Use of Intravenous Immunoglobulins for the Prevention and Treatment of Viral Infections in Solid Organ Transplantation

1997 ◽  
pp. 133-134
Keyword(s):  
Organ Transplantation ◽  
Viral Infections ◽  
Solid Organ Transplantation ◽  
Intravenous Immunoglobulins ◽  
Solid Organ ◽  
Prevention And Treatment

Cytomegalovirus in Solid Organ Transplant Recipients: Clinical Updates, Challenges and Future Directions

2020 ◽  
Vol 26 (28) ◽  
pp. 3497-3506
Author(s):  
Raymund R. Razonable
Keyword(s):  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Cmv Infection ◽  
Future Directions ◽  
Prevention And Treatment ◽  
Solid Organ Transplant Recipients

Cytomegalovirus is the classic opportunistic infection after solid organ transplantation. This review will discuss updates and future directions in the diagnosis, prevention and treatment of CMV infection in solid organ transplant recipients. Antiviral prophylaxis and pre-emptive therapy are the mainstays of CMV prevention, but they should not be mutually exclusive and each strategy should be considered depending on a specific situation. The lack of a widely applicable viral load threshold for diagnosis and preemptive therapy is emphasized as a major factor that should pave the way for an individualized approach to prevention. Valganciclovir and intravenous ganciclovir remain as drugs of choice for CMV management, and strategies for managing drug-resistant CMV infection are enumerated. There is increasing use of CMV-specific cell-mediated immune assays to stratify the risk of CMV infection after solid organ transplantation, and their potential role in optimizing CMV prevention and treatment efforts is discussed.

The high-risk donor: viral infections in solid organ transplantation

2008 ◽  
Vol 13 (4) ◽  
pp. 400-404 ◽  
Author(s):  
Andrew L Singer ◽  
Lauren M Kucirka ◽  
Ruth Namuyinga ◽  
Colleen Hanrahan ◽  
Aruna K Subramanian ◽  
...  
Keyword(s):  
High Risk ◽  
Organ Transplantation ◽  
Viral Infections ◽  
Solid Organ Transplantation ◽  
Solid Organ

scholarly journals Current Practices on Diagnosis, Prevention and Treatment of Post-Transplant Lymphoproliferative Disorder in Pediatric Patients after Solid Organ Transplantation: Results of ERN TransplantChild Healthcare Working Group Survey

Children ◽  
2021 ◽  
Vol 8 (8) ◽  
pp. 661
Author(s):  
Alastair Baker ◽  
Esteban Frauca Remacha ◽  
Juan Torres Canizales ◽  
Luz Yadira Bravo-Gallego ◽  
Emer Fitzpatrick ◽  
...  
Keyword(s):  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
Treatment Modalities ◽  
Multidisciplinary Teams ◽  
Solid Organ ◽  
Cross Sectional ◽  
Post Transplant ◽  
Pediatric Transplantation ◽  
Prevention And Treatment ◽  
Current Practices

(1) Background: Post-transplant lymphoproliferative disease (PTLD) is a significant complication of solid organ transplantation (SOT). However, there is lack of consensus in PTLD management. Our aim was to establish a present benchmark for comparison between international centers and between various organ transplant systems and modalities; (2) Methods: A cross-sectional questionnaire of relevant PTLD practices in pediatric transplantation was sent to multidisciplinary teams from 17 European center members of ERN TransplantChild to evaluate the centers’ approach strategies for diagnosis and treatment and how current practices impact a cross-sectional series of PTLD cases; (3) Results: A total of 34 SOT programs from 13 European centers participated. The decision to start preemptive treatment and its guidance was based on both EBV viremia monitoring plus additional laboratory methods and clinical assessment (61%). Among treatment modalities the most common initial practice at diagnosis was to reduce the immunosuppression (61%). A total of 126 PTLD cases were reported during the period 2012–2016. According to their histopathological classification, monomorphic lesions were the most frequent (46%). Graft rejection after PTLD remission was 33%. Of the total cases diagnosed with PTLD, 88% survived; (4) Conclusions: There is still no consensus on prevention and treatment of PTLD, which implies the need to generate evidence. This might successively allow the development of clinical guidelines.

scholarly journals Other viral infections in solid organ transplantation

2012 ◽  
Vol 30 ◽  
pp. 70-75
Author(s):  
Elisa Cordero ◽  
María Dolores Folgueira ◽  
María Ángeles Marcos ◽  
Francisco López Medrano
Keyword(s):  
Organ Transplantation ◽  
Viral Infections ◽  
Solid Organ Transplantation ◽  
Solid Organ
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