scholarly journals Ophthalmic drug design based on the metabolic activity of the eye: Soft drugs and chemical delivery systems

2005 ◽  
Vol 7 (4) ◽  
pp. E820-E833 ◽  
Author(s):  
Nicholas Bodor ◽  
Peter Buchwald
Keyword(s):  
Drug Design ◽  
Metabolic Activity ◽  
Delivery Systems ◽  
Ophthalmic Drug ◽  
Soft Drugs ◽  
Chemical Delivery Systems

scholarly journals Chemical delivery systems and soft drugs: Retrometabolic approaches of drug design

2014 ◽  
Vol 22 (4) ◽  
pp. 290-302 ◽  
Author(s):  
Yashumati Ratan Bhardwaj ◽  
Ashutosh Pareek ◽  
Vivek Jain ◽  
Dharma Kishore
Keyword(s):  
Drug Design ◽  
Delivery Systems ◽  
Soft Drugs ◽  
Chemical Delivery Systems

Retrometabolic drug design: Principles and recent developments

2008 ◽  
Vol 80 (8) ◽  
pp. 1669-1682 ◽  
Author(s):  
Nicholas Bodor ◽  
Peter Buchwald
Keyword(s):  
Drug Design ◽  
Targeted Delivery ◽  
Active Drug ◽  
Therapeutic Index ◽  
Brain Targeting ◽  
Special Focus ◽  
Structure Activity ◽  
Recent Developments ◽  
Soft Drugs ◽  
Chemical Delivery Systems

Retrometabolic drug design incorporates two major systematic approaches: the design of soft drugs (SDs) and of chemical delivery systems (CDSs). Both aim to design new, safe drugs with an improved therapeutic index by integrating structure-activity and -metabolism relationships; however, they achieve it by different means: whereas SDs are new, active therapeutic agents that undergo predictable metabolism to inactive metabolites after exerting their desired therapeutic effect, CDSs are biologically inert molecules that provide enhanced and targeted delivery of an active drug to a particular organ or site through a designed sequential metabolism that involves several steps. General principles and recent developments are briefly reviewed with various illustrative examples from different therapeutic areas with special focus on soft corticosteroids and on brain targeting.

DRUG TARGETING BY RETROMETABOLIC DESIGN: SOFT DRUGS AND CHEMICAL DELIVERY SYSTEMS

2001 ◽  
Vol 21 (2-3) ◽  
pp. 287-310 ◽  
Author(s):  
Nicholas Bodor ◽  
Peter Buchwald
Keyword(s):  
Drug Targeting ◽  
Delivery Systems ◽  
Soft Drugs ◽  
Chemical Delivery Systems

Immunostimulant Properties of Chemical Delivery Systems in Vaccine Development

2015 ◽  
Vol 12 (4) ◽  
pp. 360-368 ◽  
Author(s):  
Sahar Hosseinzadeh ◽  
Azam Bolhassani
Keyword(s):  
Vaccine Development ◽  
Delivery Systems ◽  
Chemical Delivery Systems

scholarly journals Recent Advances in pH- or/and Photo-Responsive Nanovehicles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 725
Author(s):  
Yuseon Shin ◽  
Patihul Husni ◽  
Kioh Kang ◽  
Dayoon Lee ◽  
Sehwa Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Design ◽  
Solid Tumors ◽  
Tumor Targeting ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Controlled Delivery ◽  
Efficacy And Safety ◽  
Stimulus Responsive ◽  
External Signals

The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.

scholarly journals Ophthalmic Drug Delivery Systems for the Treatment of Retinal Diseases: Basic Research to Clinical Applications

2010 ◽  
Vol 51 (11) ◽  
pp. 5403 ◽  
Author(s):  
Henry F. Edelhauser ◽  
Cheryl L. Rowe-Rendleman ◽  
Michael R. Robinson ◽  
Daniel G. Dawson ◽  
Gerald J. Chader ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Basic Research ◽  
Delivery Systems ◽  
Clinical Applications ◽  
Retinal Diseases ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug

Recent Developments in Ophthalmic Drug Delivery Systems for Therapy of Both Anterior and Posterior Segment Diseases

2018 ◽  
Vol 24 ◽  
pp. 54-61 ◽  
Author(s):  
Hao Chen ◽  
Yingying Jin ◽  
Lin Sun ◽  
Xi Li ◽  
Kaihui Nan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Posterior Segment ◽  
Ophthalmic Drug Delivery ◽  
Recent Developments ◽  
Ophthalmic Drug

Chemical Delivery Systems

1991 ◽  
pp. 231-284 ◽  
Author(s):  
N. Bodor ◽  
M. E. Brewster
Keyword(s):  
Delivery Systems ◽  
Chemical Delivery Systems
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