterparts. All the results suggest that both receptor- and adsorptive-mediated mechanisms contribute to the cellular uptake of Lf-modified vectors and NPs. Enhanced brain-targeting delivery could be achieved through the synergistic effect of the macromolecular polymers and the ligand.

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