scholarly journals Role of Cytochrome P-450 (CYP) as a Source of Catalytic Iron in Puromycin Aminonucleoside (PAN) Induced Animal Model of Minimal Change Nephrotic Syndrome (MCNS)

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 334A-334A
Author(s):  
Hua Liu ◽  
Sudhir V Shah ◽  
Radhakrishna Baliga
Keyword(s):  
Animal Model ◽  
Nephrotic Syndrome ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Puromycin Aminonucleoside ◽  
Cytochrome P 450

scholarly journals Role of ‘catalytic’ iron in an animal model of minimal change nephrotic syndrome

1996 ◽  
Vol 49 (2) ◽  
pp. 370-373 ◽  
Author(s):  
Norishi Ueda ◽  
Radhakrishna Baliga ◽  
Sudhir V. Shah
Keyword(s):  
Animal Model ◽  
Nephrotic Syndrome ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change

Cytochrome P-450 as a source of catalytic iron in minimal change nephrotic syndrome in rats

2001 ◽  
Vol 280 (1) ◽  
pp. F88-F94 ◽  
Author(s):  
Hua Liu ◽  
Sudhir V. Shah ◽  
Radhakrishna Baliga
Keyword(s):  
Nephrotic Syndrome ◽  
In Vitro Study ◽  
Minimal Change Nephrotic Syndrome ◽  
Significant Loss ◽  
Minimal Change ◽  
Puromycin Aminonucleoside ◽  
Glomerular Epithelial Cells ◽  
Cytochrome P 450 ◽  
Cyp Inhibitors

We have recently demonstrated an important pathogenic role for glomerular catalytic iron in the puromycin aminonucleoside (PAN) induced minimal change nephrotic syndrome (MCNS). The source of this iron capable of catalyzing free radical reactions is not known. We examined the role of cytochrome P-450 (CYP) as a source of catalytic iron in a model MCNS induced by single injection of PAN to rats. Treatment of PAN resulted in a marked increase in the catalytic iron associated with significant loss of glomerular CYP content. Administration of CYP inhibitors significantly prevented the injury-induced loss of CYP content and the increase in the catalytic iron in the glomeruli accompanied by a marked decrease in proteinuria. In an in vitro study utilizing glomerular epithelial cells (GEC), CYP inhibitors also markedly prevented the PAN-induced increase in the catalytic iron and hydroxyl radical formation accompanied by significant protection against PAN-induced cytotoxicity. Taken together our data indicate that the CYP, a group of heme protein, may serve as a significant source of this catalytic iron.

scholarly journals Role of basophils in the pathogenesis of minimal change nephrotic syndrome: A literature review

2014 ◽  
Vol 8 (4) ◽  
pp. 1027-1031 ◽  
Author(s):  
QINGJUN PAN ◽  
JING WU ◽  
JINGLI TAO ◽  
YANWEN CHEN ◽  
LU LI ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Literature Review ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change
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