Innovative Design and Analysis for PK/PD Biosimilar Bridging Studies with Multiple References

2021 ◽  
Vol 24 (1) ◽  
Author(s):  
Fuyu Song ◽  
Xin Zheng ◽  
Yujia Wang ◽  
Shein-Chung Chow ◽  
Hongqiang Sun
2020 ◽  
Vol 102 (2) ◽  
pp. 143-157
Author(s):  
Raymond Richard Neutra

The Lovell Health House (1927–1929) by Richard Neutra for Dr. Phillip Lovell and his wife, Leah Lovell, was a turning point in modern architecture. The house not only carried out Phillip Lovell’s principles of healthy living, it also incorporated a school conducted along the progressive educational theories embraced by Leah Lovell. This article identifies the educational features in Neutra’s plan. Interviews with one of the last remaining students of the school shed light on the students and faculty and how the design served the school’s curriculum. Neutra’s innovative design accommodating the progressive educational program at the Lovell Health House belongs in any discussion of the later school designs for which he won lasting acclaim.


2010 ◽  
Vol 6 (3) ◽  
pp. 66 ◽  
Author(s):  
Carlo Pappone ◽  
Luigi Giannelli ◽  
Vincenzo Santinelli ◽  
◽  
◽  
...  

Innovative technologies are being developed to make current ablation procedures safer and easier. Sometimes conventional ablation catheters cannot easily adapt to anatomical targets, making radiofrequency applications challenging, time consuming or even ineffective. The Cool Flex is a novel, flexible and fully-irrigated tip catheter with an innovative design and various angular orientations to better adapt the ablation tip to the surrounding tissue. Here, peliminary experience with this new ablation catheter is reported in the treatment of different tachyarrhythmias, including slow and accessory pathway ablation, cavotricuspid isthmus-dependent atrial flutter and atrial fibrillation. One or two radiofreqency applications may be sufficient to eliminate the arrhythmogenic substrate in most patients without complications.


PCI Journal ◽  
2001 ◽  
Vol 46 (1) ◽  
pp. 14-21
Author(s):  
Bruno Elias Ramos ◽  
John Colao ◽  
Paul Martinez ◽  
Peter G. Trolani ◽  
Ted Wolfstahl

2014 ◽  
Vol 5 (2) ◽  
pp. 662-671
Author(s):  
Dr. Mohan Babu. G. N. ◽  
Sushravya. G. M.

Most educational models that prescribe teaching and training methods to groom school children into innovators fail to take a deeper view of engineering design methodology. Yet others tend to ignore the importance of human values which must be an integral part of any innovative design process.  In this paper, We would first disaggregate design capabilities into its constituent capabilities, namely, exploring, creating and converging capabilities, which we need to master to produce better products and services, and then show how the cognitive and affective skills proposed by Benjamin Bloom, and Anderson and Krathwohl in their educational models can directly and significantly contribute to these constituent capabilities. With an improved understanding of the eco-system needed for better design solutions, we suggest that the present education systems, especially in developing countries, be critically reviewed and reoriented from the perspective of producing quality innovative designers, regardless of the problem area.  


2019 ◽  
Vol 7 ◽  
pp. 149-157
Author(s):  
I.N. Klementyeva ◽  
◽  
D.A. Kuziev ◽  
Keyword(s):  

2013 ◽  
Author(s):  
Tao Li ◽  
Shan Gao ◽  
Qiang Chen ◽  
Yiliang Li ◽  
Weiye Han ◽  
...  
Keyword(s):  

2018 ◽  
Vol 56 (9) ◽  
pp. 801-808
Author(s):  
K. Wada ◽  
H. Sakurai ◽  
K. Takimoto ◽  
S. Yamamoto

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