Developmental hormonal profiles accompanying the neonatal hypothyroidism-induced increase in adult testicular size and sperm production in the rat

Endocrinology ◽  
1992 ◽  
Vol 131 (2) ◽  
pp. 559-565 ◽  
Author(s):  
J. D. Kirby
Keyword(s):  
Sperm Production ◽  
Neonatal Hypothyroidism ◽  
Hormonal Profiles ◽  
Testicular Size

Developmental hormonal profiles accompanying the neonatal hypothyroidism-induced increase in adult testicular size and sperm production in the rat.

Endocrinology ◽  
1992 ◽  
Vol 131 (2) ◽  
pp. 559-565
Author(s):  
J D Kirby ◽  
A E Jetton ◽  
P S Cooke ◽  
R A Hess ◽  
D Bunick ◽  
...  
Keyword(s):  
Sperm Production ◽  
Neonatal Hypothyroidism ◽  
Hormonal Profiles ◽  
Testicular Size

scholarly journals Developmental Hormonal Profiles in rdw Rats with Congenital Hypothyroidism Accompanying Increased Testicular Size and Infertility in Adulthood

2004 ◽  
Vol 50 (6) ◽  
pp. 675-684 ◽  
Author(s):  
Motoaki UMEZU ◽  
Satoshi KAGABU ◽  
Jiany Y. JIANG ◽  
Sueo NIIMURA ◽  
Eimei SATO
Keyword(s):  
Congenital Hypothyroidism ◽  
Hormonal Profiles ◽  
Testicular Size

Ultrasonic testicular size of 24,440 adult Vietnamese men and the correlation with age and hormonal profiles

Andrologia ◽  
2021 ◽  
Author(s):  
Bac Nguyen Hoai ◽  
Long Hoang ◽  
Duc Tran ◽  
Thang Nguyen Cao ◽  
Luu Doan Tien ◽  
...  
Keyword(s):  
Hormonal Profiles ◽  
Testicular Size

scholarly journals Sperm production, testicular size, serum gonadotropins and testosterone levels in Merino and Corriedale breeds

1999 ◽  
Vol 39 (5-6) ◽  
pp. 617-624 ◽  
Author(s):  
D. Fernandez-Abella ◽  
D. Becu-Villalobos ◽  
I. M. Lacau-Mengido ◽  
N. Villegas ◽  
O. Bentancur
Keyword(s):  
Sperm Production ◽  
Testosterone Levels ◽  
Testicular Size

scholarly journals Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production.

1995 ◽  
Vol 103 (12) ◽  
pp. 1136-1143 ◽  
Author(s):  
R M Sharpe ◽  
J S Fisher ◽  
M M Millar ◽  
S Jobling ◽  
J P Sumpter
Keyword(s):  
Sperm Production ◽  
Lactational Exposure ◽  
Testicular Size

Increased Sperm Production in Adult Rats After Transient Neonatal Hypothyroidism*

Endocrinology ◽  
1991 ◽  
Vol 129 (1) ◽  
pp. 244-248 ◽  
Author(s):  
PAUL S. COOKE ◽  
REX A. HESS ◽  
JOHN PORCELLI ◽  
ESMAIL MEISAMI
Keyword(s):  
Sperm Production ◽  
Adult Rats ◽  
Neonatal Hypothyroidism

Lupin and cowpea supplements for growth, wool production, and reproduction in rams

1995 ◽  
Vol 35 (4) ◽  
pp. 447 ◽  
Author(s):  
CC Pomares ◽  
DB Galloway ◽  
JHG Holmes ◽  
IJ Clarke ◽  
AJ Tilbrook
Keyword(s):  
Volume Concentration ◽  
Testicular Tissue ◽  
Grain Legume ◽  
Sperm Production ◽  
Cell Nuclei ◽  
Cross Sectional ◽  
Wool Growth ◽  
Condition Score ◽  
Testicular Size ◽  
Australian Merino

Lupins and cowpeas were fed at 0.0, 0.5, 1.0, and 2.0% liveweight (LW) to groups of 6 or 7 South Australian Merino rams for 11 weeks as supplements to a maintenance diet of grass hay. Productive and reproductive parameters were examined. Supplementation at all levels of either grain increased (P<0.001) LW, condition score, backfat thickness, and wool growth, with rams showing similar responses when given cowpeas and lupins. The weights of the pancreas of rams decreased (P<0.01) as the levels of supplementation increased. Semen characteristics (volume, concentration, motility, etc.) and response to freezing did not differ between the diets. Feeding either legume increased (P<0.001) testicular size, lupins giving a slightly greater response than cowpeas. Sperm production per g testicular tissue was not significantly altered. Increasing levels of either supplement increased (P<0.001) the weights of the seminal vesicles, more (P<0.01) so with lupins. The same effects occurred with the weight of epididymides except for rams fed cowpeas at the highest level. Histologically, the testes revealed an increase (P<0.001) in the number of round spermatogenic cell nuclei and the cross-sectional diameter of stage 8 tubules in rams after legume grain supplementation at 2.0% LW compared with controls. The response was higher in lupin-fed rams (P<0.05). Plasma luteinising hormone (LH) and follicle stimulating hormone (FSH) were measured in rams fed at maintenance or with lupins or cowpeas at 2.0% LW. Rams responded equally to all legumes. Concentrations of LH in peripheral blood increased (P<0.001) by 140% and FSH concentrations were elevated (P<0.01) 4-fold. Cowpeas, a tropical grain legume similar in nutrient composition to lupins, have similar potential when used as a supplement to improve productive and reproductive capabilities of Merino rams.

