Using motion perimetry to detect visual field defects in patients with idiopathic intracranial hypertension: A comparison with conventional automated perimetry

Neurology ◽  
1995 ◽  
Vol 45 (6) ◽  
pp. 1169-1175 ◽  
Author(s):  
M. Wall ◽  
E. B. Montgomery
Keyword(s):  
Visual Field ◽  
Intracranial Hypertension ◽  
Idiopathic Intracranial Hypertension ◽  
Visual Field Defects ◽  
Automated Perimetry ◽  
Field Defects

Neurofilament light chain as biomarker in idiopathic intracranial hypertension

Cephalalgia ◽  
2020 ◽  
Vol 40 (12) ◽  
pp. 1346-1354
Author(s):  
Dagmar Beier ◽  
Johanne Juhl Korsbæk ◽  
Jonna Skov Madsen ◽  
Dorte Aalund Olsen ◽  
Laleh Dehghani Molander ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Optic Nerve ◽  
Visual Field ◽  
Intracranial Hypertension ◽  
Idiopathic Intracranial Hypertension ◽  
Nerve Damage ◽  
Visual Field Defects ◽  
Neurofilament Light Chain ◽  
Optic Nerve Damage ◽  
Field Defects

Background Damage of the optic nerve is the major complication of idiopathic intracranial hypertension. A biomarker indicative for optic nerve damage would help identifying high-risk patients requiring surgical procedures. Here, we studied the potential of cerebrospinal fluid neurofilament to predict idiopathic intracranial hypertension-induced optic nerve damage. Methods In two centers, serum and cerebrospinal fluid of 61 patients with clinically suspected idiopathic intracranial hypertension were prospectively collected. Neurofilament concentrations were measured and related to ophthalmological assessment. Results The average cerebrospinal fluid neurofilament concentration in patients with moderate and severe papilledema was increased compared to patients with minor and no papilledema (1755 ± 3507 pg/ml vs. 244 ± 102 pg/ml; p < 0.001). Cerebrospinal fluid neurofilament concentrations correlated with the maximal lumbar puncture opening pressure (r = 0.67, p < 0.001). In patients fulfilling the Friedman criteria for idiopathic intracranial hypertension with or without papilledema (n = 35), development of bilateral visual field defects and bilateral atrophy of the optic nerve were associated with increased average age-adjusted cerebrospinal fluid neurofilament concentrations. At last follow-up (n = 30), 8/13 of patients with increased, but only 3/17 with normal, cerebrospinal fluid neurofilament had developed bilateral visual field defects and/or bilateral optic nerve atrophy resulting in a sensitivity of 72.7% and a specificity of 73.7% of cerebrospinal fluid neurofilament to detect permanent optic nerve damage. Conclusions Cerebrospinal fluid neurofilament is a putative biomarker for optical nerve damage in idiopathic intracranial hypertension.

scholarly journals Threshold Static Automated Perimetry of the Full Visual Field in Idiopathic Intracranial Hypertension

2019 ◽  
Vol 60 (6) ◽  
pp. 1898 ◽  
Author(s):  
Michael Wall ◽  
Ashwin Subramani ◽  
Luke X. Chong ◽  
Ramon Galindo ◽  
Andrew Turpin ◽  
...  
Keyword(s):  
Visual Field ◽  
Intracranial Hypertension ◽  
Idiopathic Intracranial Hypertension ◽  
Automated Perimetry

scholarly journals Visual Defects Associated with Vigabatrin: A Study of Epileptic Argentine Patients

2005 ◽  
Vol 32 (4) ◽  
pp. 459-464 ◽  
Author(s):  
María Cecilia Moreno ◽  
Brenda Giagante ◽  
Patricia Saidon ◽  
Silvia Kochen ◽  
Jorge Benozzi ◽  
...  
Keyword(s):  
Visual Field ◽  
Antiepileptic Drug ◽  
Screening Test ◽  
Screening Strategy ◽  
Visual Field Defects ◽  
Automated Perimetry ◽  
Field Screening ◽  
Full Field ◽  
Visual Defects ◽  
Field Defects

ABSTRACT:Objective:The aim of the present study was to assess visual alterations in a population of Argentine patients treated with the antiepileptic drug vigabatrin.Methods:Twenty patients receiving vigabatrin and 15 patients receiving carbamazepine were examined with automated perimetry using a Humphrey 120-point full screening strategy. In addition, scotopic flash electroretinograms were performed.Results:Of 20 patients treated with vigabatrin, two were unable to cooperate with testing. Of the remaining 18 patients, all but two showed at least one non-detected point inside the central 40° of the visual field of each eye. Of the 15 carbamazepine-treated patients, three were unable to perform the study. None of the remaining 12 patients showed visual field defects. Both a- and b-wave amplitudes of the scotopic electroretinogram were significantly reduced in 12 patients receiving vigabatrin.Conclusions:Visual field defects among patients on vigabatrin therapy may occur with a higher frequency than previously recognized. The Humphrey 120-points full field screening test and electroretinography are useful tools to assess the visual dysfunction associated with vigabatrin.

Classifying Patterns of Localized Glaucomatous Visual Field Defects on Automated Perimetry

2007 ◽  
Vol 16 (1) ◽  
pp. 146-152 ◽  
Author(s):  
Ramanjit Sihota ◽  
Viney Gupta ◽  
Deven Tuli ◽  
Ajay Sharma ◽  
Parul Sony ◽  
...  
Keyword(s):  
Visual Field ◽  
Visual Field Defects ◽  
Automated Perimetry ◽  
Field Defects

Retrogeniculate Visual Field Defects

Visual Fields ◽  
2010 ◽  
Author(s):  
Thomas R. Hedges III
Keyword(s):  
Visual Field ◽  
Vision Loss ◽  
Visual Fields ◽  
Field Testing ◽  
Visual Field Defects ◽  
Automated Perimetry ◽  
Loss Of Vision ◽  
Data Points ◽  
Field Defects ◽  
Macular Sparing

Automated perimetry has changed visual field testing considerably in recent years. What was considered an art has become an exercise in interpreting a set of data points obtained mechanically. Automated perimetry saves ophthalmologists time, which ideally should allow for more visual fields to be obtained on patients with unexplained vision loss. However, one must still keep in mind that automated perimetry still depends on the subjective responses from the patient. More important, automated perimetry has made interpretation of visual field defects, especially those due to occipital lesions, more difficult. For example, macular sparing may not be reflected, especially with programs limited to the central 24° or 30°. A 10° field may be required to show macular sparing. Also, sparing or involvement of the temporal crescent will not be shown with 24° or 30° visual fields. The limitation of most programs may lead to the appearance of incongruity when in fact the field is indeed congruous. Sometimes, a small homonymous hemianopic scotoma will be detected when one eye is tested but will be completely missed when the other eye is tested, giving the false impression that the visual loss is monocular. This is especially problematic if the patient also falsely interprets his or her homonymous loss of vision as monocular. Such individuals may complain of loss of vision in one eye when in fact it is one half of their visual field that is defective. The strategy of automated testing on either side the vertical and horizontal meridians may lead to the false impression that field defects respect the vertical or horizontal meridian when they do not. Automated perimetry should make it possible to test more patients with unexplained vision loss, but all automated visual fields must be interpreted with caution and, when necessary, substantiated with some other method, such as the tangent screen, which remains the most powerful method of detecting the size, shape, and density of visual field defects. Because most ophthalmologists no longer use tangent screen testing, at least an Amlser grid should be used to qualify the nature of a paracentral visual field defect.

scholarly journals Eye-tracking-based visual field analysis (EFA): a reliable and precise perimetric methodology for the assessment of visual field defects

2021 ◽  
Vol 6 (1) ◽  
pp. e000429
Author(s):  
Michael Christian Leitner ◽  
Florian Hutzler ◽  
Sarah Schuster ◽  
Lorenzo Vignali ◽  
Patrick Marvan ◽  
...  
Keyword(s):  
Eye Movements ◽  
Visual Field ◽  
Eye Tracking ◽  
Field Analysis ◽  
Visual Field Defects ◽  
Test Duration ◽  
Automated Perimetry ◽  
The Individual ◽  
The Right ◽  
Field Defects

ObjectiveSeveral studies report evidence for training-related neuroplasticity in the visual cortex, while other studies suggest that improvements simply reflect inadequate eye fixation control during perimetric prediagnostics and postdiagnostics.Methods and analysisTo improve diagnostics, a new eye-tracking-based methodology for visual field analysis (eye-tracking-based visual field analysis (EFA)) was developed. The EFA is based on static automated perimetry and additionally takes individual eye movements in real time into account and compensates for them. In the present study, an evaluation of the EFA with the help of blind spots of 58 healthy participants and the individual visual field defects of 23 clinical patients is provided. With the help of the EFA, optical coherence tomography, Goldmann perimetry and a Humphrey field analyser, these natural and acquired scotomas were diagnosed and the results were compared accordingly.ResultsThe EFA provides a SE of measurement of 0.38° for the right eye (OD) and 0.50° for the left eye (OS), leading to 0.44° of visual angle for both eyes (OU). Based on participants’ individual results, the EFA provides disattenuated correlation (validity) of 1.00 for both OD and OS. Results from patients suffering from cortical lesions and glaucoma further indicate that the EFA is capable of diagnosing acquired scotoma validly and is applicable for clinical use.ConclusionOutcomes indicate that the EFA is highly reliable and precise in diagnosing individual shape and location of scotoma and capable of recording changes of visual field defects (after intervention) with unprecedented precision. Test duration is comparable to established instruments and due to the high customisability of the EFA, assessment duration can be shortened by adapting the diagnostic procedure to the patients’ individual visual field characteristics. Therefore, the saccade-compensating methodology enables researchers and healthcare professionals to rule out eye movements as a source of inaccuracies in pre-, post-, and follow-up assessments.

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