Stimulation of the Adenyl Cyclase-Cyclic AMP System in the Thyroid of the Rat1

Endocrinology ◽  
1973 ◽  
Vol 92 (5) ◽  
pp. 1349-1353 ◽  
Author(s):  
M. ZAKARIJA ◽  
J. M. MC KENZIE ◽  
C. H. BASTOMSKY
Keyword(s):  
Cyclic Amp ◽  
Adenyl Cyclase ◽  
Amp System ◽  
Stimulation Of

Effects of chlorpromazine, propranolol and phospholipase C on thyrotropin and prostaglandin stimulation of adenyl cyclase-cyclic AMP system in dog thyroid slices

Metabolism ◽  
1970 ◽  
Vol 19 (12) ◽  
pp. 1109-1118 ◽  
Author(s):  
Kamejiro Yamashita ◽  
Gail Bloom ◽  
Barbara Rainard ◽  
Uriel Zor ◽  
James B. Field
Keyword(s):  
Cyclic Amp ◽  
Phospholipase C ◽  
Adenyl Cyclase ◽  
Amp System ◽  
Stimulation Of

STIMULATION OF GROWTH HORMONE SECRETION IN MONKEYS BY ADRENALIN, PITRESSIN AND ADENOSINE-3′5′-CYCLIC MONOPHOSPHORIC ACID (3′5′-AMP)

1968 ◽  
Vol 59 (3) ◽  
pp. 390-396 ◽  
Author(s):  
J. J. Gagliardino ◽  
J. M. Martin
Keyword(s):  
Growth Hormone ◽  
Cyclic Amp ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Adenyl Cyclase ◽  
Serum Growth Hormone ◽  
Stimulatory Action ◽  
Amp System ◽  
Gh Secretion ◽  
Stimulation Of

ABSTRACT Serum growth hormone (GH) levels were measured by immunoassay in anaesthetized, non-fasted female Rhesus monkeys. Adrenalin and Pitressin® administration significantly stimulated growth hormone secretion. I. v. injection of adenosine-3′5′-cyclic monophosphoric acid (3′5′-AMP) mimicked the stimulatory action of both adrenalin and Pitressin. The stimulation of GH secretion by 3′5′-AMP was blocked by dihydroergotamine. These results suggest that the effect of either adrenalin or Pitressin or both on GH secretion is mediated by the adenyl-cyclase – cyclic AMP system. The additional observation that Pitressin depresses at the same time the release of insulin may indicate that the adenyl-cyclase – cyclic AMP system acts as a common intermediate in the growth hormone-insulin balance.

Histamine receptors and cyclic AMP

1980 ◽  
Vol 58 (9) ◽  
pp. 1023-1030 ◽  
Author(s):  
John H. McNeill
Keyword(s):  
Adipose Tissue ◽  
Gastric Mucosa ◽  
Cyclic Amp ◽  
Adenylate Cyclase ◽  
Histamine Receptors ◽  
Rat Uterus ◽  
Receptor Stimulation ◽  
Amp System ◽  
Organ Systems ◽  
Stimulation Of

The identification and characterization of histamine receptors in the organ systems of various species has been made possible in recent years by the introduction of relatively selective agonists and antagonists of H1 and H2 receptors. H2 receptors have now been clearly demonstrated in gastric mucosa, heart, rat uterus, brain, and adipose tissue. Less well-defined H2 receptor systems have also been described in the vasculature, bronchioles, and other smooth muscles as well as in the thyroid gland and lymphocytes. In tissues where it has been examined a close correlation between H2 receptors and the adenylate cyclase – cyclic AMP system has been found. With the exception of the central nervous system stimulation of H1 receptors does not seem to be involved with cyclic AMP. In the case of the brain the H1 receptor stimulation of adenylate cyclase can be differentiated from H2 receptor stimulation of the enzyme by the use of blocking agents and by the fact that the H1 receptor response is enhanced in the presence of adenosine. Studies of the involvement of histamine with the adenylate cyclase – cyclic AMP system have been concentrated on such tissues as gastric mucosa, heart, rat uterus, brain, and adipose tissue. The present review will concentrate on the literature concerning those tissues.

Transepithelial Potential Changes During Stimulation of Isolated Salivary Glands with 5-Hydroxytryptamine and Cyclic Amp

1972 ◽  
Vol 56 (1) ◽  
pp. 139-153
Author(s):  
MICHAEL J. BERRIDGE ◽  
WILLIAM T. PRINCE
Keyword(s):  
Cyclic Amp ◽  
Salivary Glands ◽  
Electrical Response ◽  
Cation Transport ◽  
Anion Transport ◽  
Adenyl Cyclase ◽  
Positive Potential ◽  
Dose Dependent ◽  
Stimulation Of

1. The role of cyclic AMP in mediating the action of 5-HT on salivary glands has been studied by measuring transepithelial potentials. 2. The lumen of unstimulated glands is 4 mV positive but becomes 12 mV negative after treatment with 5-HT (10-8M). Both the potential and the secretory responses to 5-HT are dose-dependent over the same concentration range. 3. The electrical response of salivary glands to cyclic AMP is qualitatively different to that of 5-HT; instead of going negative the potential goes more positive. 4. An increase in positive potential is also observed after treatment with theophylline (10-2M), or when glands are stimulated with 5-HT in a chloride-free saline. 5. These results are consistent with the idea that 5-HT has two actions. One is to stimulate the enzyme adenyl cyclase to synthesize cyclic AMP, which, in turn, stimulates cation transport. The other is to increase anion transport by a mechanism which is independent of cyclic AMP.

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