Priming of human polymorphonuclear neutrophilic leukocytes by insulin- like growth factor I: increased phagocytic capacity, complement receptor expression, degranulation, and oxidative burst

1995 ◽  
Vol 80 (6) ◽  
pp. 1948-1955 ◽  
Author(s):  
R. Bjerknes
Keyword(s):  
Growth Factor ◽  
Oxidative Burst ◽  
Receptor Expression ◽  
Complement Receptor ◽  
Insulin Like Growth Factor ◽  
Phagocytic Capacity ◽  
Factor I ◽  
Neutrophilic Leukocytes ◽  
Growth Factor I

Increased neutrophil insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced functional capacity in patients with untreated Laron syndrome

1997 ◽  
Vol 136 (1) ◽  
pp. 92-95 ◽  
Author(s):  
Robert Bjerknes ◽  
Per Vesterhus ◽  
Dagfinn Aarskog
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Functional Capacity ◽  
Oxidative Burst ◽  
Insulin Like Growth Factor ◽  
Laron Syndrome ◽  
Phagocytic Capacity ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

Abstract Insulin-like growth factor-I (IGF-I) is a growth hormone-dependent peptide with growth and immunoregulatory properties, and in Laron syndrome growth hormone insensitivity induces impaired production of IGF-I. In the present study we have determined the neutrophil expression of IGF-I receptors (IGF-I-Rs), as well as the IGF-I-induced priming of neutrophil functional capacity, in two children with Laron syndrome treated with recombinant human IGF-I, and in age-matched controls. Before treatment, the patient neutrophil expression of IGF-I-Rs was significantly increased. However, with replacement therapy the neutrophil IGF-I-R expression was downregulated to levels similar to those of the controls within one month. In the patients, the phagocytic capacity and oxidative burst of unprimed neutrophils were normal and similar to controls before the start of treatment. Moreover, IGF-I efficiently primed both patient and control neutrophils to increase their phagocytic capacity and oxidative burst in vitro. However, before therapy, the priming response to IGF-I was significantly stronger in the neutrophils in the patients than in the controls. The present data support earlier studies by us and others demonstrating that IGF-I is a potent regulator of mature neutrophil function, but also suggest that these leukocytes may function normally in the presence of very low levels of IGF-I in vivo. European Journal of Endocrinology 136 92–95

scholarly journals Insulin-Like Growth Factor-I Receptor Expression Regulates Neuroblastoma Metastasis to Bone

2006 ◽  
Vol 66 (13) ◽  
pp. 6570-6578 ◽  
Author(s):  
Cynthia M. van Golen ◽  
Tracy S. Schwab ◽  
Bhumsoo Kim ◽  
Mary E. Soules ◽  
Sang Su Oh ◽  
...  
Keyword(s):  
Growth Factor ◽  
Receptor Expression ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

scholarly journals A Role of Insulin-Like Growth Factor I for Follicle-Stimulating Hormone Receptor Expression in Rat Granulosa Cells1

2000 ◽  
Vol 62 (2) ◽  
pp. 325-333 ◽  
Author(s):  
Takashi Minegishi ◽  
Takashi Hirakawa ◽  
Hiroshi Kishi ◽  
Kazuko Abe ◽  
Yumiko Abe ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hormone Receptor ◽  
Follicle Stimulating Hormone ◽  
Receptor Expression ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I ◽  
Hormone Receptor Expression ◽  
Stimulating Hormone
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