scholarly journals Non-CMV Viral Infections Following Solid-Organ Transplantation – Focus on Human T-Cell Lymphotropic Virus Type-1 and Human Herpesviruses-6,-7 and -8

2019 ◽  
Vol 3 (2) ◽  
pp. 1-1
Author(s):  
Katerina G. Oikonomou ◽  
◽  
Sarah Taimur ◽  
Keyword(s):  
T Cell ◽  
Organ Transplantation ◽  
Virus Type ◽  
Viral Infections ◽  
Solid Organ Transplantation ◽  
Solid Organ ◽  
Human T Cell ◽  
Human Herpesviruses

scholarly journals Posttransplant T-cell lymphoproliferative disorders--an aggressive, late complication of solid-organ transplantation

Blood ◽  
1996 ◽  
Vol 88 (9) ◽  
pp. 3626-3633 ◽  
Author(s):  
MN Hanson ◽  
VA Morrison ◽  
BA Peterson ◽  
KT Stieglbauer ◽  
VL Kubic ◽  
...  
Keyword(s):  
T Cell ◽  
Organ Transplantation ◽  
Virus Type ◽  
Late Complication ◽  
Solid Organ Transplantation ◽  
Lymphoproliferative Disorders ◽  
Solid Organ ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Human T Cell

T-cell non-Hodgkin's lymphomas are an uncommon occurrence after solid-organ transplantation. We describe a morphologically and immunophenotypically distinct group of T-cell lymphoproliferative disorders that occurred late in the course of six patients with solid-organ transplants. The patients ranged in age from 31 to 56 years (median, 43). Three were male; all were splenectomized. The interval from transplant to the diagnosis of lymphoma ranged from 4 to 26 years (median, 15). Symptoms at presentation were related to sites of involvement. Pulmonary, marrow, and CNS involvement were present in five, four, and one case, respectively. No patient had lymphadenopathy. Five patients had an elevated lactate dehydrogenase level (range, 226 to 4,880 IU/L; median, 1,220 IU/L). Five of six patients had a leukoerythroblastic reaction. All cases had large-cell histology and frequently contained cytoplasmic granules. Those cases tested expressed CD2, CD3, and CD8 and were negative for B-cell antigens. T-cell receptor beta- and gamma-chain genes were clonally rearranged in three of three and one of three cases, respectively. All T-cell posttransplant lymphoproliferative disorders (T-PTLDs) studied were negative for Epstein-Barr virus (EBV), human T-cell leukemia/lymphoma virus type 1 (HTLV-1), human T-cell leukemia/lymphoma virus type 2 (HTLV-2), and human herpes virus type 8 (HHV-8) genomes. Treatment with acyclovir (three patients) or chemotherapy (three patients) resulted in two responses. All patients had an aggressive course, with a median survival duration of 5 weeks. In conclusion, a clinically aggressive T-PTLD may be a late complication of solid-organ transplantation and does not appear to be related to EBV, HTLV-1, HTLV-2, or HHV-8 infection.

scholarly journals Human T Cell Lymphotrophic Virus 1/2 in Solid Organ Transplantation

2013 ◽  
Vol 13 (s4) ◽  
pp. 355-360 ◽  
Author(s):  
D. R. Kaul ◽  
J. A. Davis ◽  
Keyword(s):  
T Cell ◽  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
Solid Organ ◽  
Human T Cell

scholarly journals HLA-B*35 as a new marker for susceptibility to Human T-cell Lymphotropic Virus type 1 (HTLV-1) Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in patients living in Argentina

2020 ◽  
Author(s):  
Paula Benencio ◽  
Sindy A. Fraile Gonzalez ◽  
Nicolás Ducasa ◽  
Kimberly Page ◽  
Carolina A. Berini ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Viral Infections ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
T Lymphotropic Virus ◽  
Adult T Cell Leukemia ◽  
Human T Cell ◽  
High Proviral Load

Abstract Background: Human T lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV associated myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) and Adult T cell leukemia/lymphoma (ATLL), in around 2-5% of the infected individuals. Host genetic background might play a role in disease progression. Several previous studies across many countries report HLA haplotype to be one such factor. Here, we sequenced HLA-A, -B and -C of 72 individuals by Sequence-Based Typing (SBT), and compared the frequency of different alleles among ATLL patients, HAM/TSP patients, asymptomatic carriers and non-infected individuals living in Argentina.Results: The frequency of HLA-A, -B and -C alleles largely matched that of the general population in Argentina. We identified HLA-A*02 and HLA-B*35 as associated to protection from ATLL (p=0.037) and susceptibility to HAM/TSP (p<0.001), respectively. We also found a strong correlation between high proviral load (PVL) and disease (p=0.003), but were unable to identify any particular allele associated with high or low PVL.Conclusions: Our results match several previous reports that link HLA-A*02 and protection from disease. However, this is the first study associating HLA-B*35 to susceptibility to disease in HTLV-1, an allele that has been largely associated to different severity factors related to other viral infections, such as Human Immunodeficiency Virus (HIV-1) and Hepatitis B Virus (HBV).

