Epidermal Growth Factor (EGF) Receptors in Human Chorionic Gonadotropin-Producing Tumor: Transplantation in Nude Mice and the Effect of EGF on Tumor Growth

1990 ◽  
Vol 71 (2) ◽  
pp. 329-334 ◽  
Author(s):  
YUKITAKA MIYACHI ◽  
TAKASHI TERAZONO ◽  
NORIKO NAGAO ◽  
TORU SHOJI ◽  
MINORU IRIE
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tumor Growth ◽  
Chorionic Gonadotropin ◽  
Nude Mice ◽  
Human Chorionic Gonadotropin ◽  
Egf Receptors ◽  
Tumor Transplantation ◽  
Epidermal Growth

Heterogeneity in Epidermal Growth Factor Responsiveness and Tumor Growth of Human Maxillary Cancer Cell Lines

1992 ◽  
Vol 101 (6) ◽  
pp. 519-524 ◽  
Author(s):  
Sohtaro Komiyama ◽  
Shohji Kudoh ◽  
Katsuko Matsui ◽  
Hiromoto Mizoguchi ◽  
Hiroshi Miyazaki ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tumor Growth ◽  
Cell Lines ◽  
Nude Mice ◽  
Egf Receptor ◽  
Slow Growth ◽  
Maxillary Cancer ◽  
Epidermal Growth ◽  
Intermediate Rate

We have established three cell lines (IMC-2, IMC-3, and IMC-4) from a human maxillary tumor, which exhibited different sensitivities to epidermal growth factor (ECF). It was inhibitory to colony-forming abilities of IMC-3 and IMC-4 cells in culture, while it affected that of IMC-2 cells slightly if at all. The differential sensitivities to EGF among the three cell lines were reproducibly observed when several cell sublines were further established from tumors appearing in nude mice. Saturation-binding kinetics with 125I-EGF showed similar levels of EGF-binding activities among the three cell lines. However, IMC-2, IMC-3, and IMC-4 showed almost similar sensitivities to cisplatin. Autophosphorylation of EGF receptor in the presence of EGF proceeded at similar levels among the three cell lines. Tumor growth was followed in nude mice when IMC-2, IMC-3, and IMC-4 at 1 × 107 cells were inoculated. The IMC-2 tumors enlarged at much faster rates than the other two cell lines. The IMC-4 tumors showed very slow growth rates, and IMC-3 tumors enlarged at an intermediate rate. These data suggest that the maxillary tumor used comprised cell populations that differed in their growth behaviors in response to EGF.

Epidermal growth factor contamination and concentrations of intact human chorionic gonadotropin in commercial preparations

2004 ◽  
Vol 82 (1) ◽  
pp. 232-233 ◽  
Author(s):  
Sarah J Yarram ◽  
Julian Jenkins ◽  
Lawrence A Cole ◽  
Nathan L Brown ◽  
Jonathan R Sandy ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Epidermal Growth
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