“Smart” Nanocarriers: A New Paradigm for Tumor Targeting Drug Delivery Systems

The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.

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Biological and Engineering Considerations for Developing Tumor-Targeting Metallic Nanoparticle Drug-Delivery Systems

Drugs and the Pharmaceutical Sciences - Nanoparticulate Drug Delivery Systems ◽

10.1201/9781420008449.ch10 ◽

2007 ◽

pp. 141-158 ◽

Cited By ~ 2

Author(s):

Giulio Paciotti ◽

Lawrence Tamarkin

Keyword(s):

Drug Delivery ◽

Tumor Targeting ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Metallic Nanoparticle ◽

Nanoparticle Drug Delivery

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Biomimetic Drug Delivery Systems Oriented by Biological Function in Tumor Targeting

Current Drug Targets ◽

10.2174/1389450122666210114095859 ◽

2021 ◽

Vol 22 ◽

Author(s):

Rui Wang ◽

Xianyi Sha

Keyword(s):

Drug Delivery ◽

Tumor Targeting ◽

Drug Delivery Systems ◽

Biological Function ◽

Delivery Systems ◽

Biological Functions ◽

Simple Preparation ◽

Targeting Delivery ◽

Clinical Transformation ◽

Endogenous Substances

: The emergence of nanoscale drug delivery systems provides new opportunities for targeting delivery of chemotherapeutic drugs and has achieved excellent results. In recent years, with the arising of the concept of intelligent drug delivery systems, the design and preparation of carriers have become more and more complicated, which is not conducive to clinical transformation. Researchers are gradually focusing on biomimetic nanoscale drug delivery systems, trying to combine the physicochemical properties of nanoscale carriers with the natural biological functions of endogenous substances, so as to boost tumor targeting delivery. In this article, we first classify and introduce biomimetic nanoscale drug delivery systems, and then emphasize their unique biological functions. The biomimetic nanoscale drug delivery systems have the advantages of simple preparation, powerful functions, and low immunogenicity, having a good application prospect.

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An Overview of Bioactive Natural Products-Based Nano-Drug Delivery Systems in Antitumor Chemotherapy

E3S Web of Conferences ◽

10.1051/e3sconf/202127103042 ◽

2021 ◽

Vol 271 ◽

pp. 03042

Author(s):

Yihao Niu

Keyword(s):

Drug Delivery ◽

Natural Products ◽

Chinese Medicine ◽

Tumor Targeting ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Selective Toxicity ◽

Bioactive Natural Products ◽

Nano Drug Delivery ◽

Antitumor Chemotherapy

Many bioactive natural products are derived from traditional Chinese medicine. Some of them showed good treatment potential in tumor chemotherapy. However, limited by the poorly solubility and non-selective toxicity of most of bioactive natural products, their antitumor efficacy could not be further applied in clinicals. Nano-drug delivery systems provided good platforms for bioactive natural products in antitumor treatment, and many tumor microenvironment-responsive nano-delivery carriers facilitated them to achieve more accurate tumor targeting and less toxicity, and finally improved antitumor ability of bioactive natural products.

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