scholarly journals HLA-B*35 as a new marker for susceptibility to Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in patients with Human T-cell Lymphotropic Virus type 1 (HTLV-1) in Argentina

2020 ◽  
Author(s):  
Paula Benencio ◽  
Sindy A. Fraile Gonzalez ◽  
Nicolás Ducasa ◽  
Kimberly Page ◽  
Carolina A. Berini ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Viral Infections ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
T Lymphotropic Virus ◽  
Adult T Cell Leukemia ◽  
Human T Cell ◽  
High Proviral Load

Abstract Background Human T lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV associated myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) and Adult T cell leukemia/lymphoma (ATLL), in around 2–5% of the infected individuals. Host genetic background might play a role in disease progression. Several previous studies across many countries report HLA haplotype to be one such factor. Here, we sequenced HLA-A, -B and -C of 73 individuals by Sequence-Based Typing (SBT), and compared the frequency of different alleles among ATLL patients, HAM/TSP patients, asymptomatic carriers and non-infected individuals in Argentina. Results The frequency of HLA-A, -B and -C alleles largely matched that of the general population in Argentina. We identified HLA-A*02 and HLA-B*35 as associated to protection from ATLL (p = 0.042) and susceptibility to HAM/TSP (p = 0.006), respectively. We also found a strong correlation between high proviral load (PVL) and disease (p = 0.0177), but were unable to identify any particular allele associated with high or low PVL. Conclusions Our results match several previous reports that link HLA-A*02 and protection from disease. However, this is the first study associating HLA-B*35 to susceptibility to disease in HTLV-1, an allele that has been largely associated to different severity factors related to other viral infections, such as Human Immunodeficiency Virus (HIV-1) and Hepatitis B Virus (HBV).

scholarly journals Human T-lymphotropic virus type 1 infection and solid organ transplantation

2018 ◽  
Vol 28 (2) ◽  
pp. e1970 ◽  
Author(s):  
Graham P. Taylor
Keyword(s):  
Organ Transplantation ◽  
Virus Type ◽  
Solid Organ Transplantation ◽  
Solid Organ ◽  
T Lymphotropic Virus

Prevention and therapy of viral infections in patients with solid organ transplantation

2021 ◽  
Vol 39 (2) ◽  
pp. 87-97
Author(s):  
Jose Tiago Silva ◽  
Mario Fernández-Ruiz ◽  
José María Aguado
Keyword(s):  
Organ Transplantation ◽  
Viral Infections ◽  
Solid Organ Transplantation ◽  
Solid Organ ◽  
Prevention And Therapy

Pain, psychoaffective symptoms, and quality of life in human T cell lymphotropic virus type 1 (HTLV-1): a cross-sectional study

2021 ◽  
Author(s):  
Dislene Nascimento dos Santos ◽  
Katia Nunes Sá ◽  
Fernanda C. Queirós ◽  
Alaí Barbosa Paixão ◽  
Kionna Oliveira Bernardes Santos ◽  
...  
Keyword(s):  
Quality Of Life ◽  
T Cell ◽  
Virus Type ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Human T Cell

scholarly journals Correlation between LTR point mutations and proviral load levels among Human T cell Lymphotropic Virus type 1 (HTLV-1) asymptomatic carriers

2011 ◽  
Vol 8 (1) ◽  
pp. 535 ◽  
Author(s):  
Walter K Neto ◽  
Antonio C Da-Costa ◽  
Ana Carolina S de Oliveira ◽  
Vanessa P Martinez ◽  
Youko Nukui ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Proviral Load ◽  
Point Mutations ◽  
Asymptomatic Carriers ◽  
Human T Cell

Approaches for monitoring of non virus-specific and virus-specific T-cell response in solid organ transplantation and their clinical applications

2015 ◽  
Vol 70 ◽  
pp. 109-119 ◽  
Author(s):  
Sandra A. Calarota ◽  
Judith H. Aberle ◽  
Elisabeth Puchhammer-Stöckl ◽  
Fausto Baldanti
Keyword(s):  
T Cell ◽  
Organ Transplantation ◽  
Cell Response ◽  
Solid Organ Transplantation ◽  
Clinical Applications ◽  
T Cell Response ◽  
Solid Organ
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