scholarly journals Prediction of Solubility and Permeability Class Membership: Provisional BCS Classification of the World’s Top Oral Drugs

2009 ◽  
Vol 11 (4) ◽  
pp. 740-746 ◽  
Author(s):  
Arik Dahan ◽  
Jonathan M. Miller ◽  
Gordon L. Amidon
Keyword(s):  
2003 ◽  
Vol 46 (4) ◽  
pp. 558-570 ◽  
Author(s):  
Christel A. S. Bergström ◽  
Melissa Strafford ◽  
Lucia Lazorova ◽  
Alex Avdeef ◽  
Kristina Luthman ◽  
...  

Methodology ◽  
2018 ◽  
Vol 14 (2) ◽  
pp. 82-93
Author(s):  
Yi-Jhen Wu ◽  
Insu Paek

Abstract. When using the mixture Rasch model, the model identification constraints are either to set the equal means for all classes in the assumed normal ability distributions (equal ability mean constraint in short), or to set the sum of item difficulties to be zero for each class. In real data analysis, however, both constraints are not always sufficient to establish a common scale across latent classes unless some items are specified as anchor items in the estimation. If these two conventional constraint approaches recover the class membership as good as the anchor item constraint approach, the conventional constraint approaches may be considered useful for the purpose of class membership classification. This study investigated agreement on class membership between one conventional constraint (the equal ability mean) and the anchor item constraint approaches. Results showed high agreement between these two constraint approaches, indicating that the conventional constraint of the equal mean ability approach may be used to recover the latent class membership although item profiles are not correctly estimated across latent classes.


2013 ◽  
Vol 10 (12) ◽  
pp. 4739-4745 ◽  
Author(s):  
Chuan Chen ◽  
Michael G. Ma ◽  
Cody L. Fullenwider ◽  
Weichao G. Chen ◽  
Abu J. M. Sadeque

1970 ◽  
Vol 117 (541) ◽  
pp. 685-688 ◽  
Author(s):  
I. Pilowsky ◽  
M. D. McGrath

The classification of depressive illnesses continues to be a problematic and controversial issue (Kendell, 1968; Hope, 1969). The many statistical approaches applied to this complex question since Hamilton's original study (1960) have been reviewed by Kendell (1968). More recently, Pilowsky, Levine and Boulton (1969) have offered evidence (based on the application of information theory taxonomy to patients' questionnaire responses) which supports the validity of regarding ‘endogenous' depression as a clinical entity. Following on this study, Pilowsky and Boulton (1970) have developed a decision rule for the identification of depressive class members and have shown that class membership is related to the response to electroconvulsive therapy; patients in the ‘endogenous' Class B group having a better clinical outcome.


2020 ◽  
Vol 497 (2) ◽  
pp. 1391-1403
Author(s):  
Rachel A Smullen ◽  
Kathryn Volk

ABSTRACT In the outer Solar system, the Kuiper belt contains dynamical subpopulations sculpted by a combination of planet formation and migration and gravitational perturbations from the present-day giant planet configuration. The subdivision of observed Kuiper belt objects (KBOs) into different dynamical classes is based on their current orbital evolution in numerical integrations of their orbits. Here, we demonstrate that machine learning algorithms are a promising tool for reducing both the computational time and human effort required for this classification. Using a Gradient Boosting Classifier, a type of machine learning regression tree classifier trained on features derived from short numerical simulations, we sort observed KBOs into four broad, dynamically distinct populations – classical, resonant, detached, and scattering – with a >97 per cent accuracy for the testing set of 542 securely classified KBOs. Over 80 per cent of these objects have a >3σ probability of class membership, indicating that the machine learning method is classifying based on the fundamental dynamical features of each population. We also demonstrate how, by using computational savings over traditional methods, we can quickly derive a distribution of class membership by examining an ensemble of object clones drawn from the observational errors. We find two major reasons for misclassification: inherent ambiguity in the orbit of the object – for instance, an object that is on the edge of resonance – and a lack of representative examples in the training set. This work provides a promising avenue to explore for fast and accurate classification of the thousands of new KBOs expected to be found by surveys in the coming decade.


2007 ◽  
Vol 4 (4) ◽  
pp. 608-614 ◽  
Author(s):  
Yongsheng Yang ◽  
Patrick J. Faustino ◽  
Donna A. Volpe ◽  
Christopher D. Ellison ◽  
Robbe C. Lyon ◽  
...  

1966 ◽  
Vol 24 ◽  
pp. 21-23
Author(s):  
Y. Fujita

We have investigated the spectrograms (dispersion: 8Å/mm) in the photographic infrared region fromλ7500 toλ9000 of some carbon stars obtained by the coudé spectrograph of the 74-inch reflector attached to the Okayama Astrophysical Observatory. The names of the stars investigated are listed in Table 1.


Sign in / Sign up

Export Citation Format

Share Document