Mechanism of Action of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor on Apolipoprotein B-100 Kinetics in Visceral Obesity

Dick C. Chan; Gerald F. Watts; P. Hugh R. Barrett; Trevor A. Mori; Lawrence J. Beilin; Trevor G. Redgrave

doi:10.1210/jcem.87.5.8455

Mechanism of Action of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor on Apolipoprotein B-100 Kinetics in Visceral Obesity

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem.87.5.8455 ◽

2002 ◽

Vol 87 (5) ◽

pp. 2283-2289 ◽

Cited By ~ 18

Author(s):

Dick C. Chan ◽

Gerald F. Watts ◽

P. Hugh R. Barrett ◽

Trevor A. Mori ◽

Lawrence J. Beilin ◽

...

Keyword(s):

Mechanism Of Action ◽

Apolipoprotein B ◽

Reductase Inhibitor ◽

Coenzyme A ◽

Visceral Obesity ◽

Coenzyme A Reductase

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NK-104, a potent 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, decreases apolipoprotein B-100 secretion from Hep G2 cells

Atherosclerosis ◽

10.1016/s0021-9150(99)00018-0 ◽

1999 ◽

Vol 145 (1) ◽

pp. 87-95 ◽

Cited By ~ 14

Author(s):

Chiara Ooyen ◽

Alessia Zecca ◽

Anna Maria Bersino ◽

Alberico L. Catapano

Keyword(s):

Apolipoprotein B ◽

Reductase Inhibitor ◽

Coenzyme A ◽

Hep G2 ◽

Hep G2 Cells ◽

G2 Cells ◽

Coenzyme A Reductase

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NK-104, a potent new 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, enhances posttranslational catabolism of apolipoprotein B-100 and inhibits secretion of apolipoprotein B-100 and triacylglycerols from HepG2 cells

Current Therapeutic Research ◽

10.1016/s0011-393x(99)80021-6 ◽

1999 ◽

Vol 60 (8) ◽

pp. 423-434 ◽

Cited By ~ 14

Author(s):

Teruyoshi Yanagita ◽

Emi Hara ◽

Hiroaki Yotsumoto ◽

Shaikh M. Rahman ◽

Seo-Y. Han ◽

...

Keyword(s):

Apolipoprotein B ◽

Hepg2 Cells ◽

Reductase Inhibitor ◽

Coenzyme A ◽

Coenzyme A Reductase

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Simvastatin, an HMG–Coenzyme A Reductase Inhibitor, Improves Endothelial Function Within 1 Month

Circulation ◽

10.1161/01.cir.95.5.1126 ◽

1997 ◽

Vol 95 (5) ◽

pp. 1126-1131 ◽

Cited By ~ 646

Author(s):

Gerard O'Driscoll ◽

Danny Green ◽

Roger R. Taylor

Keyword(s):

Endothelial Function ◽

Reductase Inhibitor ◽

Coenzyme A ◽

Coenzyme A Reductase

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A hydroxymethylglutaryl coenzyme a reductase inhibitor improves endothelial function within 7 days in patients with chronic hemodialysis

International Journal of Cardiology ◽

10.1016/j.ijcard.2009.05.023 ◽

2010 ◽

Vol 145 (1) ◽

pp. 21-26 ◽

Cited By ~ 10

Author(s):

Noriaki Kishimoto ◽

Toshio Hayashi ◽

Ichiro Sakuma ◽

Hatsuyo Kano-Hayashi ◽

Taku Tsunekawa ◽

...