scholarly journals Neonatal hypothyroidism does not increase Sertoli cell proliferation in iNOS−/− mice

Reproduction ◽  
2017 ◽  
Vol 154 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Nathália L M Lara ◽  
Luiz R França
Keyword(s):  
Thyroid Hormones ◽  
Sertoli Cell ◽  
Leydig Cells ◽  
Testis Size ◽  
Additive Effects ◽  
Sperm Production ◽  
Wild Type ◽  
Neonatal Hypothyroidism ◽  
Laboratory Rodents ◽  
Daily Sperm Production

Sertoli cell (SC) proliferation in mice occurs until two weeks after birth and is mainly regulated by FSH and thyroid hormones. Previous studies have shown that transient neonatal hypothyroidism in laboratory rodents is able to extend SC mitotic activity, leading ultimately to higher testis size and daily sperm production (DSP) in adult animals. Moreover, we have shown that due to higher SC proliferation and lower germ cell apoptosis, iNOS deficiency in mice also results in higher testis size and DSP. Although the cell size was smaller, the Leydig cells (LCs) number per testis also significantly increased in iNOS−/−mice. Our aims in the present study were to investigate if the combination of neonatal hypothyroidism and iNOS deficiency promotes additive effects in SC number, testis size and DSP. Hypothyroidism was induced in wild-type (WT) and iNOS−/−mice using 6-propyl-2-thiouracil (PTU) through the mother’s drinking water from 0 to 20 days of age, and were sacrificed at adulthood. Our results showed that, in contrast to the WT mice in which testis size, DSP and SC numbers increased significantly by 20, 40 and 70% respectively, after PTU treatment, no additive effects were observed for these parameters in treated iNOS−/−mice, as well as for LC. No alterations were observed in spermatogenesis in any group evaluated. Although we still do not have an explanation for these intriguing findings, we are currently investigating whether thyroid hormones influence iNOS levels and/or counterbalance physiological effects of iNOS deficiency in testis function and spermatogenesis.

scholarly journals Prepubertal PTU treatment in rat increases Sertoli cell number and sperm production

Reproduction ◽  
2019 ◽  
Vol 158 (2) ◽  
pp. 201-211 ◽  
Author(s):  
André F A Figueiredo ◽  
Natália Teixeira Wnuk ◽  
Amanda O Tavares ◽  
José Rafael Miranda ◽  
Rex A Hess ◽  
...  
Keyword(s):  
Mitotic Activity ◽  
Transition Region ◽  
Sertoli Cells ◽  
Cell Number ◽  
Rete Testis ◽  
Neonatal Rat ◽  
Testis Weight ◽  
Sperm Production ◽  
Neonatal Hypothyroidism ◽  
Male Wistar Rats

The number of Sertoli cells (SCs) ultimately determines the upper limit of sperm production in the testis. Previous studies have shown that thyroid hormones (TH) receptors are abundantly expressed in developing SCs; therefore, it was highly significant to discover that transient neonatal hypothyroidism induced by the goitrogen 6-n-propyl-2-thiouracil (PTU) can extend SCs proliferation beyond the first 2 weeks postnatal and increase testis weight and sperm production. Further studies concluded that treatment must begin before day 8 post birth in rats. Recent studies, however, showed that SCs present in the transition region at the rete testis exhibit a more immature phenotype and have prolonged mitotic activity, which led to the hypothesis that SCs in this region will retain the capacity to respond to PTU treatment over a longer period of time. In the present study, male Wistar rats were treated with PTU from days 21 to 40 and were evaluated at 40 and 160 days of age. Similar to neonatal rat SCs, it was demonstrated that prepubertal SCs in the transition region have a high mitotic activity and are highly sensitive to TH levels. This delayed, transient hypothyroidism resulted in significantly increased testis weight, SCs number and daily sperm production. The results demonstrate for the first time that Sertoli cells showing plasticity in the transition region can be stimulated to increase proliferation and contribute to a late stage surge in testis weight and sperm output.

scholarly journals The relationship of daily sperm production with number of Sertoli cells and testicular size in adult horses: role of primitive spermatogonia

Reproduction ◽  
1994 ◽  
Vol 100 (1) ◽  
pp. 315-321 ◽  
Author(s):  
L. Johnson ◽  
G. K. Carter ◽  
D. D. Varner ◽  
T. S. Taylor ◽  
T. L. Blanchard ◽  
...  
Keyword(s):  
Sertoli Cells ◽  
Sperm Production ◽  
Testicular Size ◽  
Relationship Of ◽  
The Relationship ◽  
Daily Sperm Production
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