scholarly journals Opportunities for Understanding MS Mechanisms and Progression With MRI Using Large-Scale Data Sharing and Artificial Intelligence

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000012884
Author(s):  
Hugo Vrenken ◽  
Mark Jenkinson ◽  
Dzung Pham ◽  
Charles R.G. Guttmann ◽  
Deborah Pareto ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Image Analysis ◽  
Data Sharing ◽  
Large Scale ◽  
Personal Data ◽  
Human Observer ◽  
Imaging Data ◽  
Large Scale Data ◽  
Scale Data

Multiple sclerosis (MS) patients have heterogeneous clinical presentations, symptoms and progression over time, making MS difficult to assess and comprehend in vivo. The combination of large-scale data-sharing and artificial intelligence creates new opportunities for monitoring and understanding MS using magnetic resonance imaging (MRI).First, development of validated MS-specific image analysis methods can be boosted by verified reference, test and benchmark imaging data. Using detailed expert annotations, artificial intelligence algorithms can be trained on such MS-specific data. Second, understanding disease processes could be greatly advanced through shared data of large MS cohorts with clinical, demographic and treatment information. Relevant patterns in such data that may be imperceptible to a human observer could be detected through artificial intelligence techniques. This applies from image analysis (lesions, atrophy or functional network changes) to large multi-domain datasets (imaging, cognition, clinical disability, genetics, etc.).After reviewing data-sharing and artificial intelligence, this paper highlights three areas that offer strong opportunities for making advances in the next few years: crowdsourcing, personal data protection, and organized analysis challenges. Difficulties as well as specific recommendations to overcome them are discussed, in order to best leverage data sharing and artificial intelligence to improve image analysis, imaging and the understanding of MS.

scholarly journals The Development of the Older Persons and Informal Caregivers Survey Minimum DataSet (TOPICS-MDS): A Large-Scale Data Sharing Initiative

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e81673 ◽  
Author(s):  
Jennifer E. Lutomski ◽  
Maria A. E. Baars ◽  
Bianca W. M. Schalk ◽  
Han Boter ◽  
Bianca M. Buurman ◽  
...  
Keyword(s):  
Data Sharing ◽  
Older Persons ◽  
Large Scale ◽  
Informal Caregivers ◽  
Large Scale Data ◽  
Minimum Dataset ◽  
Scale Data

scholarly journals COINSTAC: Decentralizing the future of brain imaging analysis

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1512 ◽  
Author(s):  
Jing Ming ◽  
Eric Verner ◽  
Anand Sarwate ◽  
Ross Kelly ◽  
Cory Reed ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Data Sharing ◽  
Large Scale ◽  
Data Transfer ◽  
Imaging Data ◽  
Sensitive Data ◽  
Large Scale Data ◽  
Decentralized Algorithms ◽  
Neuroimaging Data ◽  
Brain Imaging Data

In the era of Big Data, sharing neuroimaging data across multiple sites has become increasingly important. However, researchers who want to engage in centralized, large-scale data sharing and analysis must often contend with problems such as high database cost, long data transfer time, extensive manual effort, and privacy issues for sensitive data. To remove these barriers to enable easier data sharing and analysis, we introduced a new, decentralized, privacy-enabled infrastructure model for brain imaging data called COINSTAC in 2016. We have continued development of COINSTAC since this model was first introduced. One of the challenges with such a model is adapting the required algorithms to function within a decentralized framework. In this paper, we report on how we are solving this problem, along with our progress on several fronts, including additional decentralized algorithms implementation, user interface enhancement, decentralized regression statistic calculation, and complete pipeline specifications.

scholarly journals Trust in Centralized Large-Scale Data Repository: A Qualitative Analysis

2019 ◽  
Vol 15 (4) ◽  
pp. 365-378 ◽  
Author(s):  
Reinder Broekstra ◽  
Judith Aris-Meijer ◽  
Els Maeckelberghe ◽  
Ronald Stolk ◽  
Sabine Otten
Keyword(s):  
Large Scale ◽  
Personal Data ◽  
Digital Data ◽  
Data Repository ◽  
Key Factors ◽  
Human Research ◽  
The Public ◽  
Large Scale Data ◽  
Depth Interviews ◽  
Scale Data

Exponential increases in digital data and calls for participation in human research raise questions about when and why individuals voluntarily provide personal data. We conducted 36 in-depth interviews with ex-participants, participants, and nonparticipants in a biobank to identify key factors influencing trust in centralized large-scale data repository for human research. Our findings indicated that trust depends strongly on whether such data repository benefits the public, the interests of data collectors, the characteristics of the collected data, and application of informed consent for retaining control over personal data. Concerns about the aims and range of data repository appeared to influence withdrawal of participation. Our findings underscore ethical and practical issues relating to data collection and consent procedures in human research.

Applying Rules as Policies for Large-Scale Data Sharing

2010 ◽  
Author(s):  
Arcot Rajasekar ◽  
Reagan Moore ◽  
Mike Wan ◽  
Wayne Schroeder ◽  
Adil Hasan
Keyword(s):  
Data Sharing ◽  
Large Scale ◽  
Large Scale Data ◽  
Scale Data

scholarly journals FlywheelTools: Data Curation and Manipulation on the Flywheel Platform

2021 ◽  
Vol 15 ◽  
Author(s):  
Tinashe M. Tapera ◽  
Matthew Cieslak ◽  
Max Bertolero ◽  
Azeez Adebimpe ◽  
Geoffrey K. Aguirre ◽  
...  
Keyword(s):  
Large Scale ◽  
Data Curation ◽  
Imaging Data ◽  
Large Scale Data ◽  
Neuroscience Research ◽  
Neuroimaging Data ◽  
Brain Imaging Data ◽  
Database Platform ◽  
The Brain ◽  
Scale Data

The recent and growing focus on reproducibility in neuroimaging studies has led many major academic centers to use cloud-based imaging databases for storing, analyzing, and sharing complex imaging data. Flywheel is one such database platform that offers easily accessible, large-scale data management, along with a framework for reproducible analyses through containerized pipelines. The Brain Imaging Data Structure (BIDS) is the de facto standard for neuroimaging data, but curating neuroimaging data into BIDS can be a challenging and time-consuming task. In particular, standard solutions for BIDS curation are limited on Flywheel. To address these challenges, we developed “FlywheelTools,” a software toolbox for reproducible data curation and manipulation on Flywheel. FlywheelTools includes two elements: fw-heudiconv, for heuristic-driven curation of data into BIDS, and flaudit, which audits and inventories projects on Flywheel. Together, these tools accelerate reproducible neuroscience research on the widely used Flywheel platform.

scholarly journals Big Data Analytics & Artificial Intelligence in Healthcare

2021 ◽  
Author(s):  
PRANJAL KUMAR ◽  
Siddhartha Chauhan
Keyword(s):  
Artificial Intelligence ◽  
Big Data ◽  
Large Scale ◽  
Health Sector ◽  
Big Data Analytics ◽  
Personal Data ◽  
Related Data ◽  
Large Scale Data ◽  
Ethical Policy ◽  
Health Related

Abstract Big data analysis and Artificial Intelligence have received significant attention recently in creating more opportunities in the health sector for aggregating or collecting large-scale data. Today, our genomes and microbiomes can be sequenced i.e., all information exchanged between physicians and patients in Electronic Health Records (EHR) can be collected and traced at least theoretically. Social media and mobile devices today obviously provide many health-related data regarding activity, diets, social contacts, and so on. However, it is increasingly difficult to use this information to answer health questions and, in particular, because the data comes from various domains and lives in different infrastructures and of course it also is very variable quality. The massive collection and aggregation of personal data come with a number of ethical policy, methodological, technological challenges. It should be acknowledged that large-scale clinical evidence remains to confirm the promise of Big Data and Artificial Intelligence (AI) in health care. This paper explores the complexities of big data & artificial intelligence in healthcare as well as the benefits and prospects.

scholarly journals Participants' Recall and Understanding of Genomic Research and Large-Scale Data Sharing

2013 ◽  
Vol 8 (4) ◽  
pp. 42-52 ◽  
Author(s):  
Jill Oliver Robinson ◽  
Melody J. Slashinski ◽  
Tao Wang ◽  
Susan G. Hilsenbeck ◽  
Amy L. McGuire
Keyword(s):  
Data Sharing ◽  
Large Scale ◽  
Genomic Research ◽  
Large Scale Data ◽  
Scale Data
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