Localization of Steroid Binding in Prostatic Carcinoma by Histochemistry: Therapeutic Implications *

2018 ◽  
pp. 93-112
Author(s):  
Louis P. Pertschuk ◽  
Richard J. Macchia ◽  
Karen B. Eisenberg
Keyword(s):  
Prostatic Carcinoma ◽  
Therapeutic Implications ◽  
Steroid Binding

Heterogeneity of Steroid Binding Sites in Prostatic Carcinoma: Morphological Demonstration and Clinical Implications

1985 ◽  
Vol 134 (4) ◽  
pp. 840-841
Author(s):  
L.P. Pertschuk ◽  
K.B. Eisenberg ◽  
R.J. Macchia ◽  
J.G. Feldman
Keyword(s):  
Binding Sites ◽  
Prostatic Carcinoma ◽  
Clinical Implications ◽  
Steroid Binding

Heterogeneity of steroid binding sites in prostatic carcinoma: Morphological demonstration and clinical implications

The Prostate ◽  
1985 ◽  
Vol 6 (1) ◽  
pp. 35-47 ◽  
Author(s):  
Louis P. Pertschuk ◽  
Karen B. Eisenberg ◽  
Richard J. Macchia ◽  
Joseph G. Feldman
Keyword(s):  
Binding Sites ◽  
Prostatic Carcinoma ◽  
Clinical Implications ◽  
Steroid Binding

Polyamines and Prostatic Carcinoma: Clinical and Therapeutic Implications

1993 ◽  
Vol 24 (1) ◽  
pp. 124-131 ◽  
Author(s):  
B. Cipolla ◽  
F. Guillé ◽  
J.-Ph. Moulinoux ◽  
V. Quemener ◽  
F. Staerman ◽  
...  
Keyword(s):  
Prostatic Carcinoma ◽  
Therapeutic Implications

Prostatic Acid Phosphatase (PAP) Differentiated Ultracytochemically from Lysosomal Acid Phosphate in the Rat with a PAP/Specific Substrate, Phosphorylcholine

1975 ◽  
Vol 33 ◽  
pp. 450-451
Author(s):  
W. Allen Shannon ◽  
José A. Serrano ◽  
Hannah L. Wasserkrug ◽  
Anna A. Serrano ◽  
Arnold M. Seligman
Keyword(s):  
Acid Phosphatase ◽  
Phosphate Buffer ◽  
Prostatic Carcinoma ◽  
Prostatic Acid Phosphatase ◽  
Chemotherapeutic Agents ◽  
Specific Substrate ◽  
Acid Phosphate ◽  
Lysosomal Acid ◽  
Design And Synthesis ◽  
New Chemotherapeutic Agents

During the design and synthesis of new chemotherapeutic agents for prostatic carcinoma based on phosphorylated agents which might be enzyme-activated to cytotoxicity, phosphorylcholine, [(CH3)3+NCH2CH2OPO3Ca]Cl-, has been indicated to be a very specific substrate for prostatic acid phosphatase (PAP). This phenomenon has led to the development of specific histochemical and ultracytochemical methods for PAP using modifications of the Gomori lead method for acid phosphatase. Comparative histochemical results in prostate and kidney of the rat have been published earlier with phosphorylcholine (PC) and β-glycerophosphate (βGP). We now report the ultracytochemical results.Minced tissues were fixed in 3% glutaraldehyde-0.1 M phosphate buffered (pH 7.4) for 1.5 hr and rinsed overnight in several changes of 0.05 M phosphate buffer (pH 7.0) containing 7.5% sucrose. Tissues were incubated 30 min to 2 hr in Gomori acid phosphatase medium (2) containing 0.1 M substrate, either PC or βGP.

Pregabalin and gabapentin treatment in MS patients: Clinical experiences and therapeutic implications

2011 ◽  
Vol 42 (01) ◽  
Author(s):  
S. Bittner ◽  
K.G. Höhn ◽  
K. Göbel ◽  
H. Wiendl ◽  
S.G. Meuth
Keyword(s):  
Clinical Experiences ◽  
Therapeutic Implications

Changes in Adrenocortical Function with Aging and Therapeutic Implications

1999 ◽  
Vol Volume 17 (Number 4) ◽  
pp. 0327-0338 ◽  
Author(s):  
Andrew J. Harper ◽  
John E. Buster ◽  
Peter R. Casson
Keyword(s):  
Adrenocortical Function ◽  
Therapeutic Implications
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