Kinetic Model Development for Accelerated Stability Studies

2016 ◽  
Vol 18 (4) ◽  
pp. 1158-1176 ◽  
Author(s):  
Don Clancy ◽  
Neil Hodnett ◽  
Rachel Orr ◽  
Martin Owen ◽  
John Peterson
2017 ◽  
Vol 29 (1) ◽  
pp. 94-98 ◽  
Author(s):  
Santosh R. Butle ◽  
Padmanabh B. Deshpande

2021 ◽  
Vol 18 ◽  
Author(s):  
Komal Parmar ◽  
Jay Shah

Purpose: Present investigation was aimed to fabricate nanocrystal of exemestane, an anticancer drug with poor dissolution properties and oral bioavailability. Methods: Influence of various process parameters on the formulation of exemestane nanosuspension using media milling technique were investigated in the trial batches. Box-Behnken design was applied with independent variables identified in the preliminary studies, viz. X1-Milling time, X2-Amount of stabilizer and X3-Amount of milling agent. In vitro dissolution and in vivo studies were carried out. Solid state characterization (PXRD, SEM, and DSC) studies demonstrated physical changes in drug due to nano-crystallization. Accelerated stability studies of optimized formulation were carried out. Results: Individual process attributes exhibited significant effect on the average particle size of exemestane nanosuspension. Dissolution studies revealed enhancement in drug release rate as compared to pure exemestane powder. The in vivo pharmacokinetic parameters of exemestane nanosuspension showed significant improvement in Cmax and AUC0-t, about 283.85% and 271.63% respectively suggesting amelioration in oral bioavailability by 2.7-fold as compared to pure exemestane. Accelerated stability studies of the optimized formulation suggested stability of the nanocrystals for at least sixmonth period. Conclusion: Nanocrystals prepared by media milling technique were successful in improving the poor dissolution properties and oral bioavailability of exemestane.


2018 ◽  
Vol 78 (11) ◽  
pp. 2279-2287 ◽  
Author(s):  
Qianyi Zhang ◽  
Mohamed Gaafar ◽  
Evan G. R. Davies ◽  
James R. Bolton ◽  
Yang Liu

Abstract Monochloramine (NH2Cl), as the dominant disinfectant in drinking water chloramination, can provide long-term disinfection in distribution systems. However, NH2Cl can also be discharged into storm sewer systems and cause stormwater contamination through outdoor tap water uses. In storm sewer systems, NH2Cl dissipation can occur by three pathways: (i) auto-decomposition, (ii) chemical reaction with stormwater components, and (iii) biological dissipation. In this research, a field NH2Cl dissipation test was conducted with continuous tap water discharge into a storm sewer. The results showed a fast decrease of NH2Cl concentration from the discharge point to the sampling point at the beginning of the discharge period, while the rate of decrease decreased as time passed. Based on the various pathways involved in NH2Cl decay and the field testing results, a kinetic model was developed. To describe the variation of the NH2Cl dissipation rates during the field testing, a time coefficient fT was introduced, and the relationship between fT and time was determined. After calibration through the fT coefficient, the kinetic model described the field NH2Cl dissipation process well. The model developed in this research can assist in the regulation of tap water outdoor discharge and contribute to the protection of the aquatic environment.


Author(s):  
Ibrahim Javed ◽  
Saeed ur Rasheed Nazir ◽  
Nazar Muhammad Ranjha ◽  
Asif Massud ◽  
Liaqat Hussain

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