scholarly journals Phosphomannose Isomerase Deficiency: a novel, potentially treatable CDG syndrome variant • 709

1998 ◽  
Vol 43 ◽  
pp. 123-123
Author(s):  
C Dionisi-Vici ◽  
A Bartuli ◽  
E Bertini ◽  
H Carchon ◽  
H Henry ◽  
...  
Keyword(s):  
Phosphomannose Isomerase ◽  
Cdg Syndrome

scholarly journals PHOSPHOMANNOSE ISOMERASE

1950 ◽  
Vol 186 (2) ◽  
pp. 753-761 ◽  
Author(s):  
Milton W. Slein
Keyword(s):  
Phosphomannose Isomerase

The Burkholderia cepacia bceA gene encodes a protein with phosphomannose isomerase and GDP-d-mannose pyrophosphorylase activities

2007 ◽  
Vol 353 (1) ◽  
pp. 200-206 ◽  
Author(s):  
Sílvia A. Sousa ◽  
Leonilde M. Moreira ◽  
Julia Wopperer ◽  
Leo Eberl ◽  
Isabel Sá-Correia ◽  
...  
Keyword(s):  
Burkholderia Cepacia ◽  
Phosphomannose Isomerase

scholarly journals The rare sugar d-tagatose protects plants from downy mildews and is a safe fungicidal agrochemical

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Susumu Mochizuki ◽  
Takeshi Fukumoto ◽  
Toshiaki Ohara ◽  
Kouhei Ohtani ◽  
Akihide Yoshihara ◽  
...  
Keyword(s):  
Plant Diseases ◽  
Structural Development ◽  
Phosphomannose Isomerase ◽  
Inhibitory Effects ◽  
Food Ingredient ◽  
Rare Sugar ◽  
Initial Infection ◽  
Downy Mildews ◽  
Wide Range ◽  
Mannose Metabolism

AbstractThe rare sugar d-tagatose is a safe natural product used as a commercial food ingredient. Here, we show that d-tagatose controls a wide range of plant diseases and focus on downy mildews to analyze its mode of action. It likely acts directly on the pathogen, rather than as a plant defense activator. Synthesis of mannan and related products of d-mannose metabolism are essential for development of fungi and oomycetes; d-tagatose inhibits the first step of mannose metabolism, the phosphorylation of d-fructose to d-fructose 6-phosphate by fructokinase, and also produces d-tagatose 6-phosphate. d-Tagatose 6-phosphate sequentially inhibits phosphomannose isomerase, causing a reduction in d-glucose 6-phosphate and d-fructose 6-phosphate, common substrates for glycolysis, and in d-mannose 6-phosphate, needed to synthesize mannan and related products. These chain-inhibitory effects on metabolic steps are significant enough to block initial infection and structural development needed for reproduction such as conidiophore and conidiospore formation of downy mildew.

scholarly journals A novel Saccharomyces cerevisiae secretory mutant possesses a thermolabile phosphomannose isomerase.

1991 ◽  
Vol 173 (6) ◽  
pp. 2006-2010 ◽  
Author(s):  
M A Payton ◽  
M Rheinnecker ◽  
L S Klig ◽  
M DeTiani ◽  
E Bowden
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Phosphomannose Isomerase
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