Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells.

Endocrinology ◽  
1995 ◽  
Vol 136 (10) ◽  
pp. 4315-4322 ◽  
Author(s):  
T Tsakiridis ◽  
H E McDowell ◽  
T Walker ◽  
C P Downes ◽  
H S Hundal ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Amino Acid ◽  
Glucose Transport ◽  
Amino Acid Transport ◽  
Muscle Cells ◽  
Multiple Roles ◽  
Skeletal Muscle Cells ◽  
Acid Transport ◽  
Phosphatidylinositol 3 Kinase ◽  
L6 Skeletal Muscle Cells

Ceramide down‐regulates System A amino acid transport and protein synthesis in rat skeletal muscle cells

2004 ◽  
Vol 19 (3) ◽  
pp. 1-24 ◽  
Author(s):  
Russell Hyde ◽  
Eric Hajduch ◽  
Darren J. Powell ◽  
Peter M. Taylor ◽  
Harinder S. Hundal
Keyword(s):  
Skeletal Muscle ◽  
Protein Synthesis ◽  
Amino Acid ◽  
Amino Acid Transport ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Acid Transport ◽  
Rat Skeletal Muscle ◽  
System A

Effects of prior exercise on the action of insulin-like growth factor I in skeletal muscle

1992 ◽  
Vol 263 (2) ◽  
pp. E340-E344 ◽  
Author(s):  
E. J. Henriksen ◽  
L. L. Louters ◽  
C. S. Stump ◽  
C. M. Tipton
Keyword(s):  
Skeletal Muscle ◽  
Amino Acid ◽  
Growth Factor ◽  
Glucose Transport ◽  
Amino Acid Transport ◽  
Acid Transport ◽  
Factor I ◽  
System A ◽  
Prior Exercise ◽  
Igf I

Prior exercise increases insulin sensitivity for glucose and system A neutral amino acid transport activities in skeletal muscle. Insulin-like growth factor I (IGF-I) also activates these transport processes in resting muscle. It is not known, however, whether prior exercise increases IGF-I action in muscle. Therefore we determined the effect of a single exhausting bout of swim exercise on IGF-I-stimulated glucose transport activity [assessed by 2-deoxy-D-glucose (2-DG) uptake] and system A activity [assessed by alpha-(methylamino)isobutyric acid (MeAIB) uptake] in the isolated rat epitrochlearis muscle. When measured 3.5 h after exercise, the responses to a submaximal concentration (0.2 nM), but not a maximal concentration (13.3 nM), of insulin for activation of 2-DG uptake and MeAIB uptake were enhanced. In contrast, prior exercise increased markedly both the submaximal (5 nM) and maximal (20 nM) responses to IGF-I for activation of 2-DG uptake, whereas only the submaximal response to IGF-I (3 nM) for MeAIB uptake was enhanced after exercise. We conclude that 1) prior exercise significantly enhances the response to a submaximal concentration of IGF-I for activation of the glucose transport and system A neutral amino acid transport systems in skeletal muscle and 2) the enhanced maximal response for IGF-I action after exercise is restricted to the signaling pathway for activation of the glucose transport system.

scholarly journals Dietary ω 3 fatty acid alters prostaglandin synthesis, glucose transport and protein turnover in skeletal muscle of healthy and diabetic rats

1992 ◽  
Vol 286 (2) ◽  
pp. 405-411 ◽  
Author(s):  
P S Sohal ◽  
V E Baracos ◽  
M T Clandinin
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acids ◽  
Amino Acid ◽  
Glucose Transport ◽  
Amino Acid Transport ◽  
Protein Turnover ◽  
Diabetic Rats ◽  
Omega 3 Fatty Acids ◽  
Acid Transport ◽  
Omega 3

The present study was designed to determine if dietary-fat-induced alterations in the fatty acid composition of skeletal-muscle lipid alters insulin-dependent and basal muscle metabolism, including glucose and amino acid transport, prostaglandin (PG) synthesis and protein turnover. Rats were fed on high-fat semi-purified diets providing 19% or 1% omega 3 fatty acids in the form of fish oil, for 6 weeks. After 3 weeks, half of the rats were made diabetic by a single injection of streptozotocin (50 mg/kg body wt.). After a further 3 weeks, contralateral epitrochlearis and extensor digitorum longus (EDL) muscles from each rat were incubated in vitro. High levels of dietary omega 3 fatty acids decreased PGE2 and PGF2 alpha synthesis in EDL and epitrochlearis muscle (P less than 0.0001). Diabetes and insulin had no effect on PG synthesis. Diet did not alter basal glucose or amino acid transport in EDL muscle from healthy or diabetic rats. Insulin increased glucose and amino acid transport (P less than 0.0001); the increase in glucose transport by insulin was significantly greater in muscles of rats fed on high levels of omega 3 fatty acids (P less than 0.05). Epitrochlearis from rats fed on high levels of omega 3 fatty acids showed decreased net protein degradation in the presence and absence of insulin, owing to decreased rates of protein degradation and synthesis. The data suggest that high levels of dietary omega 3 fatty acids that alter muscle membrane composition also result in alterations in glucose transport and the metabolism of muscle protein.

Mechanism of L-lactic Acid Transport in L6 Skeletal Muscle Cells

2004 ◽  
Vol 19 (5) ◽  
pp. 363-368 ◽  
Author(s):  
Masaki Kobayashi ◽  
Shirou Itagaki ◽  
Takeshi Hirano ◽  
Ken Iseki
Keyword(s):  
Skeletal Muscle ◽  
Lactic Acid ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Acid Transport ◽  
L6 Skeletal Muscle Cells

scholarly journals Protein Kinase C (PKC)-α Activation Inhibits PKC-ζ and Mediates the Action of PED/PEA-15 on Glucose Transport in the L6 Skeletal Muscle Cells

Diabetes ◽  
2001 ◽  
Vol 50 (6) ◽  
pp. 1244-1252 ◽  
Author(s):  
Gerolama Condorelli ◽  
Giovanni Vigliotta ◽  
Alessandra Trencia ◽  
Maria Alessandra Maitan ◽  
Matilde Caruso ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Glucose Transport ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Kinase C ◽  
Pkc Ζ ◽  
L6 Skeletal Muscle Cells
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