Application of Natural, Semi-synthetic, and Synthetic Biopolymers used in Drug Delivery Systems Design

2016 ◽  
pp. 38-65 ◽  
Author(s):  
Javier Sartuqui ◽  
Noelia D’Elía ◽  
A Noel ◽  
Luciano Benedini
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Systems Design ◽  
Delivery Systems

Recent Advances on Cellulose-Based Nano-Drug Delivery Systems: Design of Prodrugs and Nanoparticles

2019 ◽  
Vol 26 (14) ◽  
pp. 2410-2429 ◽  
Author(s):  
Lin Dai ◽  
Chuanling Si
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Low Cost ◽  
Drug Loading ◽  
Scale Up ◽  
Physicochemical Characterization ◽  
Systems Design ◽  
Delivery Systems ◽  
Recent Advances ◽  
Nano Drug Delivery

Background:Cellulose being the first abundant biopolymers in nature has many fascinating properties, including low-cost, good biodegradability, and excellent biocompatibility, which made cellulose a real potential material to create nano-drug delivery systems (nano-DDS). This review aims to present and discuss some remarkable recent advances on the drug delivery applications of cellulosebased prodrugs and nanoparticles.Methods:By searching the research literatures over last decade, a variety featured studies on cellulosebased nano-DDS were summarized and divided into prodrugs, prodrug nanoparticles, solid or derivative nanopartilces, amphiphilic copolymer nanoparticles, and polyelectrolyte complex nanoparticles. Various methods employed for the functionalization, pharmacodynamic actions and applications were described and discussed.Results:Many types of cellulose-based nano-DDS can ensure efficient encapsulation of various drugs and then overcome the free drug molecule shortcomings. Among all the method described, cellulosebased amphiphilic nanoparticles are most frequently used. These formulations have the higher drug loading capability, a simple and flexible way to achieve multi-functional. Apart from hydrophilic or hydrophobic modification, cellulose or its derivatives can form nanoparticles with different small molecules and macromolecules, leading to a large spectrum of cellulose-based nano-DDS and providing some unexpected advantages.Conclusion:Thorough physicochemical characterization and profound understanding of interactions of the cellulose-based nano-DDS with cells and tissues is indispensable. Moreover, studies toward technics parameter optimization and scale up from the laboratory to production level should be undertaken. The development of intravenous and orally applicable cellulose-based nano-DDS will be an important research area, and these systems will have more commercial status in the market.

Multifunctional Dendritic Drug Delivery Systems: Design, Synthesis, Controlled and Triggered Release

2008 ◽  
Vol 8 (14) ◽  
pp. 1204-1224 ◽  
Author(s):  
Constantinos Paleos ◽  
Dimitris Tsiourvas ◽  
Zili Sideratou ◽  
Leto Tziveleka
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Systems Design ◽  
Delivery Systems ◽  
Triggered Release ◽  
Design Synthesis

Self-emulsifying drug delivery systems: Design of a novel vaginal delivery system for curcumin

2017 ◽  
Vol 115 ◽  
pp. 268-275 ◽  
Author(s):  
S. Köllner ◽  
I. Nardin ◽  
R. Markt ◽  
J. Griesser ◽  
F. Prüfert ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Vaginal Delivery ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Systems Design ◽  
Delivery Systems

Olmesartan Medoxomil-Loaded Self-Nanoemulsifying Drug Delivery Systems: Design, In-Vitro Characterization, and Pharmacokinetic Assessments in Rabbits Via LC-MS/MS

2017 ◽  
Vol 7 (03) ◽  
Author(s):  
El-Assal M. I. A. ◽  
El-Gendy M. A. ◽  
Tadros M. I. ◽  
El-Gazayerly O. N.
Keyword(s):  
Drug Delivery ◽  
Zeta Potential ◽  
Drug Delivery Systems ◽  
Oral Absorption ◽  
Systems Design ◽  
Olmesartan Medoxomil ◽  
Delivery Systems ◽  
Log P ◽  
Polyethylene Glycol 400

Olmesartan medoxomil (OLM) is a lipophilic (log P = 4.31) antihypertensive drug suffering from limited oral bioavailability in humans (26%) due to its low aqueous solubility, uncontrolled enzymatic conversion to the active metabolite (olmesartan; OL) and efflux by drug resistance pumps. Surmounting such limitations via incorporation of OLM into self-nanoemulsifying drug delivery systems (SNEDDS). Based on OLM-equilibrium solubility studies in various oils, surfactants and co-surfactants, Capmul® MCM, Tween® 20, Cremophor® EL and polyethylene glycol-400 (PEG) were combined in different ratios to plot ternary phase diagrams. OLM-loaded SENDDS were developed and evaluated for particle size, polydispersity index (PDI), zeta potential, self-emulsification time, morphology, drug released percentages after 5-min (Q5min%), 1-hour (Q1h%) and dissolution efficiency percentages (DE1h%). The OL pharmacokinetics from SNEDDS (F6) and Benicar® tablets were evaluated (LC-MS/MS) in rabbits. Spherical OLM-loaded SNEDDS were developed. The best-achieved SNEDDS (F6) showed short emulsification time (13 s), fine droplet size (60.00 nm), low PDI (0.25), negative zeta potential (-14.4 mV), promising dissolution parameters; Q5min% (29.78%), Q1h% (66.69%) and DE1h%(47.96%) and enhanced in vivo absorption characteristics; shorter Tmax, higher Cmax and larger AUC(0−48h; suggesting its potential for the enhancement of the oral absorption of practically insoluble drugs; like OLM.

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