Twenty-Four Hour Pattern of Luteinizing Hormone Secretion in Normal Men with Sleep Stage Recording

Abstract. To investigate the effects of the 1,5-benzodiazepine, clobazam, on LH secretion in normal men, LH pulsatile secretion was defined after oral administration of 40 mg of clobazam or a placebo to 6 healthy male volunteers, according to a randomized cross-over design. LH pulse frequency increased significantly from a mean of 3.8 (range 3–5 pulses/8 h after placebo, to a mean of 5 (range 4–7) pulses/8 h (P< 0.05), after clobazam. Mean LH concentrations and peak amplitudes did not change significantly. These results suggest that clobazam mediates its effects on LH secretion at the hypothalamic level by increasing the frequency of episodic GnRH release.

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The Effects of Aging in Normal Men on Bioavailable Testosterone and Luteinizing Hormone Secretion: Response to Clomiphene Citrate*

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem-65-6-1118 ◽

1987 ◽

Vol 65 (6) ◽

pp. 1118-1126 ◽

Cited By ~ 157

Author(s):

JOYCE S. TENOVER ◽

ALVIN M. MATSUMOTO ◽

STEPHEN R. PLYMATE ◽

WILLIAM J. BREMNER

Keyword(s):

Luteinizing Hormone ◽

Clomiphene Citrate ◽

Hormone Secretion ◽

Luteinizing Hormone Secretion ◽

Bioavailable Testosterone ◽

Normal Men ◽

Effects Of Aging

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Acute effects of testosterone infusion and naloxone on luteinizing hormone secretion in normal men.

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem.75.5.1430081 ◽

1992 ◽

Vol 75 (5) ◽

pp. 1215-1219

Author(s):

G B Kletter ◽

C M Foster ◽

I Z Beitins ◽

J C Marshall ◽

R P Kelch

Keyword(s):

Luteinizing Hormone ◽

Hormone Secretion ◽

Acute Effects ◽

Luteinizing Hormone Secretion ◽

Normal Men

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Androgenic and oestrogenic steroid participation in feedback control of luteinizing hormone secretion in male sheep

Acta Endocrinologica ◽

10.1530/acta.0.1020499 ◽

1983 ◽

Vol 102 (4) ◽

pp. 499-504 ◽

Cited By ~ 15

Author(s):

M. J. D'Occhio ◽

B. D. Schanbacher ◽

J. E. Kinder

Keyword(s):

Luteinizing Hormone ◽

Pulse Generator ◽

Hormone Secretion ◽

Pulse Interval ◽

Serum Concentrations ◽

Luteinizing Hormone Secretion ◽

Lh Release ◽

Lh Secretion ◽

Additional Feedback ◽

Male Sheep

Abstract. The acute castrate ram (wether) was used as an experimental model to investigate the site(s) of feedback on luteinizing hormone (LH) by testosterone, dihydrotestosterone and oestradiol. At the time of castration, wethers were implanted subdermally with Silastic capsules containing either crystalline testosterone (three 30 cm capsules), dihydrotestosterone (five 30 cm capsules) or oestradiol (one 6.5 cm capsule). Blood samples were taken at 10 min intervals for 6 h 2 weeks after implantation to determine serum steroid concentrations and to characterize the patterns of LH secretion. Pituitary LH response to exogenous LRH (5 ng/kg body weight) were also determined at the same time. The steroid implants produced serum concentrations of the respective hormones which were either one-third (testosterone) or two-to-four times (dihydrotestosterone, oestradiol) the levels measured in rams at the time of castration. Non-implanted wethers showed rhythmic pulses of LH (pulse interval 40–60 min) and had elevated LH levels (16.1 ± 1.6 ng/ml; mean ± se) 2 weeks after castration. All three steroids suppressed pulsatile LH release and reduced mean LH levels (to below 3 ng/ml) and pituitary LH responses to LRH. Inhibition of pulsatile LH secretion by all three steroids indicated that testosterone as well as its androgenic and oestrogenic metabolites can inhibit the LRH pulse generator in the hypothalamus. Additional feedback on the pituitary was indicated by the dampened LH responses to exogenous LRH.

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