scholarly journals Involvement of the Sst1 Somatostatin Receptor Subtype in the Intrahypothalamic Neuronal Network Regulating Growth Hormone Secretion: Anin Vitroandin VivoAntisense Study1

Endocrinology ◽  
2000 ◽  
Vol 141 (3) ◽  
pp. 967-979 ◽  
Author(s):  
Christophe Lanneau ◽  
Marie Thérèse Bluet-Pajot ◽  
Philippe Zizzari ◽  
Zsolt Csaba ◽  
Pascal Dournaud ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Neuronal Network ◽  
Somatostatin Receptor ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Receptor Subtype

Somatostatin family of peptides and its receptors in fish

2000 ◽  
Vol 78 (12) ◽  
pp. 1053-1066 ◽  
Author(s):  
Xinwei Lin ◽  
Carla J Otto ◽  
Rodolfo Cardenas ◽  
Richard E Peter
Keyword(s):  
Growth Hormone ◽  
Primary Structure ◽  
Somatostatin Receptor ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Cellular Mechanisms ◽  
Cell Type Specific ◽  
Considerable Homology ◽  
Negative Coupling ◽  
Type 3

Somatostatin (SRIF or SS) is a phylogenetically ancient, multigene family of peptides. SRIF-14 is conserved with identical primary structure in species of all classes of vertebrates. The presence of multiple SRIF genes has been demonstrated in a number of fish species and could extend to tetrapods. Three distinct SRIF genes have been identified in goldfish. One of these genes, which encodes [Pro2]SRIF-14, is also present in sturgeon and African lungfish, and is closely associated with amphibian [Pro2,Met13]SRIF-14 gene and mammalian cortistatin gene. The post-translational processing of SRIF precursors could result in multiple forms of mature SRIF peptides, with differential abundance and tissue- or cell type-specific patterns. The main neuroendocrine role of SRIF-14 peptide that has been determined in fish is the inhibition of pituitary growth hormone secretion. The functions of SRIF-14 variant or larger forms of SRIF peptide and the regulation of SRIF gene expression remain to be explored. Type 1 and type 2 SRIF receptors have been identified from goldfish and a type 3 SRIF receptor has been identified from an electric fish. Fish SRIF receptors display considerable homology with mammalian counterparts in terms of primary structure and negative coupling to adenylate cyclase. Although additional types of receptors remain to be determined, identification of the multiple gene family of SRIF peptides and multiple types of SRIF receptors opens a new avenue for the study of physiological roles of SRIF, and the molecular and cellular mechanisms of SRIF action in fish.Key words: somatostatin, somatostatin receptor, growth hormone, fish.

scholarly journals Identification of the Somatostatin Receptor Subtypes (sst) Mediating the Divergent, Stimulatory/Inhibitory Actions of Somatostatin on Growth Hormone Secretion

Endocrinology ◽  
2006 ◽  
Vol 147 (6) ◽  
pp. 2902-2908 ◽  
Author(s):  
Raúl M. Luque ◽  
Mario Durán-Prado ◽  
Socorro García-Navarro ◽  
Francisco Gracia-Navarro ◽  
Rhonda D. Kineman ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Somatostatin Receptor ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Receptor Subtypes ◽  
Somatostatin Receptor Subtypes

scholarly journals Somatostatin Receptor-Specific Analogs: Effects on Cell Proliferation and Growth Hormone Secretion in Human Somatotroph Tumors1

2001 ◽  
Vol 86 (7) ◽  
pp. 2976-2981 ◽  
Author(s):  
Daniel C. Danila ◽  
Jaafar N. Sleiman Haidar ◽  
Xun Zhang ◽  
Laurence Katznelson ◽  
Michael D. Culler ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cell Proliferation ◽  
Somatostatin Receptor ◽  
Hormone Secretion ◽  
Growth Hormone Secretion
Sign in / Sign up

Export Citation Format

Share Document