A method for cylindrical explosion-containment vessels was presented, which used symmetrical implosion loading cooperating with the vessels to control the out-explosion loading, increasing the anti-explosion ability of explosion-containment vessels. In this study, theoretical analysis was developed first and response of cylindrical vessels loaded with implosion and out-explosion was discussed. Approximate expressions for final circumferential strain were obtained. Comparison between the theoretical calculations and the numerical simulations showed that the proposed method could effectively reduce the plastic strain of cylindrical explosion-containment vessels. The theoretical analysis introduced in this study can provide reference for related research. In addition, problems such as spall and defense of shock wave need to be solved before the presented method could be carried out in practical application.