The aim of the study was to study changes in immunological reactivity and biochemical processes in peripheral blood lymphocytes in Pakistani students under the action of muscle stress. To achieve this goal, the states of the immune, lipid peroxidation and antioxidant systems and energy metabolism were studied in 30 students from South Asia under the influence of muscle stress. The state of cellular, humoral and nonspecific phagocytic immunity was determined in all students before and 1, 2 and 3 days after the stress of muscle load. The research results show that the state of the immune system after muscle stress was characterized by phase changes in the parameters of cellular, humoral and nonspecific phagocytic immunity with a restoration or increase in indicators at the end of the observation. An increase in the activity of enzymes of energy metabolism in peripheral blood lymphocytes after stress of muscular load on days 2 and 3 after ensures the processes of successful adaptation. The state of lipid peroxidation and the antioxidant system in peripheral blood lymphocytes under muscle stress reflects the stress of the organism's adaptive reactions with the development of lipid hyperperoxidation under conditions of increased energy costs.