Cross-Talk between Signal Transducer and Activator of Transcription (Stat5) and Thyroid Hormone Receptor-  1 (TR 1) Signaling Pathways

2000 ◽  
Vol 14 (9) ◽  
pp. 1411-1424 ◽  
Author(s):  
H. Favre-Young
Keyword(s):  
Thyroid Hormone ◽  
Signaling Pathways ◽  
Cross Talk ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Signal Transducer

3,5-Diiodothyronine-mediated transrepression of the thyroid hormone receptor beta gene in tilapia. Insights on cross-talk between the thyroid hormone and cortisol signaling pathways

2016 ◽  
Vol 425 ◽  
pp. 103-110 ◽  
Author(s):  
Gabriela Hernández-Puga ◽  
Pamela Navarrete-Ramírez ◽  
Arturo Mendoza ◽  
Aurora Olvera ◽  
Patricia Villalobos ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Signaling Pathways ◽  
Cross Talk ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Beta Gene ◽  
Receptor Beta

scholarly journals Oncogenic conversion of the thyroid hormone receptor by altered nuclear transport

2006 ◽  
Vol 4 (1) ◽  
pp. nrs.04008 ◽  
Author(s):  
Ghislain M.C. Bonamy ◽  
Lizabeth A. Allison
Keyword(s):  
Thyroid Hormone ◽  
Signaling Pathways ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Direct Interaction ◽  
Dominant Negative ◽  
Multiple Cell ◽  
Dominant Negative Activity ◽  
Dominant Negative Variant ◽  
Complex Signaling

Nuclear receptors (NRs) are transcription factors whose activity is modulated by ligand binding. These receptors are at the core of complex signaling pathways and act as integrators of many cellular signals. In the last decade our understanding of NRs has greatly evolved. In particular, regulation of NR subcellular dynamics has emerged as central to their activity. Research on the subcellular distribution of the thyroid hormone receptor (TR) has revealed new dimensions in the complexity of NR regulation, and points to the possibility that NR mislocalization plays a key role in oncogenesis. For many years, TR was thought to reside exclusively in the nucleus. It is now known that TR is a dynamic protein that shuttles between the nucleus and cytoplasm. TR is localized to the nucleus in a phosphorylated form, suggesting that compartment-specific phosphorylation mediates cross-talk between multiple cell signaling pathways. The oncoprotein v-ErbA, a viral-derived dominant negative variant of TR is actively exported to the cytoplasm by the CRM1 export receptor. Strikingly, the oncoprotein causes mislocalization of cellular TR and some of its coactivators by direct interaction. Here, we offer some perspectives on the role of subcellular trafficking in the oncogenic conversion of TR, and propose a new model for oncoprotein dominant negative activity.

Thyroid Hormone Receptor Is a Negative Regulator in p53-Mediated Signaling Pathways

1998 ◽  
Vol 17 (9) ◽  
pp. 743-750 ◽  
Author(s):  
GONZALO BARRERA-HERNANDEZ ◽  
QIMIN ZHAN ◽  
ROSEMARY WONG ◽  
SHEUE-YANN CHENG
Keyword(s):  
Thyroid Hormone ◽  
Signaling Pathways ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Negative Regulator

scholarly journals Inhibition of Peroxisome Proliferator Signaling Pathways by Thyroid Hormone Receptor

1997 ◽  
Vol 272 (12) ◽  
pp. 7752-7758 ◽  
Author(s):  
Takahide Miyamoto ◽  
Atsuko Kaneko ◽  
Tomoko Kakizawa ◽  
Hiroki Yajima ◽  
Keiju Kamijo ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Signaling Pathways ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Peroxisome Proliferator

scholarly journals Peroxisome Proliferator-activated Receptor Mediates Cross-talk with Thyroid Hormone Receptor by Competition for Retinoid X Receptor

1995 ◽  
Vol 270 (30) ◽  
pp. 18117-18122 ◽  
Author(s):  
Cristiana E. Juge-Aubry ◽  
Agnieszka Gorla-Bajszczak ◽  
Agns Pernin ◽  
Thomas Lemberger ◽  
Walter Wahli ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Cross Talk ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Retinoid X Receptor ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor

scholarly journals Tumor Suppressor p53 Is a Negative Regulator in Thyroid Hormone Receptor Signaling Pathways

1997 ◽  
Vol 272 (46) ◽  
pp. 28989-28993 ◽  
Author(s):  
Manoj Kumar Bhat ◽  
Chia-lin Yu ◽  
Nida Yap ◽  
Qimin Zhan ◽  
Yoshitaka Hayashi ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Tumor Suppressor ◽  
Signaling Pathways ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Negative Regulator ◽  
Receptor Signaling ◽  
Tumor Suppressor P53
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