A Physiologically Based Pharmacokinetic Model of Mitoxantrone in Mice and Scale-up to Humans: a Semi-Mechanistic Model Incorporating DNA and Protein Binding

The AAPS Journal ◽

10.1208/s12248-012-9344-7 ◽

2012 ◽

Vol 14 (2) ◽

pp. 352-364 ◽

Author(s):

Guohua An ◽

Marilyn E. Morris

Keyword(s):

Protein Binding ◽

Pharmacokinetic Model ◽

Mechanistic Model ◽

Scale Up ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Development and application of a physiologically based pharmacokinetic model for entrectinib in rats and scale-up to humans: Route-dependent gut wall metabolism

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2021.112520 ◽

2022 ◽

Vol 146 ◽

pp. 112520

Author(s):

Seong-Wook Seo ◽

Dong-Gyun Han ◽

Eugene Choi ◽

Taeuk Park ◽

Jong Hyuk Byun ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Scale Up ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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A Physiologically Based Pharmacokinetic Model of Zidovudine (AZT) in the Mouse: Model Development and Scale-Up to Humans

Journal of Pharmaceutical Sciences ◽

10.1021/js970243y ◽

1997 ◽

Vol 86 (11) ◽

pp. 1223-1228 ◽

Author(s):

Hsiao-Hui Chow

Keyword(s):

Mouse Model ◽

Pharmacokinetic Model ◽

Scale Up ◽

Model Development ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Use of a Physiologically Based Pharmacokinetic Model to Study the Time to Reach Brain Equilibrium: An Experimental Analysis of the Role of Blood-Brain Barrier Permeability, Plasma Protein Binding, and Brain Tissue Binding

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.104.079319 ◽

2005 ◽

Vol 313 (3) ◽

pp. 1254-1262 ◽

Author(s):

Xingrong Liu ◽

Bill J. Smith ◽

Cuiping Chen ◽

Ernesto Callegari ◽

Stacey L. Becker ◽

...

Keyword(s):

Protein Binding ◽

Brain Tissue ◽

Experimental Analysis ◽

Pharmacokinetic Model ◽

Tissue Binding ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Brain Barrier Permeability ◽

Physiologically Based

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A Whole-Body Physiologically Based Pharmacokinetic Model of Gefitinib in Mice and Scale-Up to Humans

The AAPS Journal ◽

10.1208/s12248-015-9836-3 ◽

2015 ◽

Vol 18 (1) ◽

pp. 228-238 ◽

Author(s):

Youwei Bi ◽

Jiexin Deng ◽

Daryl J. Murry ◽

Guohua An

Keyword(s):

Pharmacokinetic Model ◽

Scale Up ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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A Physiologically Based Pharmacokinetic Model of Vismodegib: Deconvoluting the Impact of Saturable Plasma Protein Binding, pH-Dependent Solubility and Nonsink Permeation

The AAPS Journal ◽

10.1208/s12248-020-00503-7 ◽

2020 ◽

Vol 22 (5) ◽

Author(s):

Michael J. Dolton ◽

Po-Chang Chiang ◽

Fang Ma ◽

Jin Y. Jin ◽

Yuan Chen

Keyword(s):

Protein Binding ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Ph Dependent ◽

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Scale-up of a physiologically-based pharmacokinetic model to predict the disposition of monoclonal antibodies in monkeys

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-015-9444-y ◽

2015 ◽

Vol 42 (5) ◽

pp. 527-540 ◽

Author(s):

Patrick M. Glassman ◽

Yang Chen ◽

Joseph P. Balthasar

Keyword(s):

Monoclonal Antibodies ◽

Pharmacokinetic Model ◽

Scale Up ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Preliminary Physiologically Based Pharmacokinetic Model for Cocaine in the Rat: Model Development and Scale-Up to Humans

Journal of Pharmaceutical Sciences ◽

10.1021/js950437i ◽

1996 ◽

Vol 85 (8) ◽

pp. 878-883 ◽

Author(s):

Peter L. Bonatex ◽

Alan Swann ◽

Peter B. Silverman

Keyword(s):

Rat Model ◽

Pharmacokinetic Model ◽

Scale Up ◽

Model Development ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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A physiologically based pharmacokinetic model linking plasma protein binding interactions with drug disposition

Research in Veterinary Science ◽

10.1016/j.rvsc.2008.07.003 ◽

2009 ◽

Vol 86 (2) ◽

pp. 293-301 ◽

Author(s):

J.L. Buur ◽

R.E. Baynes ◽

G.W. Smith ◽

J.E. Riviere

Keyword(s):

Protein Binding ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Pharmacokinetic Model ◽

Drug Disposition ◽

Physiologically Based Pharmacokinetic Model ◽

Binding Interactions ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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A physiologically based pharmacokinetic model to predict the pharmacokinetics of highly protein-bound drugs and the impact of errors in plasma protein binding

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.1996 ◽

2016 ◽

Vol 37 (3) ◽

pp. 123-141 ◽

Author(s):

Min Ye ◽

Swati Nagar ◽

Ken Korzekwa

Keyword(s):

Protein Binding ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

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Physiologically based pharmacokinetic model development for trazodone: application to paediatric dose projection

10.26226/morressier.5971be87d462b80290b534f2 ◽

2017 ◽

Author(s):

F. Calisti

Keyword(s):

Pharmacokinetic Model ◽

Model Development ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Paediatric Dose

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