scholarly journals In vitro and in vivo evaluation of single-unit commercial conventional tablet and sustained-release capsules compared with multiple-unit polystyrene microparticle dosage forms of ibuprofen

2006 ◽  
Vol 7 (3) ◽  
Author(s):  
Shunmugaperumal Tamilvanan ◽  
Biswanath Sa
Keyword(s):  
Sustained Release ◽  
Single Unit ◽  
Dosage Forms ◽  
In Vivo Evaluation ◽  
Conventional Tablet ◽  
Multiple Unit

In vitro and in vivo evaluation of a sustained-release once-a-day formulation of the novel antihypertensive drug MT-1207

2021 ◽  
Vol 26 (3) ◽  
pp. 349-361
Author(s):  
Napoleon-Nikolaos Vrettos ◽  
Peng Wang ◽  
Yan Zhou ◽  
Clive J. Roberts ◽  
Jinyi Xu ◽  
...  
Keyword(s):  
Sustained Release ◽  
Antihypertensive Drug ◽  
The Novel ◽  
In Vivo Evaluation

scholarly journals Design and evaluation of a novel floating osmotic pump system

2009 ◽  
Vol 12 (1) ◽  
pp. 129 ◽  
Author(s):  
Zhihong Zhang ◽  
Bo Peng ◽  
Xinggang Yang ◽  
Chao Wang ◽  
Guangmei Sun ◽  
...  
Keyword(s):  
Drug Release ◽  
Oral Administration ◽  
In Vitro Release ◽  
Osmotic Pump ◽  
Matrix Tablets ◽  
In Vivo Evaluation ◽  
Pump System ◽  
Conventional Tablet

PURPOSE. Find a novel delivery system for oral administration of drugs that have absorption window in the upper part of gastrointestinal (GI) track. METHODS. Dipyridamole was chosen as the model drug. A novel system, which combined the osmotic pump controlled release system and the floating system, was designed; matrix tablets (MT) were prepared for compares. The effects of pH, temperature and hydrodynamic conditions on drug release and the floating behavior of floating osmotic pump system (FOP) were investigated. In vivo evaluation was performed by a three-crossover study in six Beagle dogs relative to the conventional tablet (CT). Cumulative percent input in vivo was compared with that of in vitro release profiles. RESULTS. Floating behavior of FOP, drug releases from FOP and MT were sensitive to pH of dissolution media but not sensitive to temperature; the release of dipyridamole from MT was influenced by stirring rate while drug release from FOP was not. AUC of FOP was larger than MT and CT. The linear correlations between fraction absorbed in vivo and fraction dissolved in vitro was established for FOP-a true zero-order release formula, whereas only a nonlinear correlation was obtained for MT. CONCLUTIONS. FOP could be a novel way for the oral administration for drugs like dipyridamole.

SUSTAINED RELEASE HYDROPHILIC MATRICES BASED ON XANTHAN GUM AND HYDROXYPROPYL METHYLCELLULOSE: DEVELOPMENT, OPTIMIZATION, IN VITRO AND IN VIVO EVALUATION

2010 ◽  
Vol 2 ◽  
pp. 89-103
Author(s):  
Muhammad Sajid Hamid Akash . ◽  
Ikram Ullah Khan . ◽  
Syed Nisar Hussain Shah . ◽  
Sajid Asghar . ◽  
Asif massud . ◽  
...  
Keyword(s):  
Sustained Release ◽  
Xanthan Gum ◽  
Hydroxypropyl Methylcellulose ◽  
In Vivo Evaluation ◽  
Hydrophilic Matrices

Taro-corms mucilage-alginate microspheres for the sustained release of pregabalin: In vitro & in vivo evaluation

2019 ◽  
Vol 139 ◽  
pp. 1191-1202 ◽  
Author(s):  
Shazia Akram Ghumman ◽  
Sajid Bashir ◽  
Sobia Noreen ◽  
Abdul Muqeet Khan ◽  
Muhammad Zubair Malik
Keyword(s):  
Sustained Release ◽  
In Vivo Evaluation

scholarly journals Design and comparative in-vitro and in-vivo evaluation of starch-acrylate graft copolymer based salbutamol sulphate sustained release tablets

2015 ◽  
Vol 10 (3) ◽  
pp. 239-246 ◽  
Author(s):  
Pankaj Kumar ◽  
Ashok Laxmanrao Ganure ◽  
Bharat Bhushan Subudhi ◽  
Shubhanjali Shukla ◽  
Pooja Upadhyay
Keyword(s):  
Sustained Release ◽  
Graft Copolymer ◽  
In Vivo Evaluation ◽  
Salbutamol Sulphate ◽  
Sustained Release Tablets
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