Keyword(s):

Endothelial Function ◽

Reductase Inhibitor ◽

Coenzyme A ◽

Chronic Hemodialysis ◽

Hydroxymethylglutaryl Coenzyme A Reductase ◽

Coenzyme A Reductase

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Association of cholesterol levels, hydroxymethylglutaryl coenzyme-a reductase inhibitor treatment, and progression of aortic stenosis in the community

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(02)02496-8 ◽

2002 ◽

Vol 40 (10) ◽

pp. 1723-1730 ◽

Cited By ~ 224

Author(s):

Michael F Bellamy ◽

Patricia A Pellikka ◽

Kyle W Klarich ◽

A.Jamil Tajik ◽

Maurice Enriquez-Sarano

Keyword(s):

Aortic Stenosis ◽

Reductase Inhibitor ◽

Coenzyme A ◽

Cholesterol Levels ◽

Hydroxymethylglutaryl Coenzyme A Reductase ◽

Inhibitor Treatment ◽

Coenzyme A Reductase

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Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism ◽

10.1016/0005-2760(90)90139-o ◽

1990 ◽

Vol 1045 (2) ◽

pp. 115-120 ◽

Cited By ~ 129

Author(s):

Teiichiro Koga ◽

Yohko Shimada ◽

Masao Kuroda ◽

Yoshio Tsujita ◽

Kazuo Hasegawa ◽

...

Keyword(s):

Reductase Inhibitor ◽

Cholesterol Synthesis ◽

Coenzyme A ◽

Selective Inhibition ◽

Pravastatin Sodium ◽

Coenzyme A Reductase

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Simultaneous Release of a Hydroxy-Methylglutaryl Coenzyme A Reductase Inhibitor and a Glycoprotein IIb/IIIa Antagonist from a Thermoresponsive NiPAAm/NtBAAm Copolymer System

Journal of Biomaterials and Nanobiotechnology ◽

10.4236/jbnb.2011.21003 ◽

2011 ◽

Vol 02 (01) ◽

pp. 18-27 ◽

Cited By ~ 1

Author(s):

J. A. Hickey ◽

I. Lynch ◽

K. A. Dawson ◽

D. Cox ◽

A. K. Keenan

Keyword(s):

Reductase Inhibitor ◽

Coenzyme A ◽

Coenzyme A Reductase

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Anti-inflammatory Effects of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitor on Acute Coronary Arteritis in A Rabbit Model of Kawasaki Disease

Journal of Vascular Medicine & Surgery ◽

10.4172/2329-6925.1000238 ◽

2015 ◽

Vol 03 (06) ◽

Author(s):

Kenji Hamaoka ◽

Seiichiro Ozawa

Keyword(s):

Kawasaki Disease ◽

Reductase Inhibitor ◽

Coenzyme A ◽

Rabbit Model ◽

Coronary Arteritis ◽

Anti Inflammatory ◽

Coenzyme A Reductase

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Effects of Provastatin, a 3-hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitor, on Glucose Tolerance in Patients With Essential Hypertension

Diabetes Care ◽

10.2337/diacare.16.1.402b ◽

1993 ◽

Vol 16 (1) ◽

pp. 402-404 ◽

Cited By ~ 6

Author(s):

T. Baba ◽

T. Kodama ◽

Y. Yajima ◽

T. Ishizaki

Keyword(s):

Essential Hypertension ◽

Glucose Tolerance ◽

Reductase Inhibitor ◽

Coenzyme A ◽

Coenzyme A Reductase

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NK-104, A 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR, REDUCES OSTEOPONTIN EXPRESSION BY RAT AORTIC SMOOTH MUSCLE CELLS

3rd International Conference on Osteopontin and SIBLING (Small Integrin-Binding Ligand, N-linked Glycoprotein) Proteins, 2002 ◽

10.1100/tsw.2002.259 ◽

2002 ◽

Author(s):

Masaki Fujimoto ◽

Seijiro Mori ◽

Minoru Takemoto ◽

Sunao Asaumi ◽

Koutaro Yokote ◽

...

Keyword(s):

Smooth Muscle ◽

Smooth Muscle Cells ◽

Reductase Inhibitor ◽

Coenzyme A ◽

Muscle Cells ◽

Aortic Smooth Muscle Cells ◽

Aortic Smooth Muscle ◽

Osteopontin Expression ◽

Coenzyme A Reductase

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