A Long-Acting Human Growth Hormone With Delayed Clearance (VRS-317): Results of a Double-Blind, Placebo-Controlled, Single Ascending Dose Study in Growth Hormone–Deficient Adults

A double‐blind, placebo‐controlled single ascending dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of HM15136 , a novel long‐acting glucagon analogue, in healthy subjects

Diabetes Obesity and Metabolism ◽

10.1111/dom.14590 ◽

2021 ◽

Author(s):

Ki Young Huh ◽

Jun Gi Hwang ◽

Wonjung Shin ◽

SeungJae Baek ◽

JaeDuk Choi ◽

...

Keyword(s):

Healthy Subjects ◽

Pharmacokinetics And Pharmacodynamics ◽

Double Blind ◽

Double Blind Placebo ◽

Dose Study ◽

Long Acting ◽

Recombinant Human Growth Hormone and Rosiglitazone for Abdominal Fat Accumulation in HIV-Infected Patients with Insulin Resistance: A Randomized, Double-Blind, Placebo-Controlled, Factorial Trial

PLoS ONE ◽

10.1371/journal.pone.0061160 ◽

2013 ◽

Vol 8 (4) ◽

pp. e61160 ◽

Cited By ~ 10

Author(s):

Marshall J. Glesby ◽

Jeanine Albu ◽

Ya-Lin Chiu ◽

Kirsis Ham ◽

Ellen Engelson ◽

...

Keyword(s):

Insulin Resistance ◽

Growth Hormone ◽

Human Growth Hormone ◽

Human Growth ◽

Abdominal Fat ◽

Double Blind ◽

Fat Accumulation ◽

Double Blind Placebo ◽

Factorial Trial

Faculty Opinions recommendation of Recombinant human growth hormone and rosiglitazone for abdominal fat accumulation in HIV-infected patients with insulin resistance: a randomized, double-blind, placebo-controlled, factorial trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718006638.793477602 ◽

2013 ◽

Author(s):

J Michael Kilby

Keyword(s):

Insulin Resistance ◽

Growth Hormone ◽

Human Growth Hormone ◽

Human Growth ◽

Abdominal Fat ◽

Double Blind ◽

Fat Accumulation ◽

Double Blind Placebo ◽

Factorial Trial

948-P: A Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HM15136, a Novel Long-Acting Glucagon Analogue, in Healthy Subjects

Diabetes ◽

10.2337/db20-948-p ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 948-P

Author(s):

KI YOUNG HUH ◽

WONJUNG SHIN ◽

EUNHYE BAEK ◽

SUJIN SEO ◽

WOOSUN LEE ◽

...

Keyword(s):

Healthy Subjects ◽

Pharmacokinetics And Pharmacodynamics ◽

Double Blind ◽

Double Blind Placebo ◽

Dose Study ◽

Long Acting ◽

Application of a Pharmacokinetic-Pharmacodynamic Model for a Pegylated, Long-Acting Human Growth Hormone Developed for Once-Weekly Administration.

10.1210/endo-meetings.2010.part2.p8.p2-351 ◽

2010 ◽

pp. P2-351-P2-351

Author(s):

T Klitgaard ◽

J Madsen ◽

BS Hansen ◽

MH Rasmussen

Keyword(s):

Growth Hormone ◽

Human Growth Hormone ◽

Human Growth ◽

Pharmacodynamic Model ◽

Weekly Administration ◽

Long Acting

Growth after recombinant human growth hormone treatment in children with chronic renal failure: Report of a multicenter randomized double-blind placebo-controlled study

The Journal of Pediatrics ◽

10.1016/s0022-3476(94)70358-2 ◽

1994 ◽

Vol 124 (3) ◽

pp. 374-382 ◽

Cited By ~ 170

Author(s):

Richard N. Fine ◽

Edward C. Kohaut ◽

Douglas Brown ◽

Andrew J. Perlman

Keyword(s):

Growth Hormone ◽

Renal Failure ◽

Chronic Renal Failure ◽

Growth Hormone Treatment ◽

Human Growth ◽

Hormone Treatment ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo

(479) A phase 2a, randomized, double-blind, placebo-controlled, single ascending-dose study to evaluate the safety and efficacy of naldemedine in patients with chronic non-cancer pain and opioid-induced bowel dysfunction

Journal of Pain ◽

10.1016/j.jpain.2016.01.456 ◽

2016 ◽

Vol 17 (4) ◽

pp. S94 ◽

Cited By ~ 2

Author(s):

L. Webster ◽

T. Nagata ◽

T. Yamada ◽

J. Arjona Ferreira

Keyword(s):

Cancer Pain ◽

Bowel Dysfunction ◽

Double Blind ◽

Safety And Efficacy ◽

Double Blind Placebo ◽

Dose Study ◽

Development of a long acting human growth hormone analog suitable for once a week dosing

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.11.104 ◽

2013 ◽

Vol 23 (2) ◽

pp. 402-406 ◽

Cited By ~ 11

Author(s):

Moorthy S.S. Palanki ◽

Abhijit Bhat ◽

Ben Bolanos ◽

Florence Brunel ◽

Joselyn Del Rosario ◽

...

Keyword(s):

Growth Hormone ◽

Human Growth Hormone ◽

Human Growth ◽

Hormone Analog ◽

Long Acting

P02-48 A novel long acting human growth hormone (VRS-317): sustained and dose dependent biological activity in growth hormone deficient adults

Growth Hormone & IGF Research ◽

10.1016/s1096-6374(12)60177-4 ◽

2012 ◽

Vol 22 ◽

pp. S67

Author(s):

G.M. Bright ◽

K.C.J. Yuen ◽

G.S. Conway ◽

V. Popovic-Brkic ◽

G.R. Merriam ◽

...

Keyword(s):

Growth Hormone ◽

Biological Activity ◽

Human Growth Hormone ◽

Human Growth ◽

Long Acting ◽

Dose Dependent

Somatic characteristics and cardiovascular risk factors in growth hormone deficiency: A randomized, double-blind, placebo-controlled study of the effect of treatment with recombinant human growth hormone

American Journal of Human Biology ◽

10.1002/ajhb.20055 ◽

2004 ◽

Vol 16 (5) ◽

pp. 533-543 ◽

Cited By ~ 8

Author(s):

W. Bell ◽

J.S. Davies ◽

W.D. Evans ◽

M.F. Scanlon ◽

R. Mullen

Keyword(s):

Risk Factors ◽

Growth Hormone ◽

Cardiovascular Risk ◽

Human Growth ◽

Hormone Deficiency ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo ◽

Effect Of Treatment