scholarly journals Telephone-based cognitive behavioral therapy for depression in Parkinson disease

Neurology ◽  
2020 ◽  
Vol 94 (16) ◽  
pp. e1764-e1773 ◽  
Author(s):  
Roseanne D. Dobkin ◽  
Sarah L. Mann ◽  
Michael A. Gara ◽  
Alejandro Interian ◽  
Kailyn M. Rodriguez ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Parkinson Disease ◽  
Behavioral Treatment ◽  
Rating Scale ◽  
Controlled Trial ◽  
Cognitive Behavioral ◽  
Cognitive Behavioral Treatment ◽  
Treatment As Usual ◽  
Negative Thoughts

ObjectiveTo determine whether, for patients with depression and Parkinson disease (PD), telephone-based cognitive-behavioral treatment (T-CBT) alleviates depressive symptoms significantly more than treatment as usual (TAU), we conducted a randomized controlled trial to evaluate the efficacy of a 10-session T-CBT intervention for depression in PD, compared to TAU.MethodsSeventy-two people with PD (PWP) were randomized to T-CBT + TAU or TAU only. T-CBT tailored to PWPs’ unique needs was provided weekly for 3 months, then monthly during 6-month follow-up. CBT targeted negative thoughts (e.g., “I have no control”; “I am helpless”) and behaviors (e.g., social withdrawal, excessive worry). It also trained care partners to help PWP practice healthy habits. Blind raters assessed outcomes at baseline, midtreatment, treatment end, and 1 and 6 months post-treatment. Analyses were intent to treat.ResultsT-CBT outperformed TAU on all depression, anxiety, and quality of life measures. The primary outcome (Hamilton Depression Rating Scale score) improved significantly in T-CBT compared to TAU by treatment end. Mean improvement from baseline was 6.53 points for T-CBT and −0.27 points for TAU (p < 0.0001); gains persisted over 6-month follow-up (p < 0.0001). Improvements were moderated by a reduction in negative thoughts in the T-CBT group only, reflecting treatment target engagement.ConclusionsT-CBT may be an effective depression intervention that addresses a significant unmet PD treatment need and bypasses access barriers to multidisciplinary, evidence-based care.Clinicaltrials.gov identifierNCT02505737.Classification of evidenceThis study provides Class I evidence that for patients with depression and PD, T-CBT significantly alleviated depressive symptoms compared to usual care.

scholarly journals Efficacy of the unified protocol for transdiagnostic cognitive-behavioral treatment for depressive and anxiety disorders: a randomized controlled trial

2022 ◽  
pp. 1-12
Author(s):  
Masaya Ito ◽  
Masaru Horikoshi ◽  
Noriko Kato ◽  
Yuki Oe ◽  
Hiroko Fujisato ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Anxiety Disorders ◽  
Emotional Disorders ◽  
Behavioral Treatment ◽  
Depressive Disorders ◽  
Rating Scale ◽  
Controlled Trial ◽  
Principal Diagnosis ◽  
Treatment As Usual ◽  
Unified Protocol

Abstract Background The efficacy of the unified protocol of the transdiagnostic treatment for emotional disorders (UP) has been poorly studied in patients with depressive disorders. This study aimed to examine the efficacy of UP for improving depressive symptoms in patients with depressive and/or anxiety-related disorders. Methods This assessor-blinded, randomized, 20-week, parallel-group, superiority study compared the efficacy of the UP with treatment-as-usual (UP-TAU) v. wait-list with treatment-as-usual (WL-TAU). Patients diagnosed with depressive and/or anxiety disorders and with depressive symptoms participated. The primary outcome was depressive symptoms assessed by GRID-Hamilton depression rating scale (GRID-HAMD) at 21 weeks. The secondary outcomes included assessor-rated anxiety symptoms, severity and improvement of clinical global impression, responder and remission status, and loss of principal diagnosis. Results In total, 104 patients participated and were subjected to intention-to-treat analysis [mean age = 37.4, s.d. = 11.5, 63 female (61%), 54 (51.9%) with a principal diagnosis of depressive disorders]. The mean GRID-HAMD scores in the UP-TAU and WL-TAU groups were 16.15 (s.d. = 4.90) and 17.06 (s.d. = 6.46) at baseline and 12.14 (s.d. = 5.47) and 17.34 (s.d. = 5.78) at 21 weeks, with a significant adjusted mean change difference of −3.99 (95% CI −6.10 to −1.87). Patients in the UP-TAU group showed significant superiority in anxiety and clinical global impressions. The improvement in the UP-TAU group was maintained in all outcomes at 43 weeks. No serious adverse events were observed in the UP-TAU group. Conclusions The UP is an effective approach for patients with depressive and/or anxiety disorders.

Pattern of Changes during Treatment: A Comparison between a Positive Psychology Intervention and a Cognitive Behavioral Treatment for Clinical Depression

2017 ◽  
Vol 20 ◽  
Author(s):  
Irene Lopez-Gomez ◽  
Covadonga Chaves ◽  
Gonzalo Hervas ◽  
Carmelo Vazquez
Keyword(s):  
Depressive Symptoms ◽  
Positive Psychology ◽  
Repeated Measures ◽  
Behavioral Treatment ◽  
Mixed Model ◽  
Well Being ◽  
Clinical Depression ◽  
Cognitive Behavioral ◽  
Cognitive Behavioral Treatment ◽  
Gradual Improvement

AbstractResearch on psychotherapy has traditionally focused on analyzing changes between the beginning and the end of a treatment. Few studies have addressed the pattern of therapeutic change during treatment. The aim of this study was to examine the pattern of changes in clinical and well-being variables during a cognitive behavioral therapy (CBT) program compared with an integrative positive psychology interventions program for clinical depression IPPI-D. 128 women with a diagnosis of major depression or dysthymia were assigned to the CBT or PPI group. A measure of depressive symptoms (i.e., Beck Depression Inventory) and well-being (i.e., Pemberton Happiness Index) were administered four times: at the beginning and end of the treatment, as well as during treatment (at sessions 4 and 7). Through mixed-model repeated measures ANOVAs, both depressive symptoms (p < .001, partial η2 = .52) and well-being (p < .001, partial η2 = .29) showed a significant improvement through the four assessment times. No significant interactions between time and treatment modality were found (ps > .08). The percentage of improvement in depressive symptoms in the first treatment period was higher than in the later ones (ps < .005). On the contrary, well-being showed a more gradual improvement (p = .15). These results highlight the importance of assessing the pattern of changes in symptoms and well-being separately.

scholarly journals Cognitive-behavioral treatment of persistent functional somatic complaints and pediatric anxiety: an initial controlled trial

2011 ◽  
Vol 28 (7) ◽  
pp. 551-559 ◽  
Author(s):  
Carrie Masia Warner ◽  
Daniela Colognori ◽  
Rachel E. Kim ◽  
Laura C. Reigada ◽  
Rachel G. Klein ◽  
...  
Keyword(s):  
Behavioral Treatment ◽  
Controlled Trial ◽  
Somatic Complaints ◽  
Cognitive Behavioral ◽  
Cognitive Behavioral Treatment ◽  
Pediatric Anxiety
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