The combined effect of tumor-produced parathyroid hormone-related protein and transforming growth factor-alpha enhance hypercalcemia in vivo and bone resorption in vitro

1993 ◽  
Vol 77 (1) ◽  
pp. 40-45 ◽  
Author(s):  
T. A. Guise
Keyword(s):  
Parathyroid Hormone ◽  
Growth Factor ◽  
Bone Resorption ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Alpha ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein ◽  
Factor Alpha

Effect of transforming growth factor-alpha and parathyroid hormone-related protein on phosphate transport in renal cells

1990 ◽  
Vol 259 (6) ◽  
pp. F929-F935 ◽  
Author(s):  
L. Pizurki ◽  
R. Rizzoli ◽  
J. Caverzasio ◽  
J. P. Bonjour
Keyword(s):  
Parathyroid Hormone ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Alpha ◽  
Related Protein ◽  
Renal Cells ◽  
Parathyroid Hormone Related Protein ◽  
Pi Transport ◽  
Factor Alpha ◽  
In Cells

The decrease in plasma Pi concentration and in Pi tubular reabsorption that is often encountered in malignant hypercalcemia may be ascribed to a tumor-produced parathyroid hormone (PTH)-related protein. However, tumors are known to synthesize a variety of substances, among which is transforming growth factor-alpha (TGF-alpha). We investigated the effects of TGF-alpha on Na-dependent Pi transport and on the response to PTH-related protein in cultured opossum renal epithelial cells. TGF-alpha caused a concentration- and time-dependent decrease in Na-dependent Pi transport. The inhibition of Na-dependent Pi transport was detectable by 14 h of incubation and maximal by 24 h. At that time, a concentration of 10 ng/ml of TGF-alpha produced a 35 +/- 1% inhibition. This was not associated with any change in prostaglandin production. The adenosine 3',5'-cyclic monophosphate (cAMP) response to PTH-related protein, PTH, prostaglandin E2 or forskolin, but not to pertussis toxin, was diminished in cells treated with TGF-alpha for 24 h. Similar effects on Na-dependent Pi transport and cAMP production were observed in cells incubated with epidermal growth factor. The inhibition of Na-dependent Pi transport induced by either PTH-related protein or PTH was reduced after incubation with TGF-alpha. Thus two different tumoral products, TGF-alpha and PTH-related protein, are each capable of inhibiting Na-dependent Pi transport in cultured renal cells. Both peptides may also interact and influence the effects of each other on renal Pi transport.

scholarly journals Human transforming growth factor-alpha stimulates bone resorption in vitro.

1985 ◽  
Vol 76 (5) ◽  
pp. 2016-2019 ◽  
Author(s):  
P H Stern ◽  
N S Krieger ◽  
R A Nissenson ◽  
R D Williams ◽  
M E Winkler ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Resorption ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Alpha ◽  
Factor Alpha

Effect of Transforming Growth Factor-β1 on Parathyroid Hormone-Related Protein Secretion and mRNA Expression by Normal Human Keratinocytes In Vitro

Endocrine ◽  
1998 ◽  
Vol 8 (3) ◽  
pp. 291-300 ◽  
Author(s):  
James R. Werkmeister ◽  
Eric A. G. Blomme ◽  
Michelle T. Weckmann ◽  
Andrea Gröne ◽  
Laurie K. McCauley ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Human Keratinocytes ◽  
Transforming Growth Factor Β1 ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein ◽  
Normal Human Keratinocytes ◽  
Normal Human

Biological activity of a transforming growth factor-alpha-Pseudomonas exotoxin fusion protein in vitro and in vivo

1991 ◽  
Vol 7 (3) ◽  
pp. 203-207 ◽  
Author(s):  
David C. Heimbrook ◽  
Steven M. Stirdivant ◽  
Janet D. Ahern ◽  
Nancy L. Balishin ◽  
Denis R. Patrick ◽  
...  
Keyword(s):  
Biological Activity ◽  
Growth Factor ◽  
Fusion Protein ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Alpha ◽  
Pseudomonas Exotoxin ◽  
Factor Alpha

Stimulation of bone resorption in vitro by synthetic transforming growth factor-alpha

Science ◽  
1985 ◽  
Vol 228 (4702) ◽  
pp. 1007-1009 ◽  
Author(s):  
K. Ibbotson ◽  
D. Twardzik ◽  
S. D'Souza ◽  
W. Hargreaves ◽  
G. Todaro ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Resorption ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Alpha ◽  
Factor Alpha ◽  
Stimulation Of

scholarly journals Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro.

1986 ◽  
Vol 83 (7) ◽  
pp. 2228-2232 ◽  
Author(s):  
K. J. Ibbotson ◽  
J. Harrod ◽  
M. Gowen ◽  
S. D'Souza ◽  
D. D. Smith ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Resorption ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Alpha ◽  
Factor Alpha
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