Amyotrophic lateral sclerosis: Oxidative energy metabolism and calcium homeostasis in peripheral blood lymphocytes

Neurology ◽  
1996 ◽  
Vol 47 (4) ◽  
pp. 1060-1064 ◽  
Author(s):  
D. Curti ◽  
A. Malaspina ◽  
G. Facchetti ◽  
C. Camana ◽  
L. Mazzini ◽  
...  
2012 ◽  
Vol 17 (5) ◽  
pp. 22-25
Author(s):  
L. M Kurtasova ◽  
T. V. Lubnina

84 babies aged 1 to 3 years suffered from recurrent respiratory infections were studied. Cellular and humoral immunological parameters, phagocytic activity of neutrophils and activities of NAD- and NADP-dependent dehydrogenases in peripheral blood lymphocytes were estimated. Immunophenotypic changes found in blood lymphocytes included decreased IgA levels and a tendency of serum IgM to increase. An elevated level of circulating immune complexes was revealed in the blood serum. Decreased levels active neutrophils in the peripheral blood were detected. In the enzyme status of blood lymphocytes such changes as increased levels of synthetic processes and intense intracellular energy metabolism can be observed.


2021 ◽  
Vol 4 ◽  
pp. 8-15
Author(s):  
А. Kydyrmoldina ◽  
B. Zhetpisbayev ◽  
A. Utegenova ◽  
E. Omarkhanova ◽  
M. Malik ◽  
...  

The aim of the study was to study changes in immunological reactivity and biochemical processes in peripheral blood lymphocytes in Pakistani students under the action of muscle stress. To achieve this goal, the states of the immune, lipid peroxidation and antioxidant systems and energy metabolism were studied in 30 students from South Asia under the influence of muscle stress. The state of cellular, humoral and nonspecific phagocytic immunity was determined in all students before and 1, 2 and 3 days after the stress of muscle load. The research results show that the state of the immune system after muscle stress was characterized by phase changes in the parameters of cellular, humoral and nonspecific phagocytic immunity with a restoration or increase in indicators at the end of the observation. An increase in the activity of enzymes of energy metabolism in peripheral blood lymphocytes after stress of muscular load on days 2 and 3 after ensures the processes of successful adaptation. The state of lipid peroxidation and the antioxidant system in peripheral blood lymphocytes under muscle stress reflects the stress of the organism's adaptive reactions with the development of lipid hyperperoxidation under conditions of increased energy costs.


Sign in / Sign up

Export Citation Format

Share Document