Biological and Engineering Considerations for Developing Tumor-Targeting Metallic Nanoparticle Drug-Delivery Systems

The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.

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“Smart” Nanocarriers: A New Paradigm for Tumor Targeting Drug Delivery Systems

Drug Delivery Letters ◽

10.2174/2210304x11101010067 ◽

2011 ◽

Vol 1 (1) ◽

pp. 67-84

Author(s):

Zhigang Hu ◽

Fei Huo ◽

Yi Zhang ◽

Chunyang Chen ◽

Kehua Tu ◽

...

Keyword(s):

Drug Delivery ◽

Tumor Targeting ◽

Drug Delivery Systems ◽

Delivery Systems ◽

New Paradigm

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Micro and nanoparticle drug delivery systems for preventing allotransplant rejection

Clinical Immunology ◽

10.1016/j.clim.2015.04.013 ◽

2015 ◽

Vol 160 (1) ◽

pp. 24-35 ◽

Cited By ~ 27

Author(s):

James D. Fisher ◽

Abhinav P. Acharya ◽

Steven R. Little

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Nanoparticle Drug Delivery

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Biomimetic Drug Delivery Systems Oriented by Biological Function in Tumor Targeting

Current Drug Targets ◽

10.2174/1389450122666210114095859 ◽

2021 ◽

Vol 22 ◽

Author(s):

Rui Wang ◽

Xianyi Sha

Keyword(s):

Drug Delivery ◽

Tumor Targeting ◽

Drug Delivery Systems ◽

Biological Function ◽

Delivery Systems ◽

Biological Functions ◽

Simple Preparation ◽

Targeting Delivery ◽

Clinical Transformation ◽

Endogenous Substances

: The emergence of nanoscale drug delivery systems provides new opportunities for targeting delivery of chemotherapeutic drugs and has achieved excellent results. In recent years, with the arising of the concept of intelligent drug delivery systems, the design and preparation of carriers have become more and more complicated, which is not conducive to clinical transformation. Researchers are gradually focusing on biomimetic nanoscale drug delivery systems, trying to combine the physicochemical properties of nanoscale carriers with the natural biological functions of endogenous substances, so as to boost tumor targeting delivery. In this article, we first classify and introduce biomimetic nanoscale drug delivery systems, and then emphasize their unique biological functions. The biomimetic nanoscale drug delivery systems have the advantages of simple preparation, powerful functions, and low immunogenicity, having a good application prospect.

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Self-assembled nanoparticle drug delivery systems from galactosylated polysaccharide–doxorubicin conjugate loaded doxorubicin

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2009.11.008 ◽

2010 ◽

Vol 46 (2) ◽

pp. 245-249 ◽

Cited By ~ 50

Author(s):

Yu Cao ◽

Ying Gu ◽

Hong Ma ◽

Jing Bai ◽

Lina Liu ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Nanoparticle Drug Delivery ◽

Self Assembled

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Nanoparticle Drug Delivery Systems for α-Mangostin

Nanotechnology Science and Applications ◽

10.2147/nsa.s243017 ◽

2020 ◽

Vol Volume 13 ◽

pp. 23-36 ◽

Cited By ~ 2

Author(s):

Nasrul Wathoni ◽

Agus Rusdin ◽

Keiichi Motoyama ◽

I Made Joni ◽

Ronny Lesmana ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Nanoparticle Drug Delivery

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Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems

Cancers ◽

10.3390/cancers11050640 ◽

2019 ◽

Vol 11 (5) ◽

pp. 640 ◽

Cited By ~ 70

Author(s):

Jihye Yoo ◽

Changhee Park ◽

Gawon Yi ◽

Donghyun Lee ◽

Heebeom Koo

Keyword(s):

Drug Delivery ◽

Surface Modification ◽

Small Molecules ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Active Targeting ◽

Target Cells ◽

Specific Receptors ◽

Nanoparticle Drug Delivery

Targeting nanoparticle (NP) carriers to sites of disease is critical for their successful use as drug delivery systems. Along with optimization of physicochemical properties, researchers have focused on surface modification of NPs with biological ligands. Such ligands can bind specific receptors on the surface of target cells. Furthermore, biological ligands can facilitate uptake of modified NPs, which is referred to as ‘active targeting’ of NPs. In this review, we discuss recent applications of biological ligands including proteins, polysaccharides, aptamers, peptides, and small molecules for NP-mediated drug delivery. We prioritized studies that have demonstrated targeting in animals over in vitro studies. We expect that this review will assist biomedical researchers working with NPs for drug delivery and imaging.

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