scholarly journals Variants inFSHBAre Associated With Polycystic Ovary Syndrome and Luteinizing Hormone Level in Han Chinese Women

2016 ◽  
Vol 101 (5) ◽  
pp. 2178-2184 ◽  
Author(s):  
Ye Tian ◽  
Han Zhao ◽  
Haitao Chen ◽  
Yingqian Peng ◽  
Linlin Cui ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Polycystic Ovary Syndrome ◽  
Hormone Level ◽  
Chinese Women ◽  
Polycystic Ovary ◽  
Han Chinese ◽  
Luteinizing Hormone Level ◽  
Ovary Syndrome

scholarly journals Differentiated combined therapy of polycystic ovary syndrome for patients with obesity

2014 ◽  
Vol 18 (1 (69)) ◽  
Author(s):  
Y. V. Onyshchenko ◽  
N. N. Rozhkovska
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Hormone Level ◽  
Polycystic Ovary ◽  
Combined Therapy ◽  
Infertility Treatment ◽  
Luteinizing Hormone Level ◽  
Complex Treatment ◽  
Ovary Syndrome ◽  
Explicit Correlation ◽  
Positive Effect

Obesity is one of pathognomonic symptoms of polycystic ovary syndrome (PCOS). According to different data sources its frequency among patients with PCOS ranges from 45 to 50 %. Efficiency of differentiated complex treatment of patients with PCOS is studied with taking body mass index (BMI) into account. Obtained data show positive effect of combined infertility treatment that included Metformin for insulin resistance correction as menstrual function and ovulation normalization in 58,7 % of patients with PCOS. Treatment with Metformin results in normalization of luteinizing hormone level which has explicit correlation with risk of 1st trimester miscarriages.

scholarly journals Association of +45G15G(T/G) and +276(G/T) polymorphisms in the ADIPOQ gene with polycystic ovary syndrome among Han Chinese women

2008 ◽  
Vol 158 (2) ◽  
pp. 255-260 ◽  
Author(s):  
Ning Zhang ◽  
Yu-Hua Shi ◽  
Cui-Fang Hao ◽  
Harvest F Gu ◽  
Yuan Li ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Chinese Women ◽  
Polycystic Ovary ◽  
Han Chinese ◽  
Model Assessment ◽  
Nucleotide Polymorphisms ◽  
Ovary Syndrome ◽  
Adipoq Gene ◽  
Insulin Levels ◽  
Increased Risk

ObjectivePolycystic ovary syndrome (PCOS) is frequently associated with insulin resistance (IR) and consequently with increased risk of metabolic disorders. Adiponectin is the most abundant adipocytokine and may play a role in the regulation of insulin sensitivity and IR in PCOS. The aim of the present study was to evaluate the genetic influence of the adiponectin (ADIPOQ) gene polymorphisms in the development of PCOS among Han Chinese women.MethodsTwo single nucleotide polymorphisms (SNPs),+45G15G(T/G) and +276(G/T), in the ADIPOQ gene were genotyped in 120 patients with PCOS and 120 healthy control subjects. All of them were Han Chinese women.ResultsBoth SNPs were found to be significantly associated with PCOS (P=0.021, odds ratios=1.629, 95% confidence intervals: 1.074–2.469 and P=0.015, 1.576, 1.091–2.279 respectively). In SNP +276(G/T), the allele G was found to be significantly associated with increased fasting insulin levels, homeostasis model assessment to assess IR index, and area under the curve glucose levels, but decreased glucose and insulin ratio in the PCOS patients. Furthermore, the patients carrying genotypes G/G and G/T had significantly decreased levels of serum adiponectin (6.16±3.18 plus 5.93±3.23 vs 8.96±3.21 μg/ml, P=0.030) compared with the patients with genotype T/T.ConclusionsThe present study provides evidence that SNPs +45G15G(T/G) and +276(G/T) in the ADIPOQ gene are associated with PCOS in Han Chinese women. SNP +276(G/T) may contribute to an impact of insulin levels and IR, which are implicated in the susceptibility for PCOS.

Evaluation of the association between GHR exon 3 polymorphism and polycystic ovary syndrome among Han Chinese women

2011 ◽  
Vol 21 (5) ◽  
pp. 248-251 ◽  
Author(s):  
Yun Shen ◽  
Laicheng Wang ◽  
Yueran Zhao ◽  
Li You ◽  
Ling Geng ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Chinese Women ◽  
Polycystic Ovary ◽  
Han Chinese ◽  
Ovary Syndrome
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