Nanolipid Gel of an Antimycotic Drug for Treating Vulvovaginal Candidiasis—Development and Evaluation

Although considerable information has accumulated in the last decade regarding rates of both vaginal colonization and vulvovaginal candidiasis (VVC) in HIV-positive women, gaps in our knowledge remain, particularly with regard to pathophysiology of clinical disease. Unfortunately, early and possibly premature conclusions were reached in the late 1980s which resulted in the widespread dissemination of information indicating that recurrent VVC (RVVC) was a manifestation of HIV infection and that women with RVVC should be tested for HIV. Unfortunately, subsequent data from cohort studies involving HIV-positive women failed to determine attack rates of symptomatic Candida vaginitis requiring therapy. Recent studies indicate that Candida vaginitis, even if more frequent in HIV infected women, is clinically similar to that experienced in HIV-negative women and does not appear to be of increased clinical severity. VVC in HIV-positive women can be treated by conventional methods including the use of maintenance suppressive antifungal therapy and most importantly RVVC in women is not in itself a sentinel of HIV infection. Ongoing concerns include vaginal acquisition of non- albicans Candida species and the development of antimycotic drug resistance in C. albicans vaginal isolates.

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Effect of Lactobacillus in Preventing Post-antibiotic Vulvovaginal Candidiasis: A Randomised Controlled Trial

Yearbook of Pediatrics ◽

10.1016/s0084-3954(07)70126-4 ◽

2006 ◽

Vol 2006 ◽

pp. 189-190

Author(s):

J.A. Stockman

Keyword(s):

Randomised Controlled Trial ◽

Controlled Trial ◽

Vulvovaginal Candidiasis ◽

Randomised Controlled

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Laboratory evaluation of the etiology of pathological vaginal dischurge

HEALTH OF WOMAN ◽

10.15574/hw.2019.140.64 ◽

2019 ◽

pp. 64-68

Author(s):

O.A. Burka ◽

◽

T.M. Tutchenko ◽

Keyword(s):

Bacterial Vaginosis ◽

Crucial Role ◽

Inflammatory Process ◽

Vaginal Discharge ◽

Vulvovaginal Candidiasis ◽

Diagnostic Methods ◽

Laboratory Evaluation ◽

Aerobic Vaginitis ◽

Laboratory Confirmation ◽

Vaginal Secretions

Pathological vaginal discharge is one of the most common complaints in women of all ages. Today, gynecologists are increasingly faced with a problem when, in the absence of laboratory confirmation of vulvovaginal candidiasis, bacterial vaginosis and STIs, women complain of discomfort caused by vaginal secretions. Causes of pathological vaginal discharge can be infectious and non-infectious processes and their combinations. The article analyzes the causes of the difficulties of diagnosing the of pathological vaginal discharge ethiology, demonstrates how the application of adequate volume of modern laboratory diagnostic methods in combination with understanding the multifaceted components of the inflammatory process plays crucial role in finding out the etiology of pathological vaginal secretions and the choice of optimal therapeutic tactics. Key words: pathological vaginal dischurge, vaginal microbiota, vulvovaginal candidiasis, bacterial vaginosis, aerobic vaginitis, cytolytic vaginosis.

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