6. Patient with Nontoxic Multinodular Goiter

2012 ◽  
pp. 62-78
Author(s):  
Rebecca S. Bahn ◽  
M. Regina Castro
Keyword(s):  
Multinodular Goiter

Abstract #1010: Uveal Melanoma Masquerading as A Nontoxic Multinodular Goiter

2015 ◽  
Vol 21 ◽  
pp. 194-195
Author(s):  
Rokshana Thanadar ◽  
Uzma Siddiqui ◽  
Marie Lithgow ◽  
Runhua Hou
Keyword(s):  
Uveal Melanoma ◽  
Multinodular Goiter

Thyroid arterial embolization for the treatment of large multinodular goiter and hyperthyroidism

2018 ◽  
Author(s):  
Gul Ozen Oz ◽  
Soner Cander ◽  
Pinar Sisman ◽  
Aytul Cosar ◽  
Canan Ersoy ◽  
...  
Keyword(s):  
Multinodular Goiter ◽  
Arterial Embolization

Rare association of primary hyperparathyroidism and toxic multinodular goiter

2018 ◽  
Author(s):  
Hamza Elfekih ◽  
Mouna Elleuch ◽  
Dorra Ghorbel ◽  
Faten Hadjkacem ◽  
Mouna Ammar ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Multinodular Goiter ◽  
Rare Association ◽  
Toxic Multinodular Goiter

Alteration of Trace Elements in Multinodular Goiter, Thyroid Adenoma, and Thyroid Cancer

2021 ◽  
Author(s):  
Aleksandar Stojsavljević ◽  
Branislav Rovčanin ◽  
Jovana Jagodić ◽  
Đurđa Krstić ◽  
Ivan Paunović ◽  
...  
Keyword(s):  
Trace Elements ◽  
Thyroid Cancer ◽  
Multinodular Goiter ◽  
Thyroid Adenoma

scholarly journals Gene expression profile in functioning and non-functioning nodules of autonomous multinodular goiter from an area of iodine deficiency: unexpected common characteristics between the two entities

2021 ◽  
Author(s):  
P. Agretti ◽  
G. De Marco ◽  
E. Ferrarini ◽  
C. Di Cosmo ◽  
L. Montanelli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Multinodular Goiter ◽  
Kinase Inhibitor ◽  
Wnt Signaling Pathway ◽  
Iodine Intake ◽  
Healthy Tissue ◽  
Specific Gene ◽  
Complement Components

Abstract Purpose Toxic multinodular goiter is a heterogeneous disease associated with hyperthyroidism frequently detected in areas with deficient iodine intake, and functioning and non-functioning nodules, characterized by increased proliferation but opposite functional activity, may coexist in the same gland. To understand the distinct molecular pathology of each entity present in the same gland, the gene expression profile was evaluated by using the Affymetrix technology. Methods Total RNA was extracted from nodular and healthy tissues of two patients and double-strand cDNA was synthesized. Biotinylated cRNA was obtained and, after chemical fragmentation, was hybridized on U133A and B arrays. Each array was stained and the acquired images were analyzed to obtain the expression levels of the transcripts. Both functioning and non-functioning nodules were compared versus healthy tissue of the corresponding patient. Results About 16% of genes were modulated in functioning nodules, while in non-functioning nodules only 9% of genes were modulated with respect to the healthy tissue. In functioning nodules of both patients and up-regulation of cyclin D1 and cyclin-dependent kinase inhibitor 1 was observed, suggesting the presence of a possible feedback control of proliferation. Complement components C1s, C7 and C3 were down-regulated in both types of nodules, suggesting a silencing of the innate immune response. Cellular fibronectin precursor was up-regulated in both functioning nodules suggesting a possible increase of endothelial cells. Finally, Frizzled-1 was down-regulated only in functioning nodules, suggesting a role of Wnt signaling pathway in the proliferation and differentiation of these tumors. None of the thyroid-specific gene was deregulated in microarray analysis. Conclusion In conclusion, the main finding from our data is a similar modulation for both kinds of nodules in genes possibly implicated in thyroid growth.

Free triiodothyronine toxicosis in a patient with multinodular goiter

1990 ◽  
Vol 88 (6) ◽  
pp. 689-692 ◽  
Author(s):  
Richard J. Simons ◽  
Andrea Manni ◽  
Shih-Lieh Fang ◽  
Lewis Braverman
Keyword(s):  
Multinodular Goiter ◽  
Free Triiodothyronine

Lack of Reported Mutations in a Japanese Case of Toxic Multinodular Goiter

ORL ◽  
2002 ◽  
Vol 64 (4) ◽  
pp. 275-277
Author(s):  
Masakazu Hanamitsu ◽  
Eiji Takeuchi ◽  
Tsuyoshi Kitanishi ◽  
Hironori Sakurai ◽  
Hiroshi Tanaka ◽  
...  
Keyword(s):  
Multinodular Goiter ◽  
Japanese Case ◽  
Toxic Multinodular Goiter

Pathogenesis of multinodular goiter in elderly XB130 deficient mice: alteration of thyroperoxidase affinity with iodide and hydrogen peroxide

Thyroid ◽  
2021 ◽  
Author(s):  
Hae-Ra Cho ◽  
Junichi Sugihara ◽  
Hiroki Shimizu ◽  
Yun-Yan Xiang ◽  
Xiao-Hui Bai ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Multinodular Goiter ◽  
Deficient Mice
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