Nanochips for Mass Spectrometry and Applications in Biomedical Research

Abstract Mass spectrometry imaging (MSI) enables the visualization of molecular distributions on complex surfaces. It has been extensively used in the field of biomedical research to investigate healthy and diseased tissues. Most of the MSI studies are conducted in a 2D fashion where only a single slice of the full sample volume is investigated. However, biological processes occur within a tissue volume and would ideally be investigated as a whole to gain a more comprehensive understanding of the spatial and molecular complexity of biological samples such as tissues and cells. Mass spectrometry imaging has therefore been expanded to the 3D realm whereby molecular distributions within a 3D sample can be visualized. The benefit of investigating volumetric data has led to a quick rise in the application of single-sample 3D-MSI investigations. Several experimental and data analysis aspects need to be considered to perform successful 3D-MSI studies. In this review, we discuss these aspects as well as ongoing developments that enable 3D-MSI to be routinely applied to multi-sample studies.

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Advancements of Mass Spectrometry in Biomedical Research

10.1007/978-3-030-15950-4 ◽

2019 ◽

Keyword(s):

Mass Spectrometry ◽

Biomedical Research

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Liquid chromatography-mass spectrometry with ionspray and electrospray interfaces in pharmaceutical and biomedical research

Journal of Chromatography A ◽

10.1016/s0021-9673(01)88435-1 ◽

1991 ◽

Vol 554 (1-2) ◽

pp. 39-46 ◽

Cited By ~ 41

Author(s):

A.P. Bruins

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Biomedical Research ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry

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Mass Spectrometry and its Applications in Life Sciences

Australian Journal of Chemistry ◽

10.1071/ch13284 ◽

2013 ◽

Vol 66 (7) ◽

pp. 719 ◽

Cited By ~ 17

Author(s):

Costel C. Darie

Keyword(s):

Mass Spectrometry ◽

Clinical Significance ◽

Biomedical Research ◽

Life Sciences ◽

Research Front ◽

Potential Use

Deciphering the biological and clinical significance of the proteins is investigated by mass spectrometry in a relatively new field, named proteomics. Mass spectrometry is, however, also used in chemistry for many years. In this Research Front we try to show the potential use of mass spectrometry in chemical, environmental and biomedical research and also to illustrate the applications of mass spectrometry in proteomics.